串联蓄电池均衡充电系统

用电感、二极管和开关器件构成串联蓄电池充电的均衡电路,使蓄电池在串联的情况下,实现均衡充电.分析了均衡器的工作原理,指出该均衡器具有动态分配过充电能的特点.利用蓄电池的充电电压和充电状态之间的关系,用蓄电池的状态估计法和倒推法,解决了均衡器中开关器件的PWM脉冲占空比的计算问题.整个串联蓄电池充电系统具有结构简单、灵活和可扩展的优点.     

Complex Elucidation of Cells-of-Origin in Pediatric Soft Tissue Sarcoma: From Concepts to Real Life,Hide-and-Seek through Epigenetic and Transcriptional Reprogramming

Soft tissue sarcoma (STS) comprise a large group of mesenchymal malignant tumors with heterogeneous cellular morphology, proliferative index, genetic lesions and, more importantly, clinical features. Full elucidation of this wide diversity remains a central question to improve their therapeutic management and the identity of cell(s)-of-origin from which these tumors arise is part of this enigma. Cellular reprogramming allows transitions of a mature cell between phenotypes, or identities, and represents one key driver of tumoral heterogeneity. Here, we discuss how cellular reprogramming mediated by driver genes in STS can profoundly reshape the molecular and morphological features of a transformed cell and lead to erroneous interpretation of its cell-of-origin. This review questions the fact that the epigenetic context in which a genetic alteration arises has to be taken into account as a key determinant of STS tumor initiation and progression. Retracing the cancer-initiating cell and its clonal evolution, notably via epigenetic approach, appears as a key lever for understanding the origin of these tumors and improving their clinical management.     

深厚表土层地区混凝土井壁变形监测及灰色模型预测

基于深厚表土层地区混凝土井壁破裂变形预测及井壁破裂预防性信息化施工的需要,介绍混凝土井壁变形自动监测的原理、方法及监测特点,基于实测监测信息,建立某井壁混凝土变形预测非等间隔灰色预测模型,实测与预测结果表明该模型可用于混凝土井壁变形超前预测.     

神经网络智能诊断技术在混凝土结构中的理论实现与展望

混凝土结构诊断技术是现代建筑工业中的一个重要课题。基于人工神经网络的智能诊断,其融合了计算机技术与神经网络技术,并结合了工程设备的特征,它具有非线性、快速、精确等优点,更接近工程实际;同时,具有美好的发展前景。     

Superior Cerebellar Atrophy: An Imaging Clue to Diagnose ITPR1-Related Disorders

The inositol 1,4,5-triphosphate receptor type 1 (ITPR1) gene encodes an InsP₃-gated calcium channel that modulates intracellular Ca²⁺ release and is particularly expressed in cerebellar Purkinje cells. Pathogenic variants in the ITPR1 gene are associated with different types of autosomal dominant spinocerebellar ataxia: SCA15 (adult onset), SCA29 (early-onset), and Gillespie syndrome. Cerebellar atrophy/hypoplasia is invariably detected, but a recognizable neuroradiological pattern has not been identified yet. With the aim of describing ITPR1-related neuroimaging findings, the brain MRI of 14 patients with ITPR1 variants (11 SCA29, 1 SCA15, and 2 Gillespie) were reviewed by expert neuroradiologists. To further evaluate the role of superior vermian and hemispheric cerebellar atrophy as a clue for the diagnosis of ITPR1-related conditions, the ITPR1 gene was sequenced in 5 patients with similar MRI pattern, detecting pathogenic variants in 4 of them. Considering the whole cohort, a distinctive neuroradiological pattern consisting in superior vermian and hemispheric cerebellar atrophy was identified in 83% patients with causative ITPR1 variants, suggesting this MRI finding could represent a hallmark for ITPR1-related disorders.     

5-Fluorouracil Treatment of CT26 Colon Cancer Is Compromised by Combined Therapy with IMMODIN

Due to the physiological complexity of the tumour, a single drug therapeutic strategy may not be sufficient for effective treatment. Emerging evidence suggests that combination strategies may be important to achieve more efficient tumour responses. Different immunomodulators are frequently tested to reverse the situation for the purpose of improving immune response and minimizing chemotherapy side effects. Immodin (IM) represents an attractive alternative to complement chemotherapy, which can be used to enhance the immune system after disturbances resulting from the side effects of chemotherapy. In the presented study, a model of CT26 tumor-bearing mice was used to investigate the effect of single IM or its combination with 5-fluorouracil (5-FU) on colon cancer cells. Our results highlight that the beneficial role of IM claimed in previous studies cannot be generalised to all chemotherapeutic drugs, as 5-FU toxicity was not increased. On the contrary, the chemotherapeutic anti-cancer efficacy of 5-FU was greatly compromised when combined with IM. Indeed, the combined treatment was significantly less effective regarding the tumour growth and animal survival, most probably due to the increased number of tumour-associated macrophages, and increased 5-FU cytotoxic effect related to kidneys and the liver.     

