Therapy makeup improves quality of life of patients with skin diseases – covering foundations created by integration of medical and beauty care for severe skin color problems

IFSCC Magazine , 11 (2008) (1) 11–18
In collaboration with medical institutions, we have been providing makeup guidance to people with facial skin color problems under the name >>therapy makeup«. The aim of therapy makeup is to reduce the anxiety and tension associated with the appearance of people with skin color problems and to provide psychological support, thereby helping them live more normal lives. Ota's nevus (blue birthmarks) and port-wine stain (red birthmarks) the leading causes of abnormal skin coloration. We have already developed covering foundations for Ota's nevus and port-wine stain using a light-filtering technology. Another common cause of abnormal skin coloration is vitiligo (white patches). Vitiligo cannot be adequately covered by conventional cosmetic foundations. Therefore, we developed a new covering foundation for vitiligo based on optical characteristics. Moreover, the effects of makeup on the psychology of patients with vitiligo were objectively evaluated using psychometrically established quality of life indices. It was demonstrated that makeup helped to alleviate the psychological anxiety and tension of patients, resulting in improvement of social relationships and self-esteem.
The integration of medical care and beauty care enables therapy makeup to improve quality of life of patients with skin color disorders.     

立体适形放疗与常规放疗对老年非小细胞肺癌的疗效比较

比较立体适形放疗与常规放疗对老年非小细胞肺癌的疗效,结果表明:立体适形放疗的治疗效果更有优势。     

图像引导放疗中的锥束CT灌注成像方法

为了实现图像引导放疗与功能成像结合的功能图像引导放疗,研究运用图像引导放疗中的锥束CT影像设备进行CT灌注成像的可能性。为了解决锥束CT不能快速成像,进而不能获取准确的体素时间-密度曲线(IDC)的问题,提出了一种基于投影数据的体素密度建模方法。首先,运用计算机仿真技术模拟出锥束CT投影数据;然后,对各体素密度值进行数学建模;最后,利用计算机最优化值求解技术,编程实现模型具体参数的计算。实验证明,该模型得到的TDC和DCE-CT实测获得的TDC有很高的吻合度。该模型实现图像引导放疗中的锥束CT灌注成像是可行的。     

The impact of child parent relationship therapy on child behavior and parent-child relationships: An examination of parental divorce.

The current study used a mixed methodological approach to examine the impact of Child-Parent-Relationship Therapy (CPRT) on divorced parents and their children. Specifically, in the present study, the authors investigated parents' perceptions of the impact of CPRT on the parent, the child, and the parent–child relationship. CPRT was found to be helpful in reducing parenting stress and child behavior problems. Parents also reported that CPRT helped them feel more connected to their children and provided them with new tools for parenting. The results of the current study add to the current literature on divorce, affirming that CPRT may be an effective intervention for children of divorce. Limitations of the study and implications for future research are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

治疗急性早幼粒细胞白血病的几个问题

急性早幼粒细胞白血病(APL)为急性髓系白血病的一个亚型,以进展快,易发生弥散性血管内凝血(DIC)和死亡率高为特征.95%以上APL患者有典型染色体易位t(15;17)形成PMLRARα融合基因.1986年以来,中国首创以全反式维甲酸(ATRA)和亚砷酸(ATO)治疗APL,使APL的转归大大改观,成为仅用药物可治愈的AML.结合作者经验讨论治疗APL中的有关问题.     

