Fractionated Irradiation of Right Thorax Induces Abscopal Damage on Bone Marrow Cells via TNF-α and SAA

Radiation-induced abscopal effect (RIAE) outside of radiation field is becoming more attractive. However, the underlying mechanisms are still obscure. This work investigated the deleterious effect of thoracic irradiation (Th-IR) on distant bone marrow and associated signaling factors by irradiating the right thorax of mice with fractionated doses (8 Gy × 3). It was found that this localized Th-IR increased apoptosis of bone marrow cells and micronucleus formation of bone marrow polychromatic erythrocytes after irradiation. Tandem mass tagging (TMT) analysis and ELISA assay showed that the concentrations of TNF-α and serum amyloid A (SAA) in the mice were significantly increased after Th-IR. An immunohistochemistry assay revealed a robust increase in SAA expression in the liver rather than in the lungs after Th-IR. In vitro experiments demonstrated that TNF-α induced SAA expression in mouse hepatoma Hepa1–6 cells, and these two signaling factors induced DNA damage in bone marrow mesenchymal stem cells (BMSCs) by increasing reactive oxygen species (ROS). On the other hand, injection with TNF-α inhibitor before Th-IR reduced the secretion of SAA and attenuated the abscopal damage in bone marrow. ROS scavenger NAC could also mitigated Th-IR/SAA-induced bone marrow damage in mice. Our findings indicated that Th-IR triggered TNF-α release from lung, which further promoted SAA secretion from liver in a manner of cascade reaction. Consequently, these signaling factors resulted in induction of abscopal damage on bone marrow of mice.     

基于ARM9的无线视频监控系统前端设计

基于ARM的视频监控系统在工业、军事、民用领域有着广泛的应用,其中视频采集的实现是视频监控系统中的关键技术。本设计的目的在于实现对模拟摄像机采集到的模拟视频信号进行A/D转换,压缩编码,以便于数字视频信号在无线网络上传输。模拟视频信号首先经过SAA7113H视频解码芯片来实现A/D转换,然后通过S3C2440处理器来实现对模拟视频信号压缩编码。经过实验证明本设计采集效果良好,完全能够满足视频监控系统的要求。     

基于USB总线的CCD图像采集系统

本文以USB2．0的控制器CY7C68013为核心设计了一个基于USB总线的CCD图像采集系统,其中包括图像采集的硬件结构和软件设计。该系统具有集成度高、存储量大、传输速度快等优点,用于CCD图像的实时采集可取得良好的效果。     

基于瓶装啤酒的在线容量检测方法及装置研究

开发了一个基于DSP的瓶装啤酒容量在线自动检测嵌入式系统。针对啤酒厂实际环境设计了光学系统,重点分析并解决了设计中遇到的摄像机成像速度、图像传输速度及生产线运动速度三者之间的匹配问题,很好地满足了生产线速度的实时性要求。同时给出一套实用的液位检测算法,能够自动识别瓶装啤酒容量。此系统的设计具有成本低、速度高及便携实用的特点。     

基于ARM9的远程图像无线监控系统

在实时性要求不高的条件下,为监控远程无人监守的设备,设计实现一种基于三星公司S3C2440嵌入式处理器的远程监控系统．利用GPRS／CDMA无线技术．通过Internet互联网实现远程无线控制．实践证明效果良好,ARM9嵌入式处理器可满足许多特殊需求,是实现图像监控系统的很好选择．     

用DSP技术从模拟视频信号中获取数字图像

TMS320C6x11系列DSP以其高速的运算性能、充足的存储空间、独特的并行处理机制使得其在图像处理领域有着十分广泛的应用前景,因此有必要为其提供一套有效的图像获取方案。本文给出一套从模拟制式视频信号中获取数字静态图像的方案,具有通用性好、占用CPU时间少、实时性强等特点。经实际系统验证,本方案每秒钟可以稳定地获取720×576幅面彩色图像6.25幅,具有很好的实用性。     

