Research on virtual dynamic optimization design for NC machine tools

Virtual dynamic optimization design can avoid the repeated process from design to trial-manufacture and test. The designer can analyze and optimize the product structures in virtual visualization environment. The design cycle is shortened and the cost is reduced. The paper analyzed the peculiarity of virtual optimization design, and put forwards the thought and flow to implement virtual optimization design. The example to optimize the internal grinder was studied via establishing precise finite element model, modifying the layout of Stiffened Plates and designing parameters of the worktable, and using the technology of modal frequency revision and the technology of multiple tuned damper. The result of optimization design compared the new grinder with the original grinder shows that the entire machine＇s first orders natural frequency is enhanced by 17%, and the response displacement of the grinding-head has dropped by 28% under the first order natural frequency and by 41% under second order natural frequency. Finally, the dynamic performance of the internal grinder was optimized.     

回转轴运动精度的干涉测量与误差补偿分析

采用激光干涉仪检测混联数控机床回转轴的运动精度,达到对其综合评价的目的,为机床的运动精度误差补偿做准备.对雷尼绍激光干涉仪的结构和角度测量原理进行了详细探讨,分析了干涉仪在回转轴运动精度测量中的主要影响因素和误差诱因;作出了角度测量中正弦近似误差特性曲线,并提出了该测量误差的数学模型;讨论了激光波长补偿的机理,提出了一种通用、简便易行的回转轴角位移精度检测方法.     

Identification of Spliceogenic Variants beyond Canonical GT-AG Splice Sites in Hereditary Cancer Genes

Pathogenic/likely pathogenic variants in susceptibility genes that interrupt RNA splicing are a well-documented mechanism of hereditary cancer syndromes development. However, if RNA studies are not performed, most of the variants beyond the canonical GT-AG splice site are characterized as variants of uncertain significance (VUS). To decrease the VUS burden, we have bioinformatically evaluated all novel VUS detected in 732 consecutive patients tested in the routine genetic counseling process. Twelve VUS that were predicted to cause splicing defects were selected for mRNA analysis. Here, we report a functional characterization of 12 variants located beyond the first two intronic nucleotides using RNAseq in APC, ATM, FH, LZTR1, MSH6, PALB2, RAD51C, and TP53 genes. Based on the analysis of mRNA, we have successfully reclassified 50% of investigated variants. 25% of variants were downgraded to likely benign, whereas 25% were upgraded to likely pathogenic leading to improved clinical management of the patient and the family members.     

改进缺陷,套刻和聚焦性能的第五世代浸没式曝光系统

论述了第五世代双扫描平台浸液式扫描曝光机的性能和进展。表明了在高速扫描状态下有生产价值的套刻和聚焦性能的实现。浸液式设备更多的关键部分与缺陷有关,而且该机的改进是通过有生产价值的缺陷水平方面来体现的。为了保持这种缺陷水平的改进效果,需要在圆片应用中进行专门稳定的测量。特加是边缘空泡除去(EBR)设计和圆片斜面良流线性是很重要的。     

基于审计方法的通用信息安全风险评估的设计

提出一种基于审计控制环的风险评估软件设计方法,在模块设计和评估自动化方面结合了最新的风险评估发展方向,在评估结果上能对措施的有效性进行预控制.     

软件需求工程-方法及工具评述

文中从需求工程的基本概念和研究内容出发,简单介绍了需求工程生命周期和需求规范等概念;比较全面地总结了现有的有代表笥的需求工程开发方法和工具,对其中一些重要的方法及工具作了分类和评述,并指出了需求工程方法和工具开发与实际领域相脱离等不足之处;最后探讨了需求工程研究现状中存在的一些主要问题及一些相应的解决方案。     

C反编译控制流恢复的形式描述及算法

反编译是软件逆向工程的重要组成部分。控制流恢复是Ｃ反编译的重要组成部分。本文首先描述了验证反编译结果与原程序功能等价的模型；其次从数学角度提出了Ｃ编译和反编译控制结构的数学模型并给出其性质；再次根据对Ｃ控制语句编译结果的分析，以扩展的ＢＮＦ形式描述了Ｃ控制语句反编译的约束属性方法；最后给出并说明了反编译控制流恢复的算法及其运行示例。     

Empirical Evaluation of CASE Tools Usage at Nokia

We presentthe results of a research work targeted to understanding thedomains and consequences of CASE tools usage in Nokia. We aimto evaluate the importance of the various CASE tools features,as rated by our developers, and how well such features are implementedin currently available CASE tools. A structured questionnairewas sent to our most experienced developers and CASE users. Fromthis survey, it emerged that CASE tools support is reputed mostuseful for the following functions: graphical drawing, automaticdocumentation generation and storage of diagrams. The resultshint to a mismatch between the features required by the developersand those offered by CASE products. Further research is neededbefore more definite conclusions can be drawn.     

知识辅助的数控机床ICAID系统设计与实现

以开发基于网络的数控机床工业设汁ICAID系统为目标,以工业设计过程中的知识研究为线索,进行了以获取设计过程隐含知识为目的的口语分析实验．从数控机床外观造型设汁所需的知识辅助角度提出了ICAID系统的知识处理模型、功能模块和设计流程规划,片在此基础上构建了系统的技术实现框架．通过若干知识表达和应用模块的具体实现,初步构建了具有知识辅助功能的数控机床工业设计ICAID系统。     

Web数据挖掘初探

Web上有海量的数据信息，对这些数据进行复杂的应用成了现令数据库技术的研究热点。这里对数据挖掘的基本概念、Web数据挖掘步骤、Web数据挖掘在三个研究领域的研究现状、发展及常用Web数据挖掘工具做了简单介绍，希望起到抛砖引玉作用。