负载锌酞菁的二氧化硅纳米载体在光动力疗法的应用

在传统介孔二氧化硅合成的基础上,以壳聚糖的Ca2+溶液作为扩孔剂,利用层层自组装技术包裹CS(壳聚糖)/HA(透明质酸)层,制备得到了可降解的大孔二氧化硅[DMSNs@(CS/HA)],在DMSNs@(CS/HA)上负载疏水性药物锌酞菁(ZnPc),得到了负载锌酞菁的二氧化硅纳米载体[DMSNs@(CS/HA)@ZnPc]。将其应用于光动力学抗肿瘤研究。采用SEM、TEM、FTIR、XRD、UV-vis、N2吸附等温线和荧光成像技术对DMSNs@(CS/HA)和DMSNs@(CS/HA)@ZnPc进行了物相、形貌、孔径分布、结构、肿瘤光动力学治疗测试。结果表明,当DMSNs@(CS/HA)纳米载体的质量浓度为50 mg/L,Hela细胞的相对存活率高达93.2%,而负载ZnPc并在近红外光照10 min后,细胞存活率则锐减到36.2%。细胞存活率及其荧光成像实验均表明DMSNs@(CS/HA)纳米载体具有良好的生物相容性,可有效负载ZnPc,并应用于近红外照射下光动力学抗肿瘤。     

Sensory-motor enhancement in a virtual therapeutic environment

The sensory-motor skills of persons with neuromuscular disabilities have been shown to be enhanced by intensive and repetitive therapeutic interventions. This paper describes a form of low immersion virtual reality and a prototype, open source system that allow a user with significant physical disability to actively interact with computer-generated objects whose behaviors promote a game-like interaction. Unlike fully immersive and haptic virtual reality, this approach frees the user from head-mounted displays and gloves. It extracts the user’s real-time silhouette from the output of a remote video camera and uses that two-dimensional outline to interact with graphical objects on screen. In contrast to video games that have been modified with specialized interfaces, this virtual interaction system promotes the repetitive use of goal directed movements of the arms and body, which are essential to promote cortical reorganization, as well as discourage unwanted changes in muscle tissue that result in contracture. A prototype system demonstrates the potential of low immersion technology to motivate users and encourage participation in therapy. It also offers the potential of accommodating the sensory-motor skills of individuals with very significant impairment. The behaviors of the computer-generated graphics can be altered to allow use by those with very limited range of motion and/or motor control. These behaviors can be adjusted to provide a continuing challenge as the user’s skills improve. This prototype is described in terms of functional capabilities that include a silhouette extraction from a video image, and generation of graphical objects that interact with the silhouette. The work is extended with a discussion of a more sophisticated region of interest detection algorithm that can select specific parts of the body.     

图像引导放疗中的锥束CT灌注成像方法

为了实现图像引导放疗与功能成像结合的功能图像引导放疗,研究运用图像引导放疗中的锥束CT影像设备进行CT灌注成像的可能性。为了解决锥束CT不能快速成像,进而不能获取准确的体素时间-密度曲线(IDC)的问题,提出了一种基于投影数据的体素密度建模方法。首先,运用计算机仿真技术模拟出锥束CT投影数据;然后,对各体素密度值进行数学建模;最后,利用计算机最优化值求解技术,编程实现模型具体参数的计算。实验证明,该模型得到的TDC和DCE-CT实测获得的TDC有很高的吻合度。该模型实现图像引导放疗中的锥束CT灌注成像是可行的。     

The Satisfaction With Therapy and Therapist Scale--Revised (STTS-R) for group psychotherapy: Psychometric properties and confirmatory factor analysis.

Patients' level of satisfaction with their therapeutic experience is a concept that is important for understanding treatment efficacy; however, patient satisfaction has received little empirical attention. The Satisfaction With Therapy and Therapist Scale (STTS) developed for group psychotherapy by T. P. S. Oei and G. J. Shuttlewood (1999) was designed to assess patients' level of satisfaction with their therapeutic endeavor. This article aims to strengthen the STTS's psychometric properties by using confirmatory factor analysis (CFA) with a large sample of patients with mood and anxiety disorders. Outpatients (N = 344) took part in the study. Exploratory factor analysis indicated 2 conceptually coherent factors that accounted for 66.9% of the variance. The 2 factors, which were similar to those found in Oei and Shuttlewood (1999), namely, Satisfaction With Therapy and Satisfaction With Therapist, were replicated. CFA revealed a 2-factor solution to be the best-fitting model. Overall, this article demonstrated that the STTS-R has sound psychometric properties and would serve as a useful instrument in assessing a patient's level of satisfaction with both group therapy and therapist in research as well as in clinical settings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Therapy makeup improves quality of life of patients with skin diseases – covering foundations created by integration of medical and beauty care for severe skin color problems

IFSCC Magazine , 11 (2008) (1) 11–18
In collaboration with medical institutions, we have been providing makeup guidance to people with facial skin color problems under the name >>therapy makeup«. The aim of therapy makeup is to reduce the anxiety and tension associated with the appearance of people with skin color problems and to provide psychological support, thereby helping them live more normal lives. Ota's nevus (blue birthmarks) and port-wine stain (red birthmarks) the leading causes of abnormal skin coloration. We have already developed covering foundations for Ota's nevus and port-wine stain using a light-filtering technology. Another common cause of abnormal skin coloration is vitiligo (white patches). Vitiligo cannot be adequately covered by conventional cosmetic foundations. Therefore, we developed a new covering foundation for vitiligo based on optical characteristics. Moreover, the effects of makeup on the psychology of patients with vitiligo were objectively evaluated using psychometrically established quality of life indices. It was demonstrated that makeup helped to alleviate the psychological anxiety and tension of patients, resulting in improvement of social relationships and self-esteem.
The integration of medical care and beauty care enables therapy makeup to improve quality of life of patients with skin color disorders.     

Behavior Therapists' Professional Behaviors: A Survey Study.

Behavior therapy is often associated with an empirical-clinical methodology (Goldfried & Davison, 1976) and utilization of clinical interventions that have received research validation. Yet the extent to which self-defined behavior therapists follow these guidelines is not known. To initiate the present study, a survey was made of a random sample of 250 members of the Association for Advancement of Behavior Therapy, with a 64% return rate. The results suggest that behavior therapists do not operationalize their theoretical guidelines in many of their actual clinical cases. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

奥多摩森林疗法之路

在日本,森林疗法的相关研究已近30年,在近些年的研究分析中,森林疗法的疗效已经得到科学证实。由此,日本社会引发了对人工林活用的重新审视。通过介绍位于日本东京都西多摩郡奥多摩町的奥多摩森林疗法之路的建设项目,深入浅出地分析了项目设计过程的整体思路以及思考重点。探讨了如何充分利用自然原始条件,创造可供人们康复治疗的人工林设...