Rupture Mechanics of Vimentin Intermediate Filament Tetramers

Together with the globular proteins, microtubules and microfilaments, intermediate filaments are one of the three major components of the cytoskeleton in eukaryotic cells. They consist of a dimeric coiled-coil building block, assembled in a very precise, hierarchical fashion into tetramers, forming filaments with characteristic dimensions on the order of several micrometers. Here we focus on the theoretical analysis of the deformation mechanics of vimentin intermediate filaments, a type of intermediate filament expressed in leukocytes, blood vessel endothelial cells, some epithelial cells, and mesenchymal cells such as fibroblasts. The main contribution of this paper is the study of the rupture mechanics of intermediate filament tetramers, representing an assembly of two dimers, by utilizing a statistical Bell model adapted to describe the rupture dynamics of intermediate filaments. Possible deformation mechanisms, including interdimer sliding and uncoiling of the dimer, are illustrated in light of the interdimer adhesion and dimer stability. The analysis reveals that the dominating deformation mechanism depends critically on the interdimer adhesion, solvent condition, and deformation rate.     

Interactive effects from self-reported physical and psychosocial factors in the workplace on neck pain and disability in female office workers

This study explored the interaction between physical and psychosocial factors in the workplace on neck pain and disability in female computer users. A self-report survey was used to collect data on physical risk factors (monitor location, duration of time spent using the keyboard and mouse) and psychosocial domains (as assessed by the Job Content Questionnaire). The neck disability index was the outcome measure. Interactions among the physical and psychosocial factors were examined in analysis of covariance. High supervisor support, decision authority and skill discretion protect against the negative impact of (1) time spent on computer-based tasks, (2) non-optimal placement of the computer monitor and (3) long duration of mouse use. Office workers with greater neck pain experience a combination of high physical and low psychosocial stressors at work. Prevention and intervention strategies that target both sets of risk factors are likely to be more successful than single intervention programmes.

Statement of Relevance: The results of this study demonstrate that the interaction of physical and psychosocial factors in the workplace has a stronger association with neck pain and disability than the presence of either factor alone. This finding has important implications for strategies aimed at the prevention of musculoskeletal problems in office workers.     

Preliminary study on the enhancement of WCDMA technology with SON functionality

This paper reports on work aimed at designing a dynamic system-level simulator for wireless telecommunication networks. Presented here are considerations devoted to the development of a software tool, a preliminary condition for the analysis of various technological aspects directed towards the enhancement of WCDMA (Wideband Code Division Multiple Access) technology by implementing SON (Self Organized Networks) functionality. The future broadening of such strategies to include multi-technology networks will be possible with the created methodology and software library. Compared to typical attempts in this research domain, which involve pure software representations of wireless system operations, the methodology offered in this paper creates a tool that has direct practical value, which is primarily based on operations on input data measured in an actual wireless telecommunications system. Thus, both detailed cases concerning wireless communication in a chosen region of the world and general ideas of a conceptual nature can be considered with the support of an IRSON (Integrated Research on SON) system-level simulator.     

Immigration and Construction: The Makeup of the Workforce in the Washington, D.C., Metropolitan Area

There are an estimated 11 million illegal immigrants currently residing in the United States. Of this population, research shows that approximately 19% work in the construction industry, comprising around 14% of all construction workforces. The Washington, D.C. metropolitan region has a unique makeup of workforces within the construction industry. Between September 2006 and February 2007, 896 construction workers from several projects in the Washington, D.C. metropolitan area participated in a survey. The study targeted the low-skilled, immigrant-saturated trades in construction. The most compelling finding in this study was that illegal immigrants make up a far greater proportion of the construction workers in low-skilled trades than indicated by national averages, 55% as compared to between 20 and 36% nationally. This will increase the impact of immigration and immigration reform substantially for the Washington, D.C. metropolitan.     

Natural Vibrations of Open-Variable Thickness Circular Cylindrical Shells in High Temperature Field

The feasibility of using the transfer matrix method (TMM) to analyze open-variable thickness circular cylindrical shells exposed to a high-temperature field is explored theoretically. In the approach to the problem, the thermal degradation (TG) of thermoelastic characteristics of the material is considered. Natural frequencies and mode shapes for the cylindrical shells are investigated in detail by combining the vibration theory with the TMM. The governing equations of vibration for this system are expressed by the matrix differential equations, and the coefficient matrices are derived. After the relationship between the transfer matrix and the coefficient matrix is established, the fourth-order Runge-Kutta method is used numerically to solve the matrix equation. Once the transfer matrix of single component has been obtained, the product of each component matrix can compose the matrix of the entire structure. The frequency equations and mode shape are formulated in terms of the elements of the structural matrices. Finite-element numerical simulation has validated the present formulas of natural frequencies. Numerical illustrations, supplying pertinent information on the implications of the TG, are presented for various curvatures, aspect ratios, boundary conditions, and thickness ratios, and the pertinent conclusions are outlined.     

