差异化可靠传输拥塞控制算法

随着网络通信技术和应用的快速发展, 应用程序提出越来越精细化、差异化的数据传输性能需求, 然而传统网络传输协议较低的灵活性导致其无法满足各类应用的差异化需求, 亟需研究差异化的可靠传输控制协议以适应未来场景. 本文提出一种差异化可靠传输协议, 并重点提出一种基于可靠度的差异化可靠传输拥塞控制机制, 为不同的可靠度差值设计不同的拥塞避免和拥塞恢复策略, 并通过带宽估计策略精准调节拥塞阈值. 经实验验证, 差异化可靠传输拥塞机制在传输效率方面相比基于丢包和基于时延的拥塞算法有较大提升, 同时实现了良好的公平性.     

基于WOSS的NS-Miracle水声信道模拟方法扩展

将世界海洋仿真系统(World Ocean Simulation System,WOSS)与声射线模型Bellhop结合并引入海洋噪声经验公式对NS-Miracle仿真系统的水声传输信道模拟方法进行扩展.为了验证扩展后的仿真系统,实验采用了基于水声信道特征经验模型、Bellhop射线模型及WOSS结合Bellhop射线...     

Boroleucine-Derived Covalent Inhibitors of the ZIKV Protease

The Zika virus (ZIKV) remains a potential threat to the public health due to the lack of both an approved vaccination or a specific treatment. In this work, a series of peptidic inhibitors of the ZIKV protease with boroleucine as P1 residue was synthesized. The highest affinities with K_i values down to 8 nM were observed for compounds with basic residues in both P2 and P3 position and at the N-terminus. The low potency of reference compounds containing leucine, leucine-amide or isopentylamide as P1 residue suggested a covalent binding mode of the boroleucine-derived inhibitors. This was finally proven by crystal structure determination of the most potent inhibitor from this series in complex with the ZIKV protease.