外用咪喹莫特治疗扁平疣的疗效观察

目的探讨外用5%咪喹莫特乳膏(艾达乐)治疗扁平疣的有效性和安全性。方法选择扁平疣患者64例,分成2组,分别给予单纯外用咪喹莫特、外用0.025%维甲酸软膏3个月,期间定期复诊,记录患者的药物反应、皮疹变化情况。结果各组患者有效率分别为79.4%、73.3%。各组治疗前与治疗后的皮损数量有统计学意义(P<0.05);两组疗效之间无统计学差异。无严重不良反应发生。结论外用5%咪喹莫特乳膏(艾达乐)治疗扁平疣安全有效。     

飞行员高血压药物治疗前后立位耐力和+Gz耐力观察

目的观察飞行员患高血压病及药物治疗后立位耐力和＋Gz耐力的变化。方法选择10例患高血压病的歼f强）击机飞行员,平均年龄（36&#177;6）岁,经临床检查未发现心脑血管并发症,在药物治疗前和服降血压药血压恢复正常后分别进行20min立位耐力试验和＋Gz耐力试验。结果药物治疗前立位耐力试验显示,平卧位平均血压为f147&#177;16／92&#177;10）mmHg（1mmHg=0．133kPa）,立位（150&#177;18／99&#177;12）mmHg,卧立位舒张压差异有统计学意义（P〈0．01）;1例立位耐力试验结果阳性,5例＋Gz耐力未达到所飞机种要求。降压药物治疗后,平卧位血压（131&#177;10／80&#177;7）mmHg,立位（130&#177;8／87&#177;3）mmHg,较治疗前均明显下降（P〈0．01,P〈0．05）,立位耐力试验均为阴性;3例＋Gz耐力未能达到所飞机种要求。结论高血压病对立位耐力和＋Gz耐力有不利影响;药物治疗后＋Gz耐力改善与病情和用药种类、剂量有关。     

Applicability of cognitive-behavior therapy with American Indian individuals.

There is little empirical evidence to support the claim that cognitive- behavior therapy (CBT) is an especially suitable treatment for culturally diverse clients. The purpose of this study was to compare the applicability of CBT in a community sample of European American and American Indian individuals. Participants completed the Cognitive Behavior Therapy Applicability Scale (CBT-AS), in which they rated their preference for characteristics consistent with three tenets of CBT. European Americans rated a stronger preference for CBT's focused in-session behavior and structured therapeutic relationship than did American Indians. Both groups rated the active stance domain of CBT as mutually acceptable. On the basis of the findings, several modifications to CBT for therapists working with American Indian clients are proposed for future investigation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The future of positive therapy.

Responds to commentary by S. J. Lopez and B. A. Kerr (see record 2006-07640-002) on the current author's original article (see record 2006-07640-001). In their commentary on strength-centered therapy (ST), Lopez and Kerr (2006) called for an open-source approach to developing positive psychological practices. In this rejoinder, the author responds to their comments, provides clarifications on ST, and discusses the future of positive therapy. Specifically, the author calls for future scholarship to address (1) the contributions of social constructionist therapies, (2) positive systemic influences in psychotherapy, and (3) diverse conceptualizations of strengths and optimal human functioning. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

原发性纵隔大B细胞淋巴瘤研究进展

原发性纵隔大B细胞淋巴瘤(PMBCL)是弥漫大B细胞淋巴瘤(DLBCL)的一种特殊类型,具有独特的临床表现及病理学、分子生物学特征.目前尚无标准的治疗方案,回顾性分析表明第三代的化疗方案优于CHOP方案,利妥昔单抗的应用缓解了这种差异,是否需要接受联合放疗尚无定论.未来将脱氧葡萄糖-正电子发射计算机断层显像(FDG-PET)用于PMBCL的疗效评估,如果能提供可靠的预后信息,就可以减轻治疗强度.     

老年急性髓细胞白血病的临床、生物学特征及治疗进展

急性髓细胞白血病(AML)的诸多预后不良因素中,年龄≥60岁是一个重要的不良预后指标.原因除了与老年患者本身的生理特点有关,更重要的是由于其白血病细胞的生物学特征与青年患者显著不同.现就老年AML患者的临床、生物学特征及在此基础上的治疗进展进行综述.     

