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91.
92.
M. Akita M. Nakajima Y. Uematsu K. Tokaji T. Kojima 《Fatigue & Fracture of Engineering Materials & Structures》2014,37(11):1223-1231
This paper describes the fatigue properties of the beta titanium alloy 55Ti–30Nb–10Ta–5Zr, generally referred to as ‘Gum Metal’. Rotating bending fatigue tests have been performed in laboratory air and in a 3% NaCl aqueous solution. The results obtained were compared with those of a conventional beta titanium alloy, Ti–22V–4Al. In tensile tests, 55Ti–30Nb–10Ta–5Zr indicated elasticity and microplasticity in the elastic region. Thus, the elastic modulus slightly decreased with an increasing strain, and the work hardening was minimal during plastic deformation. The mechanical properties of both of the alloys were comparable. The fatigue strength of 55Ti–30Nb–10Ta–5Zr in laboratory air was higher than that of Ti–22V–4Al, which could be attributed to the higher fatigue crack initiation resistance of 55Ti–30Nb–10Ta–5Zr than Ti–22V–4Al, while the resistance to small fatigue crack growth was similar. The fatigue strength of 55Ti–30Nb–10Ta–5Zr in laboratory air and in the 3% NaCl aqueous solution was analogous. In addition, corrosion pits were not observed in the run‐out specimen in the 3% NaCl aqueous solution, indicating a high resistance of 55Ti–30Nb–10Ta–5Zr against corrosion fatigue. 相似文献
93.
Liquid Crystal Enabled Early Stage Detection of Beta Amyloid Formation on Lipid Monolayers
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Monirosadat Sadati Aslin Izmitli Apik Julio C. Armas‐Perez Jose Martinez‐Gonzalez Juan P. Hernandez‐Ortiz Nicholas L. Abbott Juan J. de Pablo 《Advanced functional materials》2015,25(38):6050-6060
Liquid crystals (LCs) can serve as sensitive reporters of interfacial events, and this property has been used for sensing of synthetic or biological toxins. Here it is demonstrated that LCs can distinguish distinct molecular motifs and exhibit a specific response to beta‐sheet structures. That property is used to detect the formation of highly toxic protofibrils involved in neurodegenerative diseases, where it is crucial to develop methods that probe the early‐stage aggregation of amyloidogenic peptides in the vicinity of biological membranes. In the proposed method, the amyloid fibrils formed at the lipid–decorated LC interface can change the orientation of LCs and form elongated and branched structures that are amplified by the mesogenic medium; however, nonamyloidogenic peptides form ellipsoidal domains of tilted LCs. Moreover, a theoretical and computational analysis is used to reveal the underlying structure of the LC, thereby providing a detailed molecular‐level view of the interactions and mechanisms responsible for such motifs. The corresponding signatures can be detected at nanomolar concentrations of peptide by polarized light microscopy and much earlier than the ones that can be identified by fluorescence‐based techniques. As such, it offers the potential for early diagnoses of neurodegenerative diseases and for facile testing of inhibitors of amyloid formation. 相似文献
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95.
Ajay Arora Divya Choudhary Gaurav Agarwal Virender Pal Singh 《International Journal of Food Science & Technology》2008,43(11):1913-1921
Banana is one of the most important tropical fruits, and India ranks first in its world production. Banana cultivars rich in provitamin A carotenoids may offer a potential food source for alleviating vitamin A deficiency, particularly in developing countries. With a view to exploit banana peels as a source of valuable components, in the present study, proximate composition, carotenoids, beta‐carotene and some anti‐oxidative enzymes as well as carbohydrate content of selected Indian banana varieties were determined. Karpooravalli cultivar of banana showed the maximum accumulation of carotenoid content in the non‐edible (68 μg g?1 d.w.) portion of banana, while being the second highest in beta‐carotene content (143.12 μg per 100 g). However, Red Banana ranked highest in total carotenoid contents for pulp (4 μg g?1 d.w.) and beta‐carotene was estimated to be the highest in the case of peels (241.91 μg per 100 g) and in pulp (117.2 μg per 100 g). Karpooravalli cultivar of banana is also rich in carbohydrate content in terms of total starch (1786.0 μg g?1 d.w. in peels and 544.85 μg g?1 d.w. in pulp) and sugars (53.53 μg g?1 d.w. in peels and 39.05 μg g?1 d.w. in pulp). The catalase enzyme activity in these peels ranged from 5.66 to 35.57 nmol min?1 mg?1 proteins and was found at a higher level in cultivar Poovan, while the ascorbate peroxidase showed the range of 2.25 to 6.22 μmol min?1 mg?1 proteins. The peels of cultivars Red Banana and Karpooravalli are rich source of bioactive compounds, such as carotenoids (beta‐carotene), anti‐oxidative enzymes and carbohydrate contents. 相似文献
96.