Hepatic and extrahepatic expression of serum amyloid A3 during lactation in dairy cows

Serum amyloid A3 (SAA3) is the predominant SAA isoform secreted by mammary epithelial cells in dairy cows; it is also expressed in bovine adipose tissue (AT). The adipokine SAA3 is linked to obesity and insulin resistance of AT and the respective inflammatory response, at least in mice. Dietary treatment with conjugated linoleic acids (CLA) reportedly also affects insulin sensitivity and inflammatory status in monogastrics. Both SAA3 and CLA thus seem to alter similar functions. Based on changes in insulin sensitivity and the inflammatory status throughout lactation, we hypothesized that the mRNA abundance of SAA3 in various tissues might be regulated as well and that CLA could be a modulator of SAA3 mRNA expression. In 2 trials, 21 pluriparous and 25 primiparous Holstein cows were fed 100 g/d of a CLA or a control fat supplement from d 1 to 182 or 105 postpartum, respectively. Biopsies from liver and subcutaneous (s.c.) AT from pluriparous cows and samples from 3 different visceral AT and 3 s.c. AT, muscle, mammary gland, and liver tissue from slaughtered primiparous cows were obtained. In an adipocyte cell culture system, cell samples were collected during differentiation of bovine preadipocytes at d 0, 2, 6, 8, 10, 12, and 13 relative to the onset of differentiation. The SAA3 mRNA abundance in tissues and in differentiating bovine preadipocytes was measured by real-time PCR. The presence of the SAA protein was confirmed by Western blotting. Treatment with CLA yielded only few and inconsistent effects on SAA3 mRNA abundance. In both trials, SAA3 mRNA peaked at d 1 postpartum in all tissues except in mesenteric AT, in which the change was not significant. The highest SAA3 mRNA expression was observed in the mammary gland, followed by omental AT. The SAA protein was present in the visceral and s.c. AT depots investigated. Adipocytes as one source of SAA3 were confirmed by the SAA3 mRNA profile in differentiating adipocytes. The longitudinal changes observed point to SAA3 being involved in the inflammatory situation around parturition.     

光谱预处理结合模拟退火算法的小麦粉面筋含量检测

为得到可靠的小麦粉中面筋含量定量分析模型,基于光谱预处理及模拟退火算法（simulated annealing algorithm,SAA）对近红外光谱（near infrared spectroscopy,NIR）进行优化处理。偏最小二乘（partial least squares,PLS）回归用于建立预测模型,以决定系数R2、校正均方根误差（root mean square error of calibration,RMSEC）、预测均方根误差（root mean square error of prediction,RMSEP）为指标,对比在不同光谱预处理条件下建立的回归模型与光谱预处理结合模拟退火算法优化处理条件下的回归模型。结果表明光谱预处理结合SAA-PLS模型能够有效提高模型的稳定性和预测能力,将R2从0.763?7提高到0.949?1、RMSEC从1.371?2降低到0.589?8、RMSEP从1.450?2降低到0.534?1。结果说明,光谱预处理结合模拟退火算法对光谱进行优化处理是可行的,模型预测能力和稳定性均优于未处理模型和仅进行光谱预处理的模型。     

基于机会约束理论的微电网随机优化调度

随着风能、太阳能等可再生能源的开发利用,基于分布式电源的微电网安全经济调度日益引起人们关注。本文考虑了风能和太阳能的随机性和互补性,以及储能蓄电池中能量的不确定性,提出在满足系统功率平衡约束和运行约束的条件下,建立基于机会约束理论的微电网随机经济优化模型。该模型以微电网用电总费用最小为目标函数,利用抽样平均近似(SAA)法将机会约束条件转化为确定性条件,并采用粒子群算法进行寻优求解。最后,通过对随机优化模型和确定性模型进行了对比,并研究了置信度水平和抽样次数对调度的影响,算例结果表明了该随机优化模型的合理性和有效性。