Robot acceptance model for care (RAM-care): A principled approach to the intention to use care robots

Robots are emerging in welfare services, and organizations require information on whether novel technologies are approved among staff. On the basis of technology acceptance theories, this study proposes a model that adds a principled approach to the intention to use care robots. Data of 544 professionals with care robot experience were collected. The use intention was predicted by usefulness, enjoyment, social influence, and attitude. Respondents who found robots useful and accepted by their colleagues were more likely to view robot use as consistent with their personal values. The care robot acceptance model supports consideration of the profession-specific context in robotization.     

皖南地区人群131I治疗甲状腺功能亢进症的疗效及其影响因素

目的: 评价放射性¹³¹I 治疗Graves病患者的疗效,分析影响疗效的因素以及甲减发生情况。方法: 回顾性分析2011年1月至2012年3月在我院行¹³¹I 治疗并成功随访的398例Graves病患者。结果: 观察对象总治愈率达 46.7%,总有效率 86.7%;其中首次治愈率 48.6%,有效率为 87.3%; 治疗后1~3个月多数患者血FT3 、FT4 水平开始不同程度下降; 对治愈率分别进行单因素、多因素logistic回归分析表明甲状腺质量、24 h摄碘率、¹³¹I给药剂量、治疗次数及是否合并肝损是影响治愈的主要因素,甲状腺质量小者、24 h 摄碘率低者治愈率高,根据公式计算出给药剂量少者治愈率也高。对甲减发生的单因素分析表明,摄碘率低者甲减发生率较高(χ²=7.487,P=0.02367);而多因素回归分析表明性别、甲状腺质量、治疗次数是甲减发生的影响因素,女性、甲状腺质量小、首次治疗更易发生甲减(P均＜0.05)。结论: ¹³¹I 治疗Graves病疗效较好,可作为治疗首选,但其疗效受多种因素影响, 需根据具体情况决定给药量。     

Analysis from a year of increased cases of Acanthamoeba Keratitis in a large teaching hospital in the UK

Purpose of the studyTo report an observational study of Acanthamoeba Keratitis (AK) in University Hospital Coventry & Warwickshire (UHCW), Coventry, UK and determine risk factors, outcomes as well as incidence rates.MethodsA retrospective analysis was done of consecutive patients who were treated for AK by the corneal service at UHCW from January 2017 to January 2018. Cases were identified from 2 sources; the department of microbiology and the hospital pharmacy. Patient data was collected by 3 of the authors using both paper and electronic medical records. Information was also gathered over the telephone using a predefined questionnaire. The primary endpoint used for assessing duration of disease was time to resolution after the initial diagnosis.Results9 eyes were identified over the 12-month period, a drastic increase from previous years. All were contact lens (CL) wearers and 3 used daily disposable CL’s. 8 out of 9 patients had an improvement in best corrected visual acuity (BCVA) which was consistent with their baseline levels pre-infection. The average length of treatment was 107.25 days for the 8 resolved cases. 1 case is still having ongoing treatment. No case has required surgical treatment. Several patients admitted to exposing their CL to unsterile water either via swimming, showering or tap water. All patients had purchased their lenses from contact lens practitioners.ConclusionOverall, our study shows excellent outcomes. Almost all patients had resolution of symptoms with medical treatment and an improvement in visual acuity. Several contributing factors have aided us in achieving this including early diagnosis, a robust treatment protocol and diagnostic modalities such as Polymer Chain Reaction (PCR) and Confocal Microscopy (CFM). However, the increased incidence compared to previous years is a worrying trend and there will be an ongoing analysis looking at patterns of incidence in the future.     

一种便携式半导体激光PDT控制系统

设计研制了与第2代光敏剂相配用的半导体激光光动力治疗（PDT）控制系统，该系统采用掌上电脑（PDA），用VC6.0编程，通过PDA并口控制恒流源及制冷电路来驱动半导体激光器。结果表明，系统接入半导体激光器，控制系统工作正常；系统受干扰影响较小，工作稳定，具有便携、经济、精度高和效率高等特点。