A Mouse-Based Method to Monitor Wheat Allergens in Novel Wheat Lines and Varieties Created by Crossbreeding: Proof-of-Concept Using Durum and A. tauschii Wheats

Wheat allergies are potentially life-threatening because of the high risk of anaphylaxis. Wheats belong to four genotypes represented in thousands of lines and varieties. Monitoring changes to wheat allergens is critical to prevent inadvertent ntroduction of hyper-allergenic varieties via breeding. However, validated methods for this purpose are unavailable at present. As a proof-of-concept study, we tested the hypothesis that salt-soluble wheat allergens in our mouse model will be identical to those reported for humans. Groups of Balb/cJ mice were rendered allergic to durum wheat salt-soluble protein extract (SSPE). Using blood from allergic mice, a mini hyper-IgE plasma bank was created and used in optimizing an IgE Western blotting (IEWB) to identify IgE binding allergens. The LC-MS/MS was used to sequence the allergenic bands. An ancient Aegilops tauschii wheat was grown in our greenhouse and extracted SSPE. Using the optimized IEWB method followed by sequencing, the cross-reacting allergens in A. tauschii wheat were identified. Database analysis showed all but 2 of the durum wheat allergens and all A. tauschii wheat allergens identified in this model had been reported as human allergens. Thus, this model may be used to identify and monitor potential changes to salt-soluble wheat allergens caused by breeding.     

浮选图像中泡沫边缘分割

矿物浮选过程中泡沫的表面特征是浮选性能的重要指标,它可以实时、直观地反映浮选效果的变化,准确分割泡沫的边缘信息是浮选过程中一项重要的任务。近年来,研究人员提出了各种浮选泡沫图像分割算法,但浮选泡沫图像中存在泡沫数量多、泡沫间粘连严重以及边缘不清晰等问题,现存的方法由于其特征提取能力有限,无法精确的分割泡沫边缘。据此,本文利用深度学习提出了一种基于多尺度融合的浮选泡沫图像边缘分割算法,该算法通过引入一种深度高分辨率的编码结构以及一种基于注意力的分层融合方法来增强模型的特征提取能力,从而提高对于浮选泡沫边缘的分割效果。具体而言,深度高分辨率的编码结构可以在不同分辨率层级上同时维护特征信息,使我们的网络模型可以有效地捕捉不同尺度的信息,在提高图像语义理解能力的同时能够保持更多的细节信息,提高处理高分辨率以及密集任务图像的能力。除此之外,本文设计了一种基于注意力的分层融合方法来充分融合深层和浅层的特征图,使融合得到的特征图趋向于更重要的特征信息,从而提高识别浮选泡沫的边界和精确定位浮选泡沫的能力。该算法在泡沫边界分割数据集上凭借58.25的泡沫IoU以及73.62的泡沫Fscore取得了最佳的性能,证明了我们提出的算法可以更加准确地分割浮选泡沫边缘。     

Engineering practice of reducing ground subsidence by grouting into overburden bed-separated and similar model experiment

The subsidence prediction theory under the condition of grouting into bedseparated was developed. Reducing ground subsidence by grouting was carried out on eight fully-mechanized top-coal caving faces, by using the continuous grouting in multiple-layer to obtain experiment results of reducing subsidence under fully mining. The similar material model that can be dismantled under the condition of constant temperature and constant humidity was developed. The model was used to simulate the evolution of overburden bed-separated under such constraints of temperature and humidity, at the same time, and to test the hardening process of similar materials.     

The creep experiment and theoretical model analysis of gas- containing coal

A creep experiment of preformed molding coal under different confining pressures were carried out using self-developed 3-triaxial creep loading device for gas-containing coal, which loaded by Shimadzu AGI-250 kN electrical servo-controlled stiffness testing machine. Based on the experimental results, the variation trend of axial deformation under different stress states was studied, and creep failure characteristics of gas-containing coal under different confining pressures were analyzed. The experimental results were identified with seven-component nonlinear viscoelasto-plastic creep model （Hohai model）, and the creep material parameters were obtained. The experimental result complies well with the theoretical value of this model. It indicates that creep constitutive relation of gas-containing coal can be expressed by nonlinear viscoelasto-plastic creep model correctly.