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Two kinds of rhenium labeled radiopharmaceuticals for therapy of the human brain glioma were prepared.Anti-human brain glioma monoclonal antibody (McAb-SZ39) was directly labeled with 186 ReO4^-.When ascorbic acid was used as reduction agent of antibody and the reduction of 186 ReO4^- was finished in sodium gluconate solution(pH=2.54),the labeling efficiency was 96.2%,After purification,the labeled products were tested in respect of immunoreactivity,in vitro stability as well as inhibitory efficiency against human glioma transplanted in nude mice,188ReO4^- labeled colloid was synthesized by using a two-step method.The size of radiocolloid particles was around 2-5μm,and the radiochemical yield was over 95%,Nude mice Experiments demonstrated that the inhibitory efficiency against human brain glioma of 188Re-collied and ^188 Re-McAb-SZ39 was 90% and 65% ,respectively. 相似文献
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马志欣 《数字社区&智能家居》2007,3(14):386-388
随着我国互联网技术及其应用的发展,三网融合已成为必然趋势,也是下一代网络NGN的主要焦点之一.传统的电信网、计算机网(主要指因特网)和有线电视网正通过各种方式趋向于相互渗透和融合,本文阐述了基于IP技术的三网融合策略的原因、IP技术目前所存在的问题以及用MPLS解决主要问题的相关的实现思想. 相似文献
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服务质量(Qos)和流量工程(TE)是在当今网络中提供实时应用业务的两种重要技术。多协议标记交换(MPLS)在IP网Qos提供和TE功能实现中起了关键作用。首先介绍了区分服务感知的流量工程(DS-TE),然后提出了一种基于DS-TE的网络流量分配新方法。给出了相关的数学模型,并进行了相应的仿真,仿真结果表明使用该方法实施DS-TE时,在满足不同业务的QoS同时能较好地均衡网络负荷。 相似文献
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Weighted voting is the commonly used strategy for combining predictions in pairwise classification. Even though it shows good classification performance in practice, it is often criticized for lacking a sound theoretical justification. In this paper, we study the problem of combining predictions within a formal framework of label ranking and, under some model assumptions, derive a generalized voting strategy in which predictions are properly adapted according to the strengths of the corresponding base classifiers. We call this strategy adaptive voting and show that it is optimal in the sense of yielding a MAP prediction of the class label of a test instance. Moreover, we offer a theoretical justification for weighted voting by showing that it yields a good approximation of the optimal adaptive voting prediction. This result is further corroborated by empirical evidence from experiments with real and synthetic data sets showing that, even though adaptive voting is sometimes able to achieve consistent improvements, weighted voting is in general quite competitive, all the more in cases where the aforementioned model assumptions underlying adaptive voting are not met. In this sense, weighted voting appears to be a more robust aggregation strategy. 相似文献
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Juankun Zhang Min Li Peidong XuShuhai Jiang Yuliang LiuYi Chen Lijuan LiuZuoliang Sha 《Materials Science and Engineering: B》2013,178(18):1191-1194
A novel biosensor (the synthetic receptor sensor) employing the molecular imprinted technology for the digoxin analysis is investigated. The molecularly imprinted polymer (MIP) modified electrode can specifically bind to the analyte in the sample without sample pretreatment. The digoxin analyzed by the MIP sensor was carried out in 1 mM K3Fe(CN)6 solution with the cyclic voltammetry. In the system, the K3Fe(CN)63−/Fe2(CN)64− redox couple was taking place. When the solution contains the digoxin, the MIP on the electrode will bind the digoxin. Further the redox system is interrupted and the peak current is decreased according to the digoxin concentration increasing. Digoxin is a glycosylated steroid-like drug. It is important for the heart disease treatment. However, since the digoxin toxic level is low, the drug remains in the blood sample must be monitored frequently. The device possesses many advantages, such as high specific recognition properties, good chemical and mechanical stability, simplicity and low cost of preparation, sensitive and label free determination. The reproducibility is good (CV < 5). The linear relationship between the digoxin concentration and the current is 1.28–128 nM, and a detection limit of 1.28 nM is achieved. The detection time is less than 5 min. 相似文献
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Irreducible decomposition of monomial ideals has an increasing number of applications from biology to pure math. This paper presents the Slice Algorithm for computing irreducible decompositions, Alexander duals and socles of monomial ideals. The paper includes experiments showing good performance in practice. 相似文献