快中子治癌束剂量特性研究

我国第一台中子治癌装置由３５ＭｅＶ质子＋Ｂｅ反应产生的快中子束已在临床中取得初步结果。其剂量测试系统的监测室积分电荷－标准体模内中子吸收剂量校正因子ｋ＿（ｃｏｒ）值，在标准源皮距（１３７，３ｃｍ）、标准射野（９ｃｍ×９ｃｍ）和深度９ｃｍ条件下测得，在半年内２０次测量的相对标准差为±０．６３％。本文研究了不同射野尺寸对水模体内中子束深部剂量曲线的影响，大的射野尺寸将获得较高深部剂量。对于上述标准射野和源皮距，１０ｃｍ深处相对水模体前表面的剂量为５２％，与美国费米实验室相近几何条件下测得的中子束的相时深部剂量（６３％）相近。离轴比为１０．５％，略优于费米实验室的（１４／）。     

钴疗机漏射线照射量率的空间分布

本文简要介绍了对五种型号钴疗机在“开”位时机头漏射线照射量率 X_(γ,θ,ψ)空间分布的测量结果,并给出了估算 X_(γ,θ,ψ)的经验公式,可为钴疗机房屏蔽设计和辐射防护监督提供参考。     

The role of presence in the level of anxiety experienced in clinical virtual environments

Recent reviews point towards that Virtual Reality Exposure Therapy (VRET) can be an effective medium to provide exposure therapy for anxiety disorders. The concept of presence, usually defined as the sense of being inside the virtual environment, has been considered the principal mechanism that leads to the experience of anxiety in clinical virtual environments. The present study sought to examine the relationship between sense of presence and in-session anxiety in a sample of 210 students showing high and low test anxiety when exposed to both clinical and non-stressful virtual environments. This is the largest study conducted to date with the aim of examining the relationship between presence and anxiety in clinical virtual environments, and the first to explore separately the relationship between presence and state-anxiety in phobic and non-phobic participants. The results suggest that presence was not related to anxiety in a non-stressful environment. It was also found that although presence is related to anxiety in both groups of students when exposed to clinical virtual environments, this relationship was clearly stronger for high test anxiety students. This line of research will broaden our understanding of the mechanisms that lead to the efficacy of VRET.     

现代医院环境设计新探索--对"艺术治疗学"的借鉴

随着社会的发展和我国人口结构老龄化的到来,医院的服务范围不断扩大,现代医院的功能已从单纯的医治病患发展到融医治、科研教学、康复疗养、保健等功能于一体。为了适应医院功能的多元化,医院建筑和医院环境设计应当不断探索和发展新的设计理念。艺术治疗就是以艺术形象作为媒介进行心理治疗。它运用的是视觉形象,通过利用患者、治疗师和艺术形象在时间和空间意义上形成的感知,帮助患者深入自己的潜意识,激发潜意识的积极创造性,帮助病人建立自信心,达到治疗或帮助治疗的效果。在医院建筑设计、医院环境设计中引入艺术治疗具备很好的参考借鉴价值。     

Effect of α-Tocopherol During In Vitro Ozonation of Methyl Linoleate: Its Implication in Ozone Therapy

Systemic ozone therapy is widely used as an oxidant therapy to treat many conditions and diseases. It is known that ozone therapy acts through a transient oxidative stress produced by lipid ozonation products. The convenience of supporting patients with antioxidants during systemic ozone therapy applications is now under discussion. We studied the reaction of linoleate (one of the main constituents of cellular membranes and plasma phospholipids) with ozone in presence or absence of α-tocopherol, in order to explore whether the combination of ozone and antioxidant has some effect on fatty acid ozonation products. Proton nuclear magnetic resonance spectroscopy (¹H NMR) was used for following the reaction between 4.8mol mmol of methyl linoleate and 2.08 or 4.32mmol of ozone, with addition of different amounts of α-tocopherol (0.10, 0.18, and 0.26μmol). Ozonide (δ=5.15ppm) and aldehydes (δ=9.63ppm and δ=9.74ppm) intensities from ¹H NMR signals markedly decreased with α-tocopherol addition. When αtocopherol is absent, the intensities from olefinic proton signals diminished with ozone concentration increment; however, with αtocopherol in the mixture a smaller decrement was achieved. No detectable signals were found with the ozonation of α-tocopherol without methyl linoleate in the reaction mixture. These results suggest that α-tocopherol reacts with those products released from the reaction of ozone with methyl linoleate. This fact points out that antioxidant supplementation during systemic ozone therapy (major and minor autohemotherapy, rectal insufflation, and so forth) can be detrimental toward achieving the needed transient oxidative stress responsible for biological activities.     