Application of a SOM-Based Optimization Algorithm in Minimizing Construction Time for Secant Pile Wall

Construction time matters for activities where rental equipment must be used. The building of a secant pile wall requires the rental of equipment and finding the optimal sequence to minimize the construction time is one way to lower construction costs. In this study we develop an effective and efficient optimization algorithm, which we call self-organizing feature map (SOM)-based optimization (SOMO), to minimize the construction time. The algorithm is applied to a case study to obtain the optimal sequences for both primary and secondary bored piles for a secant pile wall. The new SOMO algorithm is developed based on the ability of the human brain to produce topologically ordered mapping, so as to exploit better solutions via updating the weighting vectors of the neurons in a self-organizing topological way that occurs in the evolution of the feature map for optimization. Given detailed building time of the 16 activities of each bored pile, we find that 143.92 h or 27.21% of the original construction can be saved. The optimal sequences for both primary and secondary bored piles are also determined. The practicability of the SOMO algorithm is substantiated.     

Inclusion of fatigue effects in human reliability analysis

The effect of fatigue on human performance has been observed to be an important factor in many industrial accidents. However, defining and measuring fatigue is not easily accomplished. This creates difficulties in including fatigue effects in probabilistic risk assessments (PRA) of complex engineering systems that seek to include human reliability analysis (HRA). Thus the objectives of this paper are to discuss (1) the importance of the effects of fatigue on performance, (2) the difficulties associated with defining and measuring fatigue, (3) the current status of inclusion of fatigue in HRA methods, and (4) the future directions and challenges for the inclusion of fatigue, specifically sleep deprivation, in HRA.     

Shrinkage, density, porosity and shape changes during dehydration of pumpkin (Cucurbita pepo L.) fruits

The aim of this work was to study the changes in volume, density, porosity and shape factors of pumpkin tissue during osmotic dehydration (OD) and air drying (AD). Pumpkin cylinders with length/diameter ratio of 5/3 were used. OD experiments were carried out with solutions of sucrose, sodium chloride and mixtures of both solutes at different temperatures. AD experiments were conducted at 70 °C. Volume of samples decreased linearly with weight reduction (WR). Bulk density varied in a restricted range (5-13%) during dehydration and for all the methods maximum values were found. Particle density increased during both processes. Porosity increased at advanced degrees of dehydration, showing a minimum value at the beginning of OD and AD. The proposed models to evaluate shrinkage, bulk and particle densities and porosity from WR were satisfactorily applied. Image analysis showed that shrinkage of samples during OD was isotropic. Pumpkin cylinders increased elongation and decreased roundness and compactness during osmotic dehydration.     

Measurement and Stochastic Computational Modeling of the Elastic Properties of Parallel Strand Lumber

This paper describes a model for the spatial variation of the elastic modulus of parallel strand lumber (PSL) that is based on bending experiments and also describes a validated stochastic computational model that incorporates orthotropic elasticity and uncertainty in strand geometry and material properties. The PSL exhibits significant variability both within members and between members, but this variability is less than that of equivalent sawn-wood members, and decreases with increasing member size. The correlation length of the elastic modulus is found to be several meters and is independent of the cross-sectional size. The variance of PSL elastic modulus is found to scale inversely with the number of strands in the cross section. The validated computational model is flexible enough to allow preliminary exploration of the properties of new mixes of species and strand sizes in PSL material design.     

Winning and positive affect can lead to reckless gambling.

Experiments 1 and 2 examined whether winning versus losing led to reckless betting for real prize money. Experiment 2 also assessed whether positive or negative emotions were linked to such reckless betting. College students were randomly assigned to experience primarily either wins or losses during the rigged first round of a computerized card tournament that had 2 independent rounds. For the second round, participants’ chip totals were reset and cards were dealt randomly. In Experiment 1 (N = 107), participants in the Initial-Winning, as compared with the Initial-Losing, condition bet more recklessly (i.e., bet too many chips when a loss was likely). Experiment 2 (N = 72) again showed that Initial-Winning participants bet significantly more recklessly than did Initial-Losing participants. It also revealed that positive affect was significantly positively correlated with such reckless betting. These findings have implications for understanding how college students, those at an age when they are especially vulnerable to problem gambling, can come to lose more money than they can afford. Initially winning and positive affect when gambling could be risk factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)