Michaela K. Back Sonia Ruggieri Eric Jacobi Jakob von Engelhardt 《International journal of molecular sciences》2021,22(12)
Onset and progression of Alzheimer’s disease (AD) pathophysiology differs between brain regions. The neocortex, for example, is a brain region that is affected very early during AD. NMDA receptors (NMDARs) are involved in mediating amyloid beta (Aβ) toxicity. NMDAR expression, on the other hand, can be affected by Aβ. We tested whether the high vulnerability of neocortical neurons for Aβ-toxicity may result from specific NMDAR expression profiles or from a particular regulation of NMDAR expression by Aβ. Electrophysiological analyses suggested that pyramidal cells of 6-months-old wildtype mice express mostly GluN1/GluN2A NMDARs. While synaptic NMDAR-mediated currents are unaltered in 5xFAD mice, extrasynaptic NMDARs seem to contain GluN1/GluN2A and GluN1/GluN2A/GluN2B. We used conditional GluN1 and GluN2B knockout mice to investigate whether NMDARs contribute to Aβ-toxicity. Spine number was decreased in pyramidal cells of 5xFAD mice and increased in neurons with 3-week virus-mediated Aβ-overexpression. NMDARs were required for both Aβ-mediated changes in spine number and functional synapses. Thus, our study gives novel insights into the Aβ-mediated regulation of NMDAR expression and the role of NMDARs in Aβ pathophysiology in the somatosensory cortex. 相似文献
97.
There are two different pathways known to be used for the detoxification of hydrocyanic acid in insects, viz., rhodanese and beta" align="MIDDLE" BORDER="0">-cyano-l-ala-nine synthase. We consider the latter to be indicative for cyanogenesis, while rhodanese might, in general, play a more important role in sulfur transfer for protein synthesis. This paper reports on the distribution of beta" align="MIDDLE" BORDER="0">-cyano-l-alanine (BCA) in the Lepidoptera. First reports of cyanogenesis are presented for the following families: Papilionidae, Pieridae, Lycaenidae, Hesperiidae, Lymantriidae, Arctiidae, Notodontidae, Megalopygidae, Limacodidae, Cymatophoridae, Noctuidae, Geometridae, and Yponomeutidae. New and old records for three other families, the Nymphalidae, Zygaenidae, and Heterogynidae, are included to complete the present state of knowledge. Special emphasis has been laid on the Nymphalidae, where BCA has been detected in eight subfamilies. Taxonomic, geographic, and seasonal variation has been found in a number of cases. In all cases observed so far, the source of cyanogenesis in the Lepidoptera is most probably the cyanoglucosides linamarin and lotaustralin, although cyanogenesis based on mustard oil glucosides and cyclopentenoid glucosides might occur as well. BCA has been found in both cryptic and aposematic species, including taxa such as the Pieridae, Danainae, Ithomiinae, and Arctiidae, where the defensive biology is believed to be linked with other compounds, like mustard oil glucosides, cardenolides, or pyrrolizidine alkaloids. The ecological interaction and significance of such secondary compounds is not yet understood. 相似文献
98.
高放废液处理过程中总β放射性活度的分析 总被引:2,自引:0,他引:2
研究了高放废液处理过程中总β-放射性活度的分析方法。用液体闪烁计数法甄别α和γ射线的干扰,测量水相和有机相总β放射性的计数率。把β放射性核素分成4组,用液闪仪和Ge(Li)γ谱仪分析各组样品和各种淬灭条件下的等效效率的权重因子,通过效率等效法计算得到样品的总β放射性活度。分析了TRPO处理生产堆高放废液流程中各液液流的总β放射性活度。总β测量的不确定度小于5%。 相似文献
99.
100.
Steven C. Peterson 《Journal of chemical ecology》1988,14(3):815-824
Chemical trail marking and following by gregarious caterpillars,Malacosoma neustria L. (Lepidoptera: Lasiocampidae), was studied in the laboratory. As in other species ofMalacosoma, larvae deposit a trail pheromone from a sternal secretory site when searching the host for food. Larvae in the vanguard of foraging columns establish chemical trails as they explore new territory. Marking behavior diminishes as successive unfed foragers utilize the trail. These exploratory trails are subsequently overmarked by fed larvae returning to the tent. Other foragers follow the trails of fed larvae in preference to trails of unfed larvae. Thus, like the eastern tent caterpillar,M. americanum, successful foragers ofM. neustria recruit colony-mates to feeding sites. The chemical activity of both recruitment and exploratory trails degrades slowly, suggesting that the trail pheromone ofM. neustria is a nonvolatile substance. Caterpillars ofM. neustria readily follow the nonvolatile trail pheromone which has been identified fromM. americanum, 5beta" align="MIDDLE" BORDER="0">-cholestane-3,24-dione. 相似文献