钢丝绳旋转性能测定及研究

钢丝绳承受载荷时,绝大多数结构的钢丝绳会绕其自身轴线旋转,旋转是钢丝绳难以克服的特性。介绍ISO 21669:2005给出的吊钩提升重物测定装置存在的缺点。设计了利用材料试验机测定钢丝绳旋转性能的新型测定装置,并选取典型结构的钢丝绳进行长度为直径100和150倍的旋转度试验,经过换算,得出长度为直径1 000倍的钢丝绳旋转的圈数偏差在0~1.7圈,证实了钢丝绳的旋转特性和抗旋转钢丝绳的优越性。新型测定装置优点:加载方便、安全;旋转角度测量精度高,可测定钢丝绳扭矩;测试范围广。     

全球造纸工业发展报告(2005)(续二)

目前，全球造纸行业集中度整体上并不是很高，仍处于一个竞争程受较高的垄断竞争型市场结构；但是北美和欧洲已经处于寡头垄断的市场结构；亚洲基本处于垄断竞争的市场结构；中国的市场集中度仍然相当低，但是处于快速提高的趋势。     

ISO 22000:2005在调配型酸性双蛋白饮料生产企业的应用

介绍了ISO 22000:2005在调配型酸性双蛋白饮料生产企业的应用,分析了调配型酸性双蛋白饮料生产过程的主要食品安全危害,确定了关键控制点,并制定了HACCP计划.     

Microbiological contamination of pig and cattle carcasses in different small-scale Swiss abattoirs

A total of 750 pig carcasses and 535 cattle carcasses from 17 small-scale abattoirs were sampled by excision at four sites (pig: neck, belly, back, ham; cattle: neck, brisket, flank, rump). Samples were examined for total viable counts (TVC) and Enterobacteriaceae. Mean TVCs ranged from 2.4 to 4.2 log(10)CFUcm(-2) on pig carcasses and from 2.7 to 3.8 log(10)CFUcm(-2) on cattle carcasses. With regard to EU Regulation (EC) No 2073/2005, TVCs were mainly considered satisfactory (pig: 81.3%; cattle: 71.4%). Amongst sites, the back (pigs) and neck (cattle) tended to yield higher TVCs. Enterobacteriaceae were detected in low counts on 23.9% of pig carcasses and 21.7% of cattle carcasses. Amongst abattoirs, Enterobacteriaceae prevalence on pig and cattle carcasses ranged from 2.0% to 56.0% and from 0.0% to 55.0%, respectively. Consequently, criteria of the EU Regulation proved to be a suitable tool for the appraisal of microbiological results (TVCs) from pig and cattle carcasses from small-scale abattoirs. Because the occurrence of Enterobacteriaceae on carcasses was too infrequent to ensure log normality, frequencies should be compared for these organisms.     

低剂量MSCT扫描在IV P输尿管显影不良中的临床应用

目的:探讨IVP输尿管显影不良后进行低剂量MSCT扫描的应用价值。方法:IVP输尿管显影不良后,立即或择期进行低剂量MSCT扫描。根据患者的体质情况(如腰围、体重),制定了三组低剂量MSCT扫描参数,不同体质的患者用相应不同扫描参数进行低剂量MSCT扫描,体质瘦小者用低KV、低MA进行低剂量MSCT扫描。统计42例用低剂量MSCT扫描的患者资料,总结其低剂量扫描后减少X线辐射剂量;又统计低剂量MSCT扫描后对输尿管、肾脏疾病的诊断价值。结果:综合分析IVP与低剂量扫描MSCT图像,结果显示为结石是输尿管和/或肾脏结石的首发原因,占64.3%。CT可以发现IVP不能显示的小结石。输尿管显影不良的原因中,输尿管、肾脏先天性疾病所占比率为29.4%。低剂量MSCT扫描可以解决IVP输尿管显影不良的原因。另外低剂量MSCT扫描时,MAS总量一般在1200³000 MAS,平均减少2100 MAS;CTDI值平均减少59.7%,相当于患者减少210次胸部DR片检查的辐射剂量。结论:IVP输尿管显影不良时,通过低剂量MSCT扫描,减少患者X线辐射剂量,解决了IVP输尿管显影不良的原因,为临床提供正确诊断。     

无人驾驶汽车行驶引导交互手势设计研究

目的 旨在构建符合用户认知的交互手势设计方法,提升非方向盘操控情境下的无人驾驶汽车行驶引导的用户体验。 方法 首先采用用户参与式设计的方法,提取出无人驾驶场景下车内与车外的行驶引导交互手势集合;其次,采用一致率比较方法确保手势交互系统的一致性,并在此基础上构建一套适用于车内外行驶引导的交互手势集合;最后,通过卡片分类法和模拟测试对构建的手势集进行可用性评估。结果 卡片分类法和模拟测试均显示采用了用户参与式设计和一致性计算相结合的设计方法所建立的无人驾驶汽车内外行驶引导交互手势集合达到了较好的用户体验预期,同时也验证了在车内外采用统一的行驶引导交互手势的可行性。结论 验证了手势交互在车内外对无人驾驶汽车行驶进行引导可以达到较好的用户体验,为无人驾驶汽车的用户体验研究提供了新的方向。     

Design,Synthesis, and Evaluation of WC5 Analogues as Inhibitors of Human Cytomegalovirus Immediate‐Early 2 Protein,a Promising Target for Anti‐HCMV Treatment

Although human cytomegalovirus (HCMV) infection is mostly asymptomatic for immunocompetent individuals, it remains a serious threat for those who are immunocompromised, in whom it is associated with various clinical manifestations. The therapeutic utility of the few available anti‐HCMV drugs is limited by several drawbacks, including cross‐resistance due to their common mechanism of action, i.e., inhibition of viral DNA polymerase. Therefore, compounds that target other essential viral events could overcome this problem. One example of this is the 6‐aminoquinolone WC5 , which acts by directly blocking the transactivation of essential viral Early genes by the Immediate‐Early 2 (IE2) protein. In this study, the quinolone scaffold of the lead compound WC5 was investigated in depth, defining more suitable substituents for each of the scaffold positions explored and identifying novel, potent and nontoxic compounds. Some compounds showed potent anti‐HCMV activity by interfering with IE2‐dependent viral E gene expression. Among them, naphthyridone 1 was also endowed with potent anti‐HIV activity in latently infected cells. Their antiviral profile along with their innovative mechanism of action make these anti‐HCMV quinolones a very promising class of compounds to be exploited for more effective antiviral therapeutic treatment.     

Inhibition of Human α‐Methylacyl CoA Racemase (AMACR): a Target for Prostate Cancer

The enzyme α‐methylacyl CoA racemase (AMACR) is involved in the metabolism of branched‐chain fatty acids and has been identified as a promising therapeutic target for prostate cancer. By using the recently available human AMACR from HEK293 kidney cell cultures, we tested a series of new rationally designed inhibitors to determine the structural requirements in the acyl component. An N‐methylthiocarbamate (K_i=98 nM ), designed to mimic the proposed enzyme‐bound enolate, was found to be the most potent AMACR inhibitor reported to date.