Learning more about those who play in session: The National Play Therapy in Counseling Practices Project (Phase I).

Through a joint research committee sponsored by the Association for Play Therapy (APT) and the American Counseling Association (ACA), The National Play Therapy in Counseling Practices Project conducted the first phase of investigation. Findings offered a snapshot of mental health providers of play therapy, regarding the nature of who they are and what they do. In terms of training, play modalities, theoretical orientation, and employment setting, comparisons were made based on membership of participants in ACA or APT. Further research was suggested to examine the effectiveness of play therapy with specific therapeutic issues. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

一种神经康复机器人的研制

介绍了一种神经康复机器人,阐述了机器人的详细结构、工作原理、使用方法以及在结构上和控制模式上为 了保证患者瘫肢的安全所采取的策略。通过健康人实验证实了该机器人能够满足神经损伤患者康复训练的一般要 求,有望用于患者的临床康复训练。     

Recent progress in NIR-Ⅱ emitting lanthanide-based nanoparticles and their biological applications

The second near-infrared(NIR-Ⅱ,1000-1700 nm) window provides a superior optical platform with high resolution,deep penetration and high signal-to-noise ratios(SNRs),which results from the intrinsic low scattering and auto fluorescence in biological tissues.As one of the promising NIR-Ⅱ emitting probes,lanthanide based nanoparticles(LnNPs) exhibit high photo stability and chemostability,long photoluminescence lifetimes,low long-term cytotoxicity and narrow emission bandwidths.All these merits hav...     

Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus

Although ^99mTc is not an ideal Auger electron (AE) emitter for Targeted Radionuclide Therapy (TRT) due to its relatively low Auger electron yield, it can be considered a readily available “model” radionuclide useful to validate the design of new classes of AE-emitting radioconjugates. With this in mind, we performed a detailed study of the radiobiological effects and mechanisms of cell death induced by the dual-targeted radioconjugates ^99mTc-TPP-BBN and ^99mTc-AO-BBN (TPP = triphenylphosphonium; AO = acridine orange; BBN = bombesin derivative) in human prostate cancer PC3 cells. ^99mTc-TPP-BBN and ^99mTc-AO-BBN caused a remarkably high reduction of the survival of PC3 cells when compared with the single-targeted congener ^99mTc-BBN, leading to an augmented formation of γH2AX foci and micronuclei. ^99mTc-TPP-BBN also caused a reduction of the mtDNA copy number, although it enhanced the ATP production by PC3 cells. These differences can be attributed to the augmented uptake of ^99mTc-TPP-BBN in the mitochondria and enhanced uptake of ^99mTc-AO-BBN in the nucleus, allowing the irradiation of these radiosensitive organelles with the short path-length AEs emitted by ^99mTc. In particular, the results obtained for ^99mTc-TPP-BBN reinforce the relevance of targeting the mitochondria to promote stronger radiobiological effects by AE-emitting radioconjugates.     

放射性食管疾病的临床观察

采用临床病例分析方法探讨了胸部肿瘤放射治疗时引起的放射性食管损伤的临床特点、诊断和治疗措施。根据损伤反应出现的时间早晚,临床上将放射性食管损伤分为急性放射性食管损伤和慢性放射性食管损伤。急性放射性食管损伤在临床上最为多见,主要表现为吞咽困难、吞咽疼痛、胸骨后烧灼感。28例肺癌病人放射治疗后,急性放射性食管损伤发生率为18％,均为3级以下急性损伤,     

Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer

Breast cancer is the leading cause of cancer-related deaths for women in the United States and the rest of the world. About 8% of women develop breast cancer during the course of their lives. Dietary habits are closely associated with both the risk and progression of breast cancer. Dietary agents have accumulated increasing importance with regards to the prevention and treatment of breast cancer. One such manner by which these compounds can target breast cancer development and progression is through interference with the angiogenic pathways. Angiogenesis is an intricate process that involves the development of new capillaries from previously existing blood vessels. Disruption of this pathway, therefore, provides a novel and effective avenue for therapeutic intervention of breast cancer. Various phytochemicals found in the diet kill breast cancer cells in vitro and prevent as well as suppress breast cancer progression in various preclinical animal models. This review examines the value of dietary phytoconstituents in the prevention and treatment of breast cancer through modulation of the intricate and complex process of angiogenesis. In addition, the potential benefits, challenges, and future directions of research on anti-angiogenic dietary phytochemicals in the prevention and intervention of breast cancer are also addressed.     

Combine operations research with molecular biology to stretch pharmacogenomics and personalized medicine—A case study on HIV/AIDS

The dramatic reduction in morbidity and mortality associated with the use of highly active antiretroviral therapy has created new challenges for clinicians: AIDS has become a chronic, potentially life-threatening, condition in many clinical instances. In this paper, a novel system engineering approach based on mixed-integer linear programming (MILP) is presented to support HIV/AIDS clinicians when formulating real-world therapeutic plans for heavily treatment-experienced patients under variable settings. Our results suggest that, while current practices (standard protocols and/or subjective recommendations based on the clinician's experience) can generally provide satisfactory management of drug resistance in the short-term, optimization-based therapy planning has a far greater potential to achieve this goal over expanded time horizons thereby changing paradigms and rethinking best practices in the HIV/AIDS clinical arena. Moreover, the ability of this methodology to address other viral pathologies (e.g., hepatitis B and C virus) can make this work appeal to a broader audience.     

硼替佐米治疗复发难治性套细胞淋巴瘤的研究进展

复发难治性套细胞淋巴瘤(MCL)的治疗是临床医师面临的严峻挑战.近年来,蛋白酶体抑制剂硼替佐米的应用给复发难治性MCL患者的治疗提供了新方法.就硼替佐米治疗复发难治性MCL的机制、临床疗效以及MCL细胞对硼替佐米耐药产生的机制和应对策略进行综述.     

急性心肌梗死患者自体骨髓干细胞移植治疗效果随访

目的: 研究急性心肌梗死(Acute myocardial infarction,AMI)患者自体骨髓间质干细胞(Mesenchymal stem cells,MSCs)冠脉内注射治疗的安全性以及对心功能的改善作用,并探讨其可能机制。方法: 20例急性心肌梗死患者(治疗组)经皮冠状动脉介入(PCI)术后抽取骨髓分离、培养、扩增后12~14 d 行冠脉内注射,另选取20例PCI术后拒绝行细胞治疗的急性心肌梗死患者作为对照组,PCI术后1周及1年进行临床随访、超声心动图及¹⁸氟-脱氧葡萄糖单光子心肌断层显像(¹⁸F-FDG-SPECT)。结果: 治疗组未见与移植有关的体温升高及恶性心律失常发生。与对照组比较,1年后治疗组超声心动图心脏收缩、舒张功能指标及SPECT代谢缺损指标有明显改善,差异具有统计学意义(P<0.05)。结论: 急性心肌梗死患者自体骨髓间质干细胞冠脉内注射安全有效,可以改善患者心功能及远期预后;骨髓来源的心肌细胞生成及血管新生可能为其机制。