Rhenium labeled McAb—SZ39 and colloid

Two kinds of rhenium labeled radiopharmaceuticals for therapy of the human brain glioma were prepared.Anti-human brain glioma monoclonal antibody (McAb-SZ39) was directly labeled with 186 ReO4^-.When ascorbic acid was used as reduction agent of antibody and the reduction of 186 ReO4^- was finished in sodium gluconate solution(pH=2.54),the labeling efficiency was 96.2%,After purification,the labeled products were tested in respect of immunoreactivity,in vitro stability as well as inhibitory efficiency against human glioma transplanted in nude mice,188ReO4^- labeled colloid was synthesized by using a two-step method.The size of radiocolloid particles was around 2-5μm,and the radiochemical yield was over 95%,Nude mice Experiments demonstrated that the inhibitory efficiency against human brain glioma of 188Re-collied and ^188 Re-McAb-SZ39 was 90% and 65% ,respectively.     

关于三网融合关键技术——MPLS的探讨

随着我国互联网技术及其应用的发展,三网融合已成为必然趋势,也是下一代网络NGN的主要焦点之一.传统的电信网、计算机网(主要指因特网)和有线电视网正通过各种方式趋向于相互渗透和融合,本文阐述了基于IP技术的三网融合策略的原因、IP技术目前所存在的问题以及用MPLS解决主要问题的相关的实现思想.     

基于GMPLS的光突发交换体系及其关键技术

文章给出了基于通用多协议标签交换(GMPLS)的光突发交换(OBS)对等体系(GLOBS)的功能结构和分层视图.在此范畴内,针对标签空间减小和流量工程两方面,结合国内外最新的研究动态,比较了各种已有技术的优缺点,并提出了适合于GLOBS体系的可能的解决方案以及今后工作的重要技术问题.     

HMIPv6 over MPLS——一种适用于3G接入网的移动性管理方案

随着3G网络的快速发展，人们对它在移动性管理和网络服务质量方面的期望值也随之提高。基于这种需求，可将MPLS技术和HMIPv6协议采用一种松耦合的方式结合起来，为3G的接入网部分提供一种新的移动性管理方案。该方案不仅能够支持HMIPv6的快速切换算法，还能在节点发生越区切换时实现QoS保证。     

基于区分服务感知的MPLS网络流量分配方法

服务质量（Qos）和流量工程（TE）是在当今网络中提供实时应用业务的两种重要技术。多协议标记交换（MPLS）在IP网Qos提供和TE功能实现中起了关键作用。首先介绍了区分服务感知的流量工程（DS-TE），然后提出了一种基于DS-TE的网络流量分配新方法。给出了相关的数学模型，并进行了相应的仿真，仿真结果表明使用该方法实施DS-TE时，在满足不同业务的QoS同时能较好地均衡网络负荷。     

社会语义网社区发现标签传递算法研究

针对在线社会网络的特性和现有社区发现算法的不足,提出一种基于语义网技术的在线社会网络社区发现算法ISLPA(Improved Semantic Label Propagation Algorithm),即一种适用于大规模在线社会网络的社区发现和标识算法。ISLPA算法对语义标签算法SemTagP进行改进,在社区划分过程中将在线社会网络视为有向加权图,通过语义网和社会化标签技术,充分结合在线社会网络丰富的语义信息和网络拓扑特征进行社区划分。ISLPA算法不需要预先设定社区数量和大小,就能实现社区发现,并能根据标签自动识别划分的社区。算法接近线性时间复杂度,具有较高的效率。通过实验表明,ISLPA算法能有效划分和标识真实在线社会网络。     

Combining predictions in pairwise classification: An optimal adaptive voting strategy and its relation to weighted voting

Weighted voting is the commonly used strategy for combining predictions in pairwise classification. Even though it shows good classification performance in practice, it is often criticized for lacking a sound theoretical justification. In this paper, we study the problem of combining predictions within a formal framework of label ranking and, under some model assumptions, derive a generalized voting strategy in which predictions are properly adapted according to the strengths of the corresponding base classifiers. We call this strategy adaptive voting and show that it is optimal in the sense of yielding a MAP prediction of the class label of a test instance. Moreover, we offer a theoretical justification for weighted voting by showing that it yields a good approximation of the optimal adaptive voting prediction. This result is further corroborated by empirical evidence from experiments with real and synthetic data sets showing that, even though adaptive voting is sometimes able to achieve consistent improvements, weighted voting is in general quite competitive, all the more in cases where the aforementioned model assumptions underlying adaptive voting are not met. In this sense, weighted voting appears to be a more robust aggregation strategy.     

Directly fast detection of digoxin in the serum sample by the synthetic receptor sensor

A novel biosensor (the synthetic receptor sensor) employing the molecular imprinted technology for the digoxin analysis is investigated. The molecularly imprinted polymer (MIP) modified electrode can specifically bind to the analyte in the sample without sample pretreatment. The digoxin analyzed by the MIP sensor was carried out in 1 mM K₃Fe(CN)₆ solution with the cyclic voltammetry. In the system, the K₃Fe(CN)₆³⁻/Fe₂(CN)₆⁴⁻ redox couple was taking place. When the solution contains the digoxin, the MIP on the electrode will bind the digoxin. Further the redox system is interrupted and the peak current is decreased according to the digoxin concentration increasing. Digoxin is a glycosylated steroid-like drug. It is important for the heart disease treatment. However, since the digoxin toxic level is low, the drug remains in the blood sample must be monitored frequently. The device possesses many advantages, such as high specific recognition properties, good chemical and mechanical stability, simplicity and low cost of preparation, sensitive and label free determination. The reproducibility is good (CV < 5). The linear relationship between the digoxin concentration and the current is 1.28–128 nM, and a detection limit of 1.28 nM is achieved. The detection time is less than 5 min.     

The Slice Algorithm for irreducible decomposition of monomial ideals

Irreducible decomposition of monomial ideals has an increasing number of applications from biology to pure math. This paper presents the Slice Algorithm for computing irreducible decompositions, Alexander duals and socles of monomial ideals. The paper includes experiments showing good performance in practice.     

MSTP体系结构研究

随着IP数据、话音和图像等多种业务传输需求的不断提高,现有以承载话音为主要业务的城域网在容量以及接口能力上都已经无法满足业务传输与汇聚的要求。以SDH为基础的多业务传输平台能够克服传统城域网的缺点,可以更有效地支持分组数据业务,并有助于实现从电路交换网向分组网的过度。介绍了MSTP的分类方法,给出了MSTP的分层结构,并对各功能模块的需求和特点进行了详细分析。