“六化一落实”管理模式在友众矿的应用

友众煤矿针对企业员工素质参差不齐、地质条件日趋复杂的现状,提出并应用了“六化一落实”安全管理模式。通过应用该安全管理模式,友众矿安全生产管控水平和保障能力得到显著提升,杜绝了事故的发生,实现了安全生产。     

"两软一硬"不稳定煤层工作面覆岩"两带"发育高度研究

为探索禹州煤田西南部云盖山煤矿二矿软煤、软底和硬顶(简称“两软一硬”)及开采煤层厚度变化较大的不稳定煤层顶板垮落带和导水断裂带发育高度,采用现场钻孔成像技术、经验公式类比分析和数值模拟综合研究方法,对该矿23301采煤工作面顶板覆岩垮落带、导水断裂带高度进行了分析,获得了工作面在非充分采动垮落和充分采动垮落条件下“两带”高度量化取值,垮落带最大高度为14.4 m,导水断裂带最大高度为50.0 m,认为现场钻孔成像技术可用于采动覆岩“两带”发育高度的计算。研究结果对研究区预采掘顶板水害防治及顶板支护具有较重要的参考价值。     

Phase equilibria in the Fe-V-O system near “FeO”-V2O3 isopleth

Phase equilibria in the “FeO”-V₂O₃ system from 1273 to 1808 K and in the range of oxygen partial pressure from 10⁻¹⁵ to 10⁻⁴ atm are investigated. High-temperature quenching, XRD, SEM-EDS, and DSC are used to determine the phase relations. Stable regions of (FeO)_s.s., (V₂O₃)_s.s., and spinel phases are considerably effected by the oxygen partial pressure, and structural models are proposed as (Fe²⁺, Fe³⁺, V²⁺)_1-xO, (V²⁺, V³⁺, V⁴⁺, Fe³⁺)₂O_3+x, and (Fe²⁺, Fe³⁺, V³⁺)(Fe²⁺, Fe³⁺, V³⁺, Va)₂O₄. Continuous solid solution FeV₂O₄-Fe₃O₄ is formed. The nonstoichiometry of FeV₂O₄ is attributed to the appearance of vanadium vacancies for electroneutrality due to the oxidation of Fe²⁺. The standard Gibbs energy of formation for FeV₂O₄ and component activities in FeV₂O₄-Fe₃O₄ solid solution at 1623 and 1773 K are derived based on the equilibrium oxygen partial pressure. The cation distribution in FeV₂O₄ at different temperatures is obtained according to site preference energy.     

On the analogy between the bias flow aperture theory and the Coriolis flowmeter “bubble theory”

Two different physical phenomena, described by the bias flow aperture theory and the Coriolis flowmeter “bubble theory”, are compared. The bubble theory is simplified and analogies with the bias flow aperture theory are appraised.     

大数据商业模式的现状与挑战

论述了在我国“互联网+”战略中大数据的时代价值,在回顾大数据前2个阶段商业模式的基础上,分析了在工业互联网时代大数据商业模式面临的新挑战。     

Hydration-Induced β-Sheet Crosslinking of α-Helical-Rich Spider Prey-Wrapping Silk

Due to its moderate strength (≈700 MPa) and impressive extensibility before breaking (≈60–80%), orb-weaving spider aciniform (AC) prey-wrapping silks are actually the toughest of the spider silks but are remarkably understudied. The previous results indicate that native AC silk fibers are an α-helix rich coiled-coil/β-sheet hybrid nanofiber, and that conversion of disordered or helical domains to β-sheet aggregates is surprisingly minimal and overall β-sheet content is low (≈15%). In this work, it is demonstrated through scanning electron microscopy that native AC silk fibers undergo matted cross-linking upon exposure to moisture that increases silk stiffness. The unique molecular mechanism of water-induced cross-linking is revealed with solid-state NMR (SSNMR) methods; water-induced morphological changes are correlated with an increase in AC silk protein β-sheet content, and additionally a minor unfolding of coiled-coil regions is observed. Continued and increased β-sheet cross-linking is observed upon application of mechanical shear. The size of these β-sheet domains to be 4–6 nm using Wide-Line Separation SSNMR is determined. The observation that merely water treatment can be used to convert a protein-based material from a flexible/extensible α-helix-rich fiber to a rigid crossed-linked β-sheet mat is a novel observation that should provide new avenues in bioinspired materials design.     

A Nano “Immune-Guide” Recruiting Lymphocytes and Modulating the Ratio of Macrophages from Different Origins to Enhance Cancer Immunotherapy

Artificially modulating the type, density, and location of immune cells within the tumor microenvironment can suppress tumor growth and efficiently promote current immunotherapy. In this study, a magnetite nanoparticle-based “immune-guide” is developed by the