Effects of ready to drink teas on AhR- and PXR-mediated expression of cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and primary human hepatocytes

A variety of xenobiotics are taken in the diet and they can interfere with regulatory pathways of drug metabolizing enzymes in humans. This can result in food-drug interactions, which is undesirable clinical situation where drug pharmacokinetics are influenced by dietary compounds. Xenobiotics-mediated food-drug interactions include the induction of drug metabolizing cytochromes P450. The expression of the most important inducible cytochromes CYP1A and CYP3A4 are regulated by xenoreceptors PXR and AhR.We examined extracts from 17 different flavoured ready to drink teas (RDTs) for their capabilities to activate PXR and AhR receptors and to induce CYP3A4 and CYP1A genes. Primary cultures of human hepatocytes and cancer cell lines HepG2 and LS174T were used as in vitro models. Gene reporter assays, RT-PCR and Western blots were performed.We identified three RDTs that induced CYP3A4 mRNA and protein, implying a potential for food-drug interactions. Several RDTs slightly elevated CYP1A1 expression or activated AhR.     

LS-DYNA在工程抗震中的应用

介绍了LS—DYNA软件以及在工程抗震中应用的特点，列举了该软件在高层建筑、地下工程、边坡、土石坝工程抗震分析中的应用以及对人工震源模拟的适用性。     

基于鲁棒最小二乘支持向量机的气动参数拟合

最小二乘支持向量机（LS－SVM）比标准支持向量机具有更高的计算效率,但是却散失了标准支持向量机的稀疏特性,而且当考虑异常值或者误差变量的高斯假设不成立时,会导致不稳健的估计结果。为了克服这两个缺点,在飞行器的气动参数拟合计算中引入了一种鲁棒最小二乘支持向量机（RLS－SVM）,该方法通过加权的支持向量机来获得鲁棒估计,并通过对支持值谱进行剪枝最终得到稀疏解。仿真结果表明：RLS－SVM方法简单,学习速度快,拟合精度高,鲁棒性强,是一种在飞行器轨迹计算中值得推广和采用的方法。     

In Vivo Evaluation of Sgc8-c Aptamer as a Molecular Imaging Probe for Colon Cancer in a Mouse Xenograft Model

Recent biotechnological applications in the field of clinical oncology led to the identification of new biomarkers as molecular targets of cancer, and to broad developments in the field of personalized medicine. Aptamers are oligonucleotides (ssDNA or RNA) that are selected to specifically recognize a molecular target with high affinity and specificity. Based on this, new horizons for their use as molecular imaging probes are being explored. The objective of this work was to evaluate the Sgc8-c aptamer conjugated with Alexa Fluor 647 fluorophore as an imaging probe in a colon tumor xenograft mouse model, with potential application in molecular imaging. In this study, the LS174T cell line was used to induce colorectal adenocarcinoma in nude mice. After confirmation of PTK7 overexpression by immunohistochemistry, in vivo studies were performed. Pharmacokinetic, in vivo and ex vivo biodistribution imaging, and a competition assay were evaluated by fluorescence imaging. In vivo visualization of the probe in the tumors was assessed two hours after aptamer probe administration, exhibiting excellent tumor-to-background ratios in biodistribution studies and high specificity in the competition test. Our results demonstrated the functionality of Scg8-c as an imaging probe for colon cancer, with potential clinical applications.     

两指标AR过程LS估计的渐近正态性

在两指标AR过程的参数估计问题中,LS估计是最基本的参数估计方法之一。本文给出了两指标AR过程LS估计的渐近正态性.     

Improved taylor-series location algorithm for cooperation networks

This article presents an iterative algorithm for estimating the location of the destination mobile station (DS) when some extra mobile stations around the DS are involved in and assist the base stations to complete the localization process. The proposed method is based on the taylor-series (TS) method and jointly estimates both the DS and the extra mobile stations, named reference mobile station (RS) in this article, positions simultaneously. Moreover, the time-differential-of-arrival (TDOA) measurements between DS and pairs of RSs are obtained by ultra-wide-band (UWB) signal, which is adept in accurate ranging application. According to the theoretic analysis, the Cramér-Rao lower bound (CRLB) of the modified TS algorithm reduces significantly. The actual performance, under a given simulation scenario, is enhanced by 25% at best.     

Performance Analysis of UWB Channels for Wireless Personal Area Networks

Ultra-wide band (UWB) communication is one of the most promising technology for high data rate networks over short-range communication. The ultra-wide bandwidth offers pulses with very short duration that provides frequency diversity and multipath resolution. Ultra-wide band (UWB) channels raise new effects in the receiver, the amplitude fading statistics being different compared to the conventional narrow band wireless channels. This review paper focuses on modeling of ultra-wide band channels, especially for simulation of personal area networks and also discusses the benefits, application potential and technical challenges in wideband communication. The concept of Orthogonal Frequency Division Multiplexing (OFDM) has recently been applied in wireless communication systems due to its high data rate transmission capability with high bandwidth efficiency and its robustness to multi-path delay. UWB OFDM communication was proposed for physical layer in the IEEE 802.15.3a standard which covers wideband communication in wireless personal area networks. Since the channel model for multicarrier UWB communication is different from that of plain ultra-wide band channel, a novel modification method in UWB channel model is proposed with specific center frequency and multipath resolution. Moreover, dynamic channel estimation is necessary before demodulation of UWB OFDM signals since the radio channel is time varying and frequency selective for wideband systems. The performance of the proposed method is statistically analyzed using LS and MMSE based channel estimation methods.     

OFDM系统基于导频的信道估计算法分析

正交频分复用（OFDM）技术是新一代宽带无线通信最具竞争力的备选方案之一,在众多的高速数据传输领域得到广泛地应用。文章对几种典型信道估计算法的复杂度和估计性能进行了理论分析,并分析了导频位置及疏密对估计性能的影响。仿真结果有力地验证了文章的理论分析。文章的分析可以为OFDM系统信道估计算法的选择及导频的放置及其疏密度的设计提供一定的参考。     

超声检测中单通道变多通道信号切换控制

针对小模数齿轮缺陷自动检测的特点,采用逻辑门、总线缓冲器74LS126和固态继电器组合实现单通道变多通道的切换控制,以达到单通道探伤仪当多通道使用的目的。     

一种MIMO-OFDM系统的信道估计算法

导频辅助的最小平方（LS）算法是MIMO—OFDM系统中常用的信道估计方法,特点是易于实现,但精度不高。基于最小均方误差（MMSE）的信道估计算法性能较好,但复杂度高,难以实现。提出了一种基于离散傅里叶变换（DFT）的信道估计算法,首先将LS信道估计循环前缀长度以外的时域响应值置零,然后选择重要路径,再通过计算参考导频的相位偏移量来进行补偿,最终实现信道的估计。算法能够满足一定的估计精度,且便于实现。仿真数据证明了算法的有效性。