Identification of SARS-CoV-2 by gold nanoparticles

The SARS-CoV-2 outbreaks highlighted the need for effective, reliable, fast, easy-to-do and cheap diagnostics procedures. We pragmatically experienced that an early positive-case detection, inevitably coupled with a mass vaccination campaign, is a milestone to control the COVID-19 pandemic. Gold nanoparticles (AuNPs) can indeed play a crucial role in this context, as their physicochemical, optics and electronics properties are being extensively used in photothermal therapy (PTT), radiation therapy (RT), drug delivery and diagnostic. AuNPs can be synthesized by several approaches to obtain different sizes and shapes that can be easily functionalized with many kinds of molecules such as antibodies, proteins, probes, and lipids. In addition, AuNPs showed high biocompatibility making them useful tool in medicine field. We thus reviewed here the most relevant evidence on AuNPs as effective way to detect the presence of SARS-CoV-2 antigens. We trust future diagnostic efforts must take this ‘old-fashioned’ nanotechnology tool into consideration for the development and commercialization of reliable and feasible detection kits.     

Strategies to Overcome the Barrier of Ischemic Microenvironment in Cell Therapy of Cardiovascular Disease

The transplantation of various immune cell types are promising approaches for the treatment of ischemic cardiovascular disease including myocardial infarction (MI) and peripheral arterial disease (PAD). Major limitation of these so-called Advanced Therapy Medicinal Products (ATMPs) is the ischemic microenvironment affecting cell homeostasis and limiting the demanded effect of the transplanted cell products. Accordingly, different clinical and experimental strategies have been evolved to overcome these obstacles. Here, we give a short review of the different experimental and clinical strategies to solve these issues due to ischemic cardiovascular disease.     

中医辨证论治尘肺188例分析

目的总结中医辨证论治尘肺的经验。方法收集临床中医辨证论治尘肺病例188例分析。结果中医辨证论治尘肺总有效率达95.71%。结论中医辨证论治尘肺的疗效明显。     

外用咪喹莫特治疗扁平疣的疗效观察

目的探讨外用5%咪喹莫特乳膏(艾达乐)治疗扁平疣的有效性和安全性。方法选择扁平疣患者64例,分成2组,分别给予单纯外用咪喹莫特、外用0.025%维甲酸软膏3个月,期间定期复诊,记录患者的药物反应、皮疹变化情况。结果各组患者有效率分别为79.4%、73.3%。各组治疗前与治疗后的皮损数量有统计学意义(P<0.05);两组疗效之间无统计学差异。无严重不良反应发生。结论外用5%咪喹莫特乳膏(艾达乐)治疗扁平疣安全有效。     

飞行员高血压药物治疗前后立位耐力和+Gz耐力观察

目的观察飞行员患高血压病及药物治疗后立位耐力和＋Gz耐力的变化。方法选择10例患高血压病的歼f强）击机飞行员,平均年龄（36&#177;6）岁,经临床检查未发现心脑血管并发症,在药物治疗前和服降血压药血压恢复正常后分别进行20min立位耐力试验和＋Gz耐力试验。结果药物治疗前立位耐力试验显示,平卧位平均血压为f147&#177;16／92&#177;10）mmHg（1mmHg=0．133kPa）,立位（150&#177;18／99&#177;12）mmHg,卧立位舒张压差异有统计学意义（P〈0．01）;1例立位耐力试验结果阳性,5例＋Gz耐力未达到所飞机种要求。降压药物治疗后,平卧位血压（131&#177;10／80&#177;7）mmHg,立位（130&#177;8／87&#177;3）mmHg,较治疗前均明显下降（P〈0．01,P〈0．05）,立位耐力试验均为阴性;3例＋Gz耐力未能达到所飞机种要求。结论高血压病对立位耐力和＋Gz耐力有不利影响;药物治疗后＋Gz耐力改善与病情和用药种类、剂量有关。