自调节软件

This paper introduces a new concept——Self-tuning software which has just been put forward recently abroad. It also surveys the development of the new thing.     

Differential regulation of redox proteins and chaperones in HbEβ-thalassemia erythrocyte proteome

Purpose: In (hemoglobin, Hb) HbEβ‐thalassemia, HbE (β‐26 Glu→Lys) interacts with β‐thalassemia to produce clinical manifestation of varying severity. This is the first proteomic effort to study changes in protein levels of erythrocytes isolated from HbEβ‐thalassemic patients compared to normal. Experimental design: We have used 2‐DE and MALDI‐MS/MS‐based techniques to investigate the differential proteome profiling of membrane and Hb‐depleted fraction of cytosolic proteins of erythrocytes isolated from the peripheral blood samples of HbEβ‐thalassemia patients and normal volunteers. Results: Our study showed that redox regulators such as peroxiredoxin 2, Cu‐Zn superoxide dismutase and thioredoxin and chaperones such as α‐hemoglobin stabilizing protein and HSP‐70 were upregulated in HbEβ‐thalassemia. We have also observed larger amounts of membrane associated globin chains and indications of disruption of spectrin‐based junctional complex in the membrane skeleton of HbEβ‐thalassemic erythrocytes upon detection of low molecular weight fragments of β‐spectrin and decrease in β‐actin and dematin content. Conclusion and clinical relevance: We have observed interesting changes in the proteomic levels of redox regulators and chaperons in the thalassemic hemolysates and have observed strong correlation or association of the extent of such proteomic changes with HbE levels. This could be important in understanding the role of HbE in disease progression and pathophysiology.     

一类不确定性鲁棒LQR的奇异值特性分析

针对系统矩阵存在的范数有界不确定性,基于一种鲁棒线性二次调节器(LinearQuadratic Regulators,LQR)的设计,利用其鲁棒回差方程,详细推导了这种鲁棒LQR灵敏度函数的奇异值最大值与规范LQR灵敏度函数的奇异值最大值之间的关系,证明这种鲁棒LQR相对于规范LQR具有较小的灵敏度函数的最大奇异值,灵敏度函数的奇异值特性分析说明这种鲁棒LQR设计相对规范LQR有较好的控制性能。表明灵敏度函数的奇异值特性分析,是一种有效的控制系统性能分析方法。     

参数自适应模糊PID控制器在温度控制系统中的应用

电阻炉模型参数具有随温度而变化的时变特性．当温度大范围变化时．采用常规PID控制方法不能满足较高工艺要求．为此，本文应用一种参数自适应模糊PID控制方法，并设计了基于单片机的温度控制硬件装置。实践证明该控制方法有较高的稳态精度和跟踪性。装置简单，运行效果较好。     

具有强相容参数估计的多变量自校正前馈控制器

本文提出了一种新的自校正前馈控制器.该控制器具有如下优点:1)可以控制具有任意传输延时结构的随机多变量系统;2)可以控制开环不稳定或非最小相位系统;3)不加积分作用可以自适应消除偏差和可测干扰对输出的影响,消除跟踪误差;4)具有全局稳定特性;5)参数估计具有强相容性.     

基于Fuzzy推理的自调整PID控制器*

本文提出一衙 新的基于Ｆｕｚｚｙ推理的ＰＩＤ自整定控制器。     

Exposure to Diflubenzuron Results in an Up-Regulation of a Chitin Synthase 1 Gene in Citrus Red Mite,Panonychus citri (Acari: Tetranychidae)

Chitin synthase synthesizes chitin, which is critical for the arthropod exoskeleton. In this study, we cloned the cDNA sequences of a chitin synthase 1 gene, PcCHS1, in the citrus red mite, Panonychus citri (McGregor), which is one of the most economically important pests of citrus worldwide. The full-length cDNA of PcCHS1 contains an open reading frame of 4605 bp of nucleotides, which encodes a protein of 1535 amino acid residues with a predicted molecular mass of 175.0 kDa. A phylogenetic analysis showed that PcCHS1 was most closely related to CHS1 from Tetranychus urticae. During P. citri development, PcCHS1 was constantly expressed in all stages but highly expressed in the egg stage (114.8-fold higher than in the adult). When larvae were exposed to diflubenzuron (DFB) for 6 h, the mite had a significantly high mortality rate, and the mRNA expression levels of PcCHS1 were significantly enhanced. These results indicate a promising use of DFB to control P. citri, by possibly acting as an inhibitor in chitin synthesis as indicated by the up-regulation of PcCHS1 after exposure to DFB.     

Automatic Voltage Regulator Design by Modified Discrete Integral Variable Structure Model Following Control

In power systems, the automatic voltage regulator (AVR) is designed to make the terminal voltage to accurately track the deviation of the reference voltage. To achieve the desired requirements, this paper proposes the modified discrete integral variable structure model following control (MDIVSMFC) approach. The MDIVSMFC approach comprises a reference model part for specifying the design requirements and a MDIVSC part for minimizing the errors between the plant and model. The non-ideal sliding motion is introduced to take the place of the ideal sliding motion in discrete-time systems. Its existence conditions are used to adapt the proposed approach to the discrete systems. The application of MDIVSMFC to an AVR design is developed. Procedures for determining the control function, the coefficients of the sliding surface and the integral control gain are also proposed in detail. Simulation results are compared with the IEEE type-I voltage regulator to demonstrate that the proposed scheme can achieve fast and robust responses.     

Implementation of self-tuning generalized predictive controllers for the process industry

This paper presents a set of simple Ziegler-Nichols-type functions for implementing generalized predictive controllers (GPCs). By using this set of functions, the implementation of GPCs is simplified considerably and the heavy computational requirements needed are avoided. The functions have been obtained for a CARIMA model that is valid for most processes in industry, as is the case of plants whose behaviour can be described in terms of a static gain, time constant and effective dead time.     

High voltage generator for the power supply of photomultipliers in the time of flight system of Alpha Magnetic Spectrometer-2 experiment

In this report, the behaviour of the first prototype high voltage generator (HVG) that might be used in the time of flight (TOF) system for the AMS-2 experiment is described. The system receives a positive continuous voltage about 100–120 V as input, and it provides a programmable negative continuous voltage from −1600 to −2400 V as output, versus a total load of 50 MΩ. The most important aspect is the absence of a transformer which usually is used in the step-up DC–DC converters. In the TOF system of alpha magnetic spectrometer (AMS)-2 experiment there is a big magnetic field, higher than 2 kG, that does not allow to use a transformer, therefore this prompted us to use the Cockroft–Walton system. The power consumption is about 300 mW and the peak-to-peak high frequency ripple is lower than 0.3% of the output high voltage. We also estimated the reliability of the HVG and we obtained a failure probability lower than 0.5% after three years of continuous functioning. Besides, in this report, much importance was given to the calculation of a simple model of the system to estimate the stability margins.