骨化三醇对实验性自身免疫性脑脊髓炎的治疗作用及相关机制

目的探讨骨化三醇(Calcitriol)对实验性自身免疫性脑脊髓炎(Experimental autoimmune encephalomyelitis,EAE)的治疗作用及相关机制。方法用含200μg髓鞘少突胶质细胞糖蛋白35-55肽段(Myelin oligodendrocyte glycoprotein 33-35,MOG33-35)、250μg结核菌素的50μl弗氏不完全佐剂(IFA)皮内免疫C57BL/6小鼠,并分别于免疫当天和第2天注射百日咳毒素,建立EAE实验性动物模型(EAE组);骨化三醇组从免疫当天起隔日腹腔注射骨化三醇100 ng进行治疗,观察两组小鼠临床评分的差异;于EAE发病高峰期处死小鼠,取脊髓及淋巴结,通过HE及LFB染色观察脊髓中炎细胞浸润及髓鞘脱失;采用流式细胞术检测两组淋巴细胞CD4+T细胞亚型的分布。结果与EAE组比较,骨化三醇组发病延缓且发病较轻,临床评分差异有统计学意义(P<0.05或P<0.01或P<0.001);骨化三醇组较EAE组小鼠脊髓白质炎性细胞浸润明显减少,脱髓鞘斑块明显减轻;骨化三醇组与EAE组相比,Th17细胞亚群明显受到抑制(P<0.05),而Th2和Treg细胞水平明显升高(P均<0.05)。结论骨化三醇可以延缓EAE发病,减轻临床症状及病理改变,并能够通过调节CD4+T细胞亚群平衡,即抑制Th17细胞,上调Th2和Treg细胞水平发挥对EAE的预防和治疗作用。     

治疗性干细胞产品的相关风险因素

近年来国内外以干细胞为主的细胞治疗研究发展迅速,在治疗退行性疾病、缺血性心脑血管疾病、肝硬化及糖尿病等领域已开展了多项临床试验研究,但作为新型治疗性产品,干细胞产品在治疗的安全性和有效性方面还存在若干风险因素。本文对常见的干细胞种类、特性以及与临床应用相关的内在和外在风险因素进行了综述,旨在以现有的理论和技术条件,探讨治疗性干细胞产品基本的质量控制要求和策略。     

What makes group MET work? A randomized controlled trial of college student drinkers in mandated alcohol diversion.

Nationally, college drinkers exhibit the highest rates of alcohol consumption and represent the largest percentage of problem drinkers. Group motivational enhancement therapy (GMET) has been found to catalyze problem drinking reductions among college student samples. Although research supporting the use of single-session GMET in college samples (general and mandated) is emergent, no studies have evaluated a comprehensive model of the potential active ingredients of this group intervention. College students (N = 206; 88% White; 63% men; M age = 18.6) mandated to a university alcohol diversion program were randomly assigned to 1 of 3 conditions: the standard-of-care 2-session “Focus on Alcohol Concerns” education group (FAC), a single GMET, or a single alcohol information-only control group (AI) to evaluate the role of 5 putative mediators: readiness to change, self-efficacy, perceived risk, norm estimates, and positive drinking expectancies. At 3- and 6-month follow-ups, GMET students demonstrated greater reductions in problem drinking outcomes (drinks per drinking day, hazardous drinking symptoms, and alcohol-related problems). Of the 5 mediators proposed, only self-efficacy emerged as a significant mediator. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dissemination and effectiveness of multisystemic treatment in New Zealand: A benchmarking study.

The transportability of Multisystemic Therapy (MST) for the treatment of juvenile offenders in a community-based context was examined in the current study. Results of this New Zealand study showed that significant pre- to posttreatment improvements occurred on most indicators of ultimate (i.e., offending behavior) and instrumental (i.e., youth compliance, family relations) treatment outcomes. Reductions in offending frequency and severity continued to improve across the 6- and 12-month follow-up intervals. In comparison to benchmarked studies, the current study demonstrated a more successful treatment completion rate. Additionally, overall treatment effect sizes were found to be clinically equivalent with the results of previous MST outcome studies with juvenile offenders and significantly greater than the effect sizes found in the control conditions. The findings of this evaluation add to the growing body of evidence that supports MST as an effective treatment for antisocial youth. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

压电驱动微喷雾化器的研制及实验研究

作为一种重要的非注射给药途径，雾化吸入治疗方法具有起效快，药物毒、副作用小等特点，因此被越来越广泛地采用。基于压电驱动喷雾打印机工作基本原理，利用微机加工技术，研制了一种压电驱动微喷雾化器。流量、雾粒的直径和速度是微喷雾化器的重要指标，文中采用相关的仪器分别对这些指标进行了测试。由测试结果可知，微喷雾化器产生的雾粒的直径和速度分布集中，且雾粒直径和速度比较适合于雾化吸入治疗，可能成为一种重要的雾化吸入治疗装置。