Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis

Background: The assessment of human epidermal growth factor receptor 2 (HER2) gene amplification is essential in order to identify those patients affected by advanced gastric cancer who may benefit from Trastuzumab targeted therapy. Materials and Methods: With the aim to investigate the concordance rate in HER2 status between primary gastric carcinoma (GC) and synchronous lymphnode metastases, we investigated HER2 status in a cohort of 108 surgical formalin-fixed paraffin-embedded specimens of GC and matched synchronous metastatic lymph nodes collected from three different units of Anatomic Pathology in southern of Italy. Fleiss-Cohen weighted k statistics were used to assess the concordance rate of HER2 status. Results: HER2 amplification was observed in 17% of primary GCs and the overall concordance rate with corresponding nodal metastases was 90.74%. Changes in HER2 status between primary GC and matched synchronous metastases were evidenced in 10 (9.26%) cases. Of these, 6 cases were HER2 amplified in the primary GC and not amplified in the metastases, while 4 were HER2 not amplified in the primary tumour and amplified in the lymph node metastases. Conclusions: Although at present the simultaneous determination of HER2 in advanced gastric cancer and corresponding metastatic lymph nodes is not mandatory, the possibility that the synchronous metastases of GC have a different HER2 status from that of the primary tumour is of remarkable significance; Indeed this may have influence on the therapeutic management and prognosis of the patients.     

江苏油田H区固井质量影响因素分析及对策

为了解决江苏油田H区固井质量优质率偏低的问题,通过统计2013年上半年35口井固井质量、固井前钻井液性能、前置液性能、水泥浆性能以及其他影响因数,分析各单因素对水泥浆封固质量的影响,得到了影响固井质量的主要因素和优化值。但无法判断影响因数影响力大小,通过引入灰色系统理论,编写关联度计算程序,得到各影响因素对水泥浆封固质量的关联度。现场应用表明,根据影响因数关联度排序,控制关键影响因数,可有效提高固井质量。     

多阶邻接分布熵下的复杂网络节点相似性分析方法

为弥补宏观网络结构熵描述整体结构信息却忽略局部,而微观熵描述节点信息又较浅层单一的不足,提出一种节点多阶邻接分布熵,以度量节点多阶邻居的分布特征信息,便于在自定义阶数尺度上分析复杂网络结构.该熵随多阶邻居阶数的增长而增大,并在节点的离心率处收敛.在给定的尺度下,节点各阶邻居分布越均匀则多阶邻接熵越大.基于多阶邻接分布相...     

传感器网络中基于路由关键点的结点调度机制

无线传感器网络是由大量低能量、短寿命、不可靠的传感器结点组成的,延长网络寿命是一个主要的目标。良好的结点调度算法可以在保证网络性能的前提下,延长系统的寿命。据此提出了一种结点调度算法,通过关掉一些冗余的结点,降低整个系统的能量消耗,由此增加系统的寿命。该算法既保证了网络区域的覆盖范围,又维持了一些路径上的关键点,以便进行路由的时候不会中断。     

The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease

Although the number of therapeutic options for the treatment of inflammatory bowel disease (IBD) has increased in recent years, patients suffer from decreased quality of life due to non-response or loss of response to the currently available treatments. An increased understanding of the disease’s etiology could provide novel insights for treatment strategies in IBD. Lymphatic system components are generally linked to immune responses and presumably related to inflammatory diseases pathophysiology. This review aims to summarize findings on immune-mediated mechanisms in lymphoid tissues linked with IBD pathogenesis and (potential) novel treatments. Enhanced innate and adaptive immune responses were observed in mesenteric lymph nodes (MLNs) and other lymphoid structures, such as Peyer’s patches, in patients with IBD and in animal models. Furthermore, the phenomenon of lymphatic obstruction in the form of granulomas in MLNs and lymphatic vessels correlates with disease activity. There is also evidence that abnormalities in the lymphatic stromal components and lymph node microbiome are common in IBD and could be exploited therapeutically. Finally, novel agents targeting lymphocyte trafficking have been added to the treatment armamentarium in the field of IBD. Overall, gut-associated lymphoid tissue plays a key role in IBD immunopathogenesis, which could offer novel therapeutic targets.     

有机气体污染物对室内空气质量的影响初探

室内空气的品质已经越来越受到人们的关注,室内环境的污染物主要是是来源于建筑装饰材料,空肯,服装等生活用品与生活消费品,以及炊事,取暖,致冷空调和吸烟等产生的各种无机化合物和有机化合物,特别是甲醛、苯并[α]芘等严重影响人体健康。在分析了各种室内环境条件对室内空气品质的影响,提出了通过选用环保材料、“烘烤”加速污染物散发和通风换气、进行空气净化等措施来降低污染物浓度,提高室内空气质量。     

贪婪寻优算法在中继节点布局中的应用

针对目前中继节点布局算法所忽视的布局完成后网络整体能耗的问题,提出了基于最小通信网络距离因子的布局算法评价新标准,同时将中继节点布局禁区、通信路径不可逆等约束条件.解决方法上,采用了基于贪婪寻优算法的中继节点布局算法,实现了无线传感器网络中继节点的多约束容错性布局.仿真实验表明,提出的基于贪婪寻优算法的中继节点布局算法与常规中继节点布局算法相比,在降低通信网络整体能耗以及保证能耗均衡性方面具有明显的优势.     

门式刚架中半刚性节点的性能探讨

对半刚接门式刚架采用有限单元法进行了分析,研究过程中考虑了端板连接节点的半刚性以及构件的几何非线性,探讨了半刚性节点和刚性节点对门式刚架内力和位移的影响。     

门式刚架中半刚性节点的性能探讨

本文对半刚接门式刚架采用有限单元法进行了分析,研究过程考虑了端板连接节点的半刚性以构件的几何非线性,探讨了半刚性节点和刚性节点对门式刚架内力和位移的影响。     

图根导线结点网平差软件设计及实现

随着GPS-RTK测量技术的普及,针对“RTK＋全站仪”的图根控制网测量模式测设的导线控制网灵活多变。采用“结点法分别平差”数学模型,基于VisualStudio2005平台的VisualC＋＋语言进行软件编码,借助MicrosoftOfficeword2003的OLE组件实现资料输出形成word文档,形成了图根结点导线网平差软件,通过工程实例验证了程序算法的可靠性和可行性。