Toxicoproteomics and its application to human health risk assessment

Toxicoproteomics is the use of proteomic technologies to better understand environmental and genetic factors, toxic mechanisms, and modes of action in response to acute exposure to toxicants and in the long-term development of diseases caused or influenced by these exposures. Use of toxicoproteomic technologies to identify key biochemical pathways, mechanisms, and biomarkers of exposure and toxicity will decrease the uncertainties that are associated with human health risk assessments. This review provides an overview of toxicoproteomics from human health risk assessment perspectives. Key toxicoproteomic technologies such as 2-D gel-based proteomic methods and toxicoproteomic approaches are described, and examples of applications of these technologies and methodologies in the risk assessment context are presented. The discussion includes a focus on challenges and future directions.     

计算机维修模拟训练系统的设计与实现

探索了一种在多媒体环境下进行计算机及外部设备维修教学、训练的新方法 ,介绍了计算机维修模拟训练系统的设计与实现 ,给出了主要的设计思想、总体结构及关键技术。     

经管类专业应用型人才培养模式研究

民办高校应用型人才培养模式是民办高校为培养应用型人才而探索形成的一种可操作性的经验与理论架构。本文简单阐述了经管类专业应用型人才培养的意义,构建了经管类专业应用型人才培养方案,主要是构建以企业为依托的合作办学模式,构建＂两平台＋N模块＋一拓展＂课程体系,构建以学生为主体的教学方法和＂双师型＂师资队伍。     

农业类本科院校网络工程专业课程体系建设研究

我国网络工程专业毕业的学生人数已达相当规模,而在社会上的就业情况却未达到预期的目标,究其原因是学生在校所学课程与社会需求不匹配。本文就网络工程专业中应用型人才的需求,重点讨论专业方向、课程体系等方面的问题。     

境外公共安全防恐培训的几点思考

境外公共安全防恐培训能够强化员工对境外公共安全工作的认识,提高应对境外公共安全突发事件的能力;能够普及境外公共安全管理知识,增强员工境外工作期间的个人安全意识和防卫自救能力能够制定并落实境外公共安全管理责任及措施。汉油田职培中心境外公共安全防恐培训进行了严谨的培训需求调研和定位,教材开发和内容设计更趋完善,教学方法形式多样,课件制作引人入胜,防恐演习更具针对性和实用性。但在教师的亲身体验、培训内容的选取、教学团队的师资培养、防恐演习场地设施和人员的限制等方面还需要改进。     

Numerical evaluation of the effects of friction and geometric nonlinearities on the energy release rate in three- and four-point bend end-notched flexure tests

Nonlinear finite element analyses are used to examine the effects of friction and geometric nonlinearities on the energy release rate in three- and four-point bend end-notched flexure tests. Energy release rates are first determined by a recently developed direct energy balance approach. It is shown that the finite diameter loading rollers that are typically used in practical test set-ups cause both tests to be inherently nonlinear. The effect of these nonlinearities on the energy release rate is shown to be larger in the four point than the three point test and to increase with increasing roller diameter, increasing coefficient of friction along the crack plane, and decreasing supporting span length. For the four point test, the effect of these nonlinearities is also shown to increase with increasing ratio of inner to outer span length. Next, energy release rates at the onset of crack advance are determined by a simulated compliance calibration technique. This “perceived toughness” is compared with predictions of the “true toughness” given by the direct energy balance approach at the same load. It is shown that perceived toughnesses from this simulated compliance calibration procedure are larger than previously reported results that were obtained in a similar fashion using linear theory. In addition, the perceived toughness is shown to strongly depend upon the range used for fitting the load versus deflection data to obtain compliance. These findings are used to make some general recommendations regarding use of the two test methods and their associated data reduction techniques.     

Sliding mode control for two-time scale systems: stability issues

The paper presents some results on global exponential stability of linear time invariant systems with different time scales. The full system is decomposed in two reduced ones by means of singular perturbations and a smooth approximation of a Variable Structure Control is synthesized for each of them using Reaching Law approach. The global closed loop stability is then proved for the whole system using Lyapunov methods and a particular state space decomposition. Moreover a literal form for ε∗ (a parameter which measures the minimum separation between time scales) is derived.     

ATM网上的LAN仍真

对作为计算机网络未来发展方向的ATM网如何仿真以太网和令牌环方案作了详细的描述。此方案的优势在于它允许现有的LAN应用在不作任何修改的情况下，便可在ATM网上运行。     

论现代纺织业所需的人才资源开发

我国纺织工业的发展需要大批纺织人才。采用专家访谈、问卷调查等方式，分析了目前我国纺织业所需人才资源的知识结构状况，提出了纺织业应通过各种渠道培养适应纺织业发展的纺织复合型人才的观点。     

重力固体潮IMF的AM-FM模型及其非线性拟合

首先建立AM-FM数学模型,用多个相近载波的调幅信号组合描述它。利用最小二乘法对幅度调制和频率调制两个部分分别进行非线性拟合;拟合以相关系数满足一定条件为精度控制原则,拟合项数以相邻相关系数不再显著变化为判定条件。有效性检验证明该方法切实可行。重力固体潮IMF的拟合结果表明,AM-FM数学模型可以很好地刻画重力固体潮IMF;重力固体潮是多个AM-FM信号合成的复合信号。为后续深入研究重力固体潮的AM-FM信号特征、循环平稳信号特征等性质建立了良好的数学基础。