一种基于身份的群签名方案*

群签名使得群中任何一个成员均可以代表该群进行签名,而不会暴露签名者的身份.当争议发生时,签名者的身份可以通过群管理员公开.基于身份的签名与群签名有许多相似性,给出了一个由基于身份的签名转换而来的群签名,并给出了它在电子选举中的应用实例.     

Design,Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents

To systematically evaluate the impact of neoglycosylation upon the anticancer activities and selectivity of steroids, four series of neoglycosides of diosgenin, pregnenolone, dehydroepiandrosterone and estrone were designed and synthesized according to the neoglycosylation approach. The structures of all the products were elucidated by NMR analysis, and the stereochemistry of C20-MeON-pregnenolone was confirmed by crystal X-ray diffraction. The compounds′ cytotoxicity on five human cancer cell lines was evaluated using a Cell Counting Kit-8 assay, and structure–activity relationships (SAR) are discussed. 2-deoxy-d -glucoside 5 k displayed the most potent antiproliferative activities against HepG2 cells with an IC₅₀ value of 1.5 μM. Further pharmacological experiments on compound 5 k on HepG2 cells revealed that it could cause morphological changes and cell-cycle arrest at the G0/G1 phase and then induced the apoptosis, which might be associated with the enhanced expression of high-mobility group Box 1 (HMGB1). Taken together, these findings prove that the neoglycosylation of steroids could be a promising strategy for the discovery of potential antiproliferative agents.     

Clinical Significance of Tumor Infiltrating Lymphocytes in Association with Hormone Receptor Expression Patterns in Epithelial Ovarian Cancer

Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes in tumors. Specifically, the presence of specific tumor-infiltrating lymphocytes (TILs) with particular hormone receptor expression is reportedly associated with breast cancer, however, this has not been revealed in epithelial ovarian cancer (EOC). Therefore, we investigated the association between hormone receptor expression and TILs in EOC. Here we found that ERα, AR, and GR expression increased in EOC, while PR was significantly reduced and ERβ expression showed a reduced trend compared to normal epithelium. Cluster analysis indicated poor disease-free survival (DFS) in AR+/GR+/PR+ subgroup (triple dominant group); while the Cox proportional-hazards model highlighted the triple dominant group as an independent prognostic factor for DFS. In addition, significant upregulation of FoxP3+ TILs, PD-1, and PD-L1 was observed in the triple dominant group compared to other groups. NanoString analyses further suggested that tumor necrosis factor (TNF) and/or NF-κB signaling pathways were activated with significant upregulation of RELA, MAP3K5, TNFAIP3, BCL2L1, RIPK1, TRAF2, PARP1, and AKT1 in the triple dominant EOC group. The triple dominant subgroup correlates with poor prognosis in EOC. Moreover, the TNF and/or NF-κB signaling pathways may be responsible for hormone-mediated inhibition of the immune microenvironment.     

解析参数对活性焦再生过程及再生效果的影响

 活性焦的热解析参数对再生活性焦的脱硫脱硝性能和机械强度至关重要。为了明确解析参数对活性焦再生过程和再生效果的影响规律,通过热解析试验探究活性焦硫残余比例、CO₂和CO生成量及再生活性焦脱硫脱硝性能随解析温度和解析时间的变化规律,继而明确适宜的活性焦热解析参数。结果表明,活性焦升温解析过程中,脱硫产物在317 ℃左右迅速分解,随后分解速率下降;在进入恒温解析阶段后脱硫产物分解速率先快速下降,而后进入缓慢解析状态。硫残余比例随恒温解析温度的升高而下降,在530 ℃下解析3 h可使脱硫产物完全解析;解析温度高于430 ℃后,活性焦表面的酚基、醌基、内酯基等含氧官能团分解量明显增加,并随恒温解析温度的升高而持续增加,分解所生成的CO和CO₂也随之大幅增加,这将使活性焦的孔隙结构进一步发展,继而不利于活性焦机械强度的保持;解析温度低于530 ℃时,硫残余比例随解析温度的升高而持续降低,使再生活性焦的脱硫脱硝性能持续提高;解析温度高于530 ℃后,含氧官能团分解量随解析温度的升高而持续增加,这将有利于提高活性焦表面SO₂氧化反应速率,继而使再生活性焦的脱硫性能持续升高,但酚基、内酯基等酸性含氧官能团的分解使再生活性焦对NH₃的吸附性能降低,进而使其脱硝性能降低。在兼顾再生活性焦脱硫脱硝性能、机械强度和生产效率等多方面因素时,430 ℃恒温解析3 h是相对较优的解析参数。在此解析条件下,再生活性焦的硫残余比例仅为1.8%,含氧官能团尚未发生大量分解,脱硫脱硝性能相对较为优良。     

数据融合在电梯群控系统中的应用

将数据融合技术引入电梯群控系统中,建立了基于数据融合技术的模糊联结聚合神经网络模型,对影响电梯调度的各因素进行充分有效的数据处理后,得到的电梯控制参数作为电梯调度单元的输入.应用实例表明了该方法是方便且有效的.     

Ti-25V-15Cr-2Al-2Mo-0.2C阻燃β钛合金的蠕变变形结构研究

采用TEM技术研究了具有不同热处理组织的Ti-25V-15Cr-2A1-2Mo-0．2C合金存在540℃，250MPa，100h蠕变作用后的变形结构。结果表明：位错环组是合金蠕变变形结构中的典型位错组态；合金的蠕变抗力随β基本上弥散分布的第二相析出数量的增加而提高。添加微量能提高蠕变抗力的合金元素，如Si元素等，是改善合金蠕变性能的可行途径。     

巯基活性炭分离富集发射光谱法同时测定金、铂、钯和铊

研究了巯基活性炭在盐酸介质中对金、铂、钯和铊的吸附能力。该法具有吸附速度快、吸附容量大、在一定条件下，普通金属不被吸附的特点，可用于分离富集各类矿物中微量贵金属。吸附后巯基活性炭低温灰化，与缓冲剂混合发射光谱法同时测定金、铂、钯和铊，选择锆作内标线，直接压样于杯形的石墨电极中，该方法简便、快速、准确。对测定条件、干扰因素进行了研究，从而建立测定金、铂、钯和铊的新方法。金、铂、钯和铊的分析线分别为312.3nm，306．5nm，311．4nm和313．1nm，内标线选择为310．7nm的锆，金、铂、钯和铊的线性范围(原子百分数)分别为0～0．20％，0～0．40％，0～0．20％和0～0．40％。金、铂、钯和铊的检测限分别0．01％，0．003％，0．003％和0．001％。用于样品的测定获得满意结果。     

惰性配合物在铂族金属分离和测定中的应用

介绍了铂族金属在形成各种配合物时不同的动力学性质，评述惰性配合物在铂族金属分离和测定中的应用。     

影响PET树脂反应活性因素的分析

探讨了影响连续固相增粘产品活性的因素，提出了控制主反应器的温度、氮气流量、基础切片的端羧基、氮气露点等主要因素，实现生产的平稳控制，从而保证产品黏度的稳定。     

中国石化集团原油资源优化配置及建议

介绍了石化集团原油资源现状，分析了原油资源配置过程中存在的主要问题，提出了资源优化配置的原则与基本思路，及实施原油资源优化配置的配套措施和建议。