基于Ansys Workbench的齿轮副有限元分析

摆线针轮减速器作为重要的机械传动部件具有体积小、重量轻、传动效率高、传动比大、承载能力强和使用寿命长等优点,广泛应用于现代工业诸多领域中。本文针对变桨减速器技术要求,通过典型摆线针轮减速器的传动原理及结构特点分析,建立齿轮、摆线轮等关键零部件的计算模型,并进行静力学有限元分析,其中对代表性的齿轮副进行了有限元模型的建立,并在Ansys Workbench中进行分析,包括一对外啮合齿轮副、摆线轮与针齿接触副,最后将有限元分析结果与解析法结果相比较。     

针梳机梳箱动静力学有限元分析研究

利用ANSYS软件对针梳机梳箱进行了模态分析,给出了梳箱主振型和固有频率;对梳箱进行静力学分析,给出了梳箱在工作过程中的最大应力,为针梳机设计和改进提供了充分依据。     

2-RRR+RRS球面并联机构超静定力学全解

针对2-RRR+RRS球面并联机构,利用拆杆法建立其4次超静定的静力学平衡方程;考虑构件弹性,利用小变形叠加原理,建立机构的4个变形协调方程。基于所建方程,利用MAPLE软件分析求得在不同输入力和力矩情况下,机构构件所受力与机构位姿关系曲线图,明晰了不同外力或外力矩输入情况下对机构影响的差异。研究结果为该机构的工程设计及实际应用提供了静力学理论基础和依据。     

中美科幻电影数量比较及对我国科幻电影发展的几点思考

科学离不开想象力,科幻电影在一定程度上是对一国当前科研能力和制作技能的一种折射。通过对比中美两国的科幻电影数量(1995─2008),结合对科幻电影史案例的考察,引出对科幻电影的科普功能以及我国科幻电影发展的几点思考。     

基于信息熵的河北省用水结构时空演变分析

为了揭示河北省用水结构在时间和空间上的演变规律,采用信息熵理论分析河北省及各地市2001-2018年的用水结构时空变化规律。结果表明：2001-2018年河北省各地市用水结构信息熵值由0.68上升至1.00,反映出各地市用水系统的稳定性和均衡性在不断增强;时间尺度上,各地市信息熵值分为“高、中、低”3个梯队,梯队之间的差异呈现逐渐扩大的演变趋势,2018年各梯队信息熵值的差异均在0.12以上;空间尺度上,全省信息熵值由环渤海地区向内陆、环京津地区向冀南地区均呈现逐渐减小的渐变型分布规律。上述时空演变特征反映了河北省的经济社会发展历程对用水结构变化的映射作用。研究成果可为河北省各地市未来产业优化布局和用水管理提供科学决策依据。     

Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions

A colorectal adenoma, an aberrantly growing tissue, arises from the intestinal epithelium and is considered as precursor of colorectal cancer (CRC). In this study, we investigated structural and numerical chromosomal aberrations in adenomas, hypothesizing that chromosomal instability (CIN) occurs early in adenomas. We applied array comparative genomic hybridization (aCGH) to fresh frozen colorectal adenomas and their adjacent mucosa from 16 patients who underwent colonoscopy examination. In our study, histologically similar colorectal adenomas showed wide variability in chromosomal instability. Based on the obtained results, we further stratified patients into four distinct groups. The first group showed the gain of MALAT1 and TALAM1, long non-coding RNAs (lncRNAs). The second group involved patients with numerous microdeletions. The third group consisted of patients with a disrupted karyotype. The fourth group of patients did not show any CIN in adenomas. Overall, we identified frequent losses in genes, such as TSC2, COL1A1, NOTCH1, MIR4673, and GNAS, and gene gain containing MALAT1 and TALAM1. Since long non-coding RNA MALAT1 is associated with cancer cell metastasis and migration, its gene amplification represents an important event for adenoma development.     

复合防护液舱抗爆效能对比试验研究

液舱是舰船多层防护结构体系中的重要功能舱室,战斗部近距离爆炸时,高速破片和冲击波载荷将对防护液舱产生严重的毁伤效应。针对高速破片和冲击波作用下防护液舱的动态响应特性和毁伤模式,提出了复合防护液舱的结构形式。为了对比该液舱相对常规液舱的抗爆效能,开展了战斗部模型近距离爆炸载荷作用下复合液舱和常规结构形式液舱毁伤的模型试验,得到了战斗部模型破片速度、液舱结构的变形、应变、破口尺寸、舱壁压力等参量。通过对比发现,相对于传统液舱结构,复合防护液舱前面板、后面板最大变形分别减少22.78%和8.47%,结构应变降低30%,冲击波峰值减弱18.62%,该新型结构形式明显提高了液舱抗爆防御效果。     

关于飞行力学的再思考

对多年来国内外有关飞行力学的发展过程、研究范畴、分类，以及问题表述方式等重新进行了一些考察和思考．从学术和实践的观点，对飞行力学的体系结构和问题表述方式等进行了讨论，并提出了个人的一些看法和建议．     

水样中氨氮测定方法研究

对各种氨氮的测定方法进行分析,总结各种方法的优缺点,以方便测量人员针对不同的水体环境,选择合适的方法对氨氮的量进行测定,这对减轻分析者的劳动强度,具有积极的现实意义。     

One Question,Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists

Fragment‐based lead discovery is gaining momentum in drug development. Typically, a hierarchical cascade of several screening techniques is consulted to identify fragment hits which are then analyzed by crystallography. Because crystal structures with bound fragments are essential for the subsequent hit‐to‐lead‐to‐drug optimization, the screening process should distinguish reliably between binders and non‐binders. We therefore investigated whether different screening methods would reveal similar collections of putative binders. First we used a biochemical assay to identify fragments that bind to endothiapepsin, a surrogate for disease‐relevant aspartic proteases. In a comprehensive screening approach, we then evaluated our 361‐entry library by using a reporter‐displacement assay, saturation‐transfer difference NMR, native mass spectrometry, thermophoresis, and a thermal shift assay. While the combined results of these screening methods retrieve 10 of the 11 crystal structures originally predicted by the biochemical assay, the mutual overlap of individual hit lists is surprisingly low, highlighting that each technique operates on different biophysical principles and conditions.