On the synthesis and characterization of a new manganite type CMR material: La0.7Hg0.3MnO3

A new manganite type CMR material, La_0.7Hg_0.3MnO₃ has been successfully synthesized and has been found to exhibit magnetoresistance (≈9%) at low fields (≈1.5 kG). The synthesis has been carried out through a solid state reaction route consisting of the formation of La_0.7MnO₃ followed by diffusion of Hg leading to La_0.7Hg_0.3MnO₃. The as grown samples are polycrystalline and correspond to an orthorhombic unit cell with the lattice parameters; a=5.5183 Å, b=5.6383 Å and c=7.5368 Å. The typical grain size as revealed by scanning electron microscopy is in the range of 0.5–2 μm. The ρ–T behaviour shows a peak at T_IM=227 K. The ρ–T behaviour above this temperature corresponds to that of an insulator and below this to that of a metal. The ρ–T behaviour remains unaltered when a magnetic field (H_dc=1.5 kG) is applied. However, with this magnetic field a drop in the resistivity is observed up to 77 K. At room temperature the magnetoresistance ratio (MRR) is too small but it steadily increases as the temperature is decreased. Thus, MRRs at 227.13 and 77 K are 3.41 and 9.05%, respectively, in an applied field of H_dc=1.5 kG. At a given temperature the variation in MRR with field H_dc is rapid at lower field values (H_dc<1.2 kG) and scales linearly for higher field values (H_dc>1.2 kG). It may be mentioned that the present work on the synthesis and magnetoresistance behaviour of La_0.7Hg_0.3MnO₃, is the first of its type.     

Modeling guided wave propagation with application to the long-range defect detection in railroad tracks

The aim of this work is to demonstrate the use of a commercial finite element package, ABAQUS EXPLICIT, to model ultrasonic guided waves in structural components. The particular application of interest is modeling the interaction of a broadband vertical bending mode with transverse-type defects in railroad tracks. This topic is part of a broader project on high-speed defect detection in rails by long-range ultrasonic inspections. Reflection coefficient spectra in the 20–45 kHz range are obtained for four different sizes and three different orientations of transverse head flaws. A preliminary study of Lamb waves in a free plate helps drawing modeling guidelines for the rail.     

全封闭大功率永磁牵引电机的温度场数值计算

为研究全封闭大功率永磁牵引电机额定工况下的稳态温度场,以一台额定功率为815 kW的永磁同步牵引电机为研究对象,依据成型绕组槽部导热模型,建立了整机三维温度场共轭传热计算模型。考虑旋转磁化、冲压过程和磁密高阶谐波对定子铁耗的影响,以及水套-定子铁心间接触热阻抗对电机温升的影响,采用Fluent软件对电机额定工况下的稳态流场与温度场求解,使用电阻法和埋置检温计法（ETD）测得电机在额定工况下绕组的平均温升、铁心测点和绕组端部测点局部温升,绝对误差分别为-3.7 K、-0.3 K和7.6 K。进一步分析了电机水路和内风路流场分布特性、水套-定子铁心间接触间隙对绕组平均温升的影响以及槽内绕组附近的温升分布情况,最后提出了该类电机冷却系统设计优化方向。     

Insights into the Action Mechanism of the Antimicrobial Peptide Lasioglossin III

Lasioglossin III (LL-III) is a cationic antimicrobial peptide derived from the venom of the eusocial bee Lasioglossum laticeps. LL-III is extremely toxic to both Gram-positive and Gram-negative bacteria, and it exhibits antifungal as well as antitumor activity. Moreover, it shows low hemolytic activity, and it has almost no toxic effects on eukaryotic cells. However, the molecular basis of the LL-III mechanism of action is still unclear. In this study, we characterized by means of calorimetric (DSC) and spectroscopic (CD, fluorescence) techniques its interaction with liposomes composed of a mixture of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-rac-phosphoglycerol (POPG) lipids as a model of the negatively charged membrane of pathogens. For comparison, the interaction of LL-III with the uncharged POPC liposomes was also studied. Our data showed that LL-III preferentially interacted with anionic lipids in the POPC/POPG liposomes and induces the formation of lipid domains. Furthermore, the leakage experiments showed that the peptide could permeabilize the membrane. Interestingly, our DSC results showed that the peptide-membrane interaction occurs in a non-disruptive manner, indicating an intracellular targeting mode of action for this peptide. Consistent with this hypothesis, our gel-retardation assay experiments showed that LL-III could interact with plasmid DNA, suggesting a possible intracellular target.     

Quest for the Crypto-phosphoproteome

Protein phosphorylation is one of the most studied post-translational modifications (PTMs). Despite the remarkable advances in phosphoproteomics, a chemically less-stable subset of the phosphosites, which we call the crypto-phosphoproteome, has remained underexplored due to technological challenges. In this Viewpoint, we briefly summarize the current understanding of these elusive protein phosphorylations and identify the missing pieces for future studies.     

体积成形有限元模拟软件CASFORM的开发研究

简要介绍了作者自主开发的体积成形有限元模拟软件CASFORM及其关键技术，并给出了大量的实例分析。CASFORM主要由前处理模块，有限元分析模块，后处理模块，有限元网格生成模块和网格再划分及数据传递模块以及材料数据库和模拟数据库等构成，该软件能够分析各种体积成形工艺，包括锻造、挤压、拉拔等。能够预测缺陷的生成，验证和优化工艺/模具设计方案，该软件既能模拟等温成形过程，也可以模拟非等温成形过程，即可进行单工位成形分析，也可进行多工位成形分析。该软件界面友好，使用方便，可靠性和自动化程度高，是模具和工艺设计方案验证和优化的有力工具。     

渗碳材料涡流测试系统的研究

以通用有限元分析软件ANSYS作为二次开发平台，开发了面向渗碳材料的涡流测试系统。该系统将有限元前处理、涡流电磁场计算、渗碳层深度逆问题求解及计算结果的可视化处理结合起来，提供了良好的用户界面。     

Ф400mm自动轧管机有限元模拟及工艺优化

为提高包钢钢联股份有限公司Ф400mm自动轧管机轧制的钢管壁厚精度．进行了轧卡试验及有限元模拟分析，获得了钢管在孔型中的应变分布状况，经过优化孔型参数和改进轧辊孔型，使轧制的钢管横向和纵向壁厚偏差大大减小。     

CY4102BZQ柴油机机体模态分析

以东风朝阳柴油机厂最新开发的CY4102BZQ柴油机机体为研究对象，利用Pro／E三维软件和I-DEAS有限元软件建立了结构的实体模型和有限元模型，进行了机体的模态分析计算，获得了机体的基本振型和相关频率。应用模态试验验证了模型的精确程度，从而提出合理的改进方案。     

冷拔内螺纹管拉拔力的有限元计算方法

本文基于三维弹塑性大变形有限元分析理论,通过对内螺旋凸筋管冷拔成形过程进行有限元仿真,建立增量步与拉拔力的关系,提出了拉拔力的计算方法.经实验验证,理论计算值与实测值相吻合,可为拉拔模具和工艺参数的设计提供参考.