宫颈癌高危因素及检测的研究进展

宫颈癌是发生在全球妇女中仅次于乳腺癌的第2个常见的恶性肿瘤。从宫颈癌前病变(CIN)发展为宫颈癌是一个渐进的过程。在CIN的发展过程中如能早期发现,宫颈癌是可以完全治愈的。阻断病因和定期筛查是早期发现宫颈癌和切断其发展的重要手段,可最大限度地降低宫颈癌对妇女生命和健康的威胁。     

Molecular subtyping and virulence gene analysis of Listeria monocytogenes isolates from food

A total of 67 Listeria monocytogenes isolates from 698 raw meat samples were characterized for molecular serogroup identification and antimicrobial susceptibility. Approximately one third (32.8%) of the isolates belonged to molecular serogroup 1/2a, 3a, followed by 1/2c, 3c (26.9%), 1/2b, 3b, 7 (22.4%), 4b, 4d, 4e (16.4%) and 4a, 4c (1.5%). Most of the L. monocytogenes isolates were susceptible to 14 antimicrobials tested but several were resistant to tetracycline, ciprofloxacin and nitrofurantoin. An additional 30 L. monocytogenes isolates from chicken and produce in our collection were also included to determine the presence of significant virulence markers. All 97 isolates carried inlC and inlJ except for a lineage III isolate 110-1. Most Listeriolysin S (LLS)-carrying isolates (11/12) belonged to lineage I, whereas the remaining one isolate belonged to lineage III. Five 4b, 4d, 4e isolates including two from turkey and three from produce belonged to Epidemic Clone I (ECI). Four molecular serogroup associated mutation types that lead to premature stop codons (PMSCs) in inlA were identified. PFGE and inlA sequence analysis results were concordant, and different virulence potential within 1/2a, 3a and 4b, 4d, 4e isolates were observed. The study revealed that a subset of isolates from meat and produce belonged to ECI, harbored inlC, inlJ and LLS, and produced full length InlA, suggesting that they be capable of causing human illness.     

RFID为食品安全保驾护航

应用RFID技术能否加强对食品供应链进行监管,实现对食品生产销售各个环节的追踪,疫情发生后的感染途径追溯,进而杜绝疫情的传播并消除其他隐患,确保食品的安全等问题的探讨渐渐成为社会普遍关注的热点。     

肾综合征出血热灭活疫苗毒株L99株的全基因序列分析

目的 了解我国肾综合征出血热疫苗生产毒株Ｌ９９株的分子特征及抗原性的分子基础。方法 设计出不同的引物，用ＰＣＲ方法提取细胞总ＲＮＡ，逆转录扩增产物纯化后克隆Ｔ载体，纯化后测序，序列用ＤＮＡＳ ＴＡＲ软件拼接，并对其序列进行分析。结果Ｌ９９株全基因组由Ｌ片段６５３３个，Ｍ３６５２个，Ｓ１７６４个核苷酸组成， 分别编码２１５１、１１３３、４２９个氨基酸，Ｌ９９与同型病毒间同源率高达９５．５％－９９．４％。结论 为研究疫苗毒株的生物 学特性、致病机理等提供了分子基础。     

烟草马铃薯Y病毒病流行规律的初步研究

根据1996~2002年有关气象因素的数据,建立了气温、降水量与PVY病情指数的相关方程。选用几种模型对PVY的流行规律进行拟合检验,确定Gompertz模型为短期流行过程的最优拟合方程,并建立了流行速率与有翅蚜量关系的模型。根据田间病情调查的结果,初步得出模拟病害近距离传播的时空动态模型。     

SA_(14)-14-2株乙型脑炎活疫苗流行病学效果观察

本文报道了1～10岁儿童普种乙脑活苗后,乙脑发病率下降情况。结果表明,乙脑活苗接种能使乙脑发病率下降70％左右(P<0.01)。在普种乙脑活苗后的3年中。发生的1～10岁乙脑病例有95％以上未接种乙脑活苗,并出现了乙脑发病年龄上移的趋势(P<0.05),表明乙脑活苗具有较好的保护效果。     

Traffic-driven epidemic spreading and its control strategies

Many epidemics or viruses in real life spread by taking advantage of other dynamic processes, e.g., the computer virus propagates with the transmission of packets. In this paper, we survey the recent progress in the study of Traffic-Driven Epidemic Spreading (TDES) on complex networks. First, we introduce several typical TDES models. Then, we analyze the key factors which have significant impact on the epidemic threshold, such as the traffic congestion and routing protocols. Furthermore, we discuss the control of the TDES by focusing on the network structure optimization and the immunization strategies. Finally, we put some issues that need to be further explored in the future.     

某部5年法定传染病发病情况分析

了解某部传染病谱及传染病的发病特点、流行规律,预测流行趋势,为制定有效的预防策略和措施提供依据。利用该部所属单位的传染病上报资料信息,使用Excel进行统计分析。5年内该部报告传染病3917例(包括食物中毒31例)。其中,甲类传染病无报告;乙类传染病共报告3413例,占报告发病数的87.13%;丙类273例,占6.97%;其它非法定传染病200例;食物中毒31例。该部传染病疫情发生有明显的季节性,年初和年末发病数较少,8月份有1个发病高峰,7～9月份发病数最多,为1191例,占所有发病数的30.41%。血源及性传播传染病在以传播途径划分的各类传染病中居首位,高达35.69%;病毒性肝炎共报告发病1432例,居报告传染病第一位,占全部传染病报告发病数的36.56%。该部传染病疫情不容乐观,要重点加强对病毒性肝炎、肺结核和细茵性痢疾的监控力度,加强新兵检疫和平时的教育管理,并且针对不同传染病的发病特点和高发原因,采取预防接种、消毒、防护等综会措施。     

新型肺炎疫情防控背景下的“共创型”社区互助服务系统设计策略研究

面对新型肺炎来袭,社区作为社会构成最基本单元肩负着重要使命,通过洞察社区防疫需求,凝练和归纳出"共创型"的社区防疫互助服务系统设计策略--"医疗救助+实时信息+资源共享+空间管理",为我国在社会治理层面上进行疫情防控提供可借鉴和参考经验。     

Structure-Preserving Dynamics of Stochastic Epidemic Model with the Saturated Incidence Rate

The structure-preserving features of the nonlinear stochastic models are positivity, dynamical consistency and boundedness. These features have a significant role in different fields of computational biology and many more. Unfortunately, the existing stochastic approaches in literature do not restore aforesaid structure-preserving features, particularly for the stochastic models. Therefore, these gaps should be occupied up in literature, by constructing the structure-preserving features preserving numerical approach. This writing aims to describe the structure-preserving dynamics of the stochastic model. We have analysed the effect of reproduction number in stochastic modelling the same as described in the literature for deterministic modelling. The usual explicit stochastic numerical approaches are time-dependent. We have developed the implicitly driven explicit approach for the stochastic epidemic model. We have proved that the newly developed approach is preserving the structural, dynamical properties as positivity, boundedness and dynamical consistency. Finally, convergence analysis of a newly developed approach and graphically illustration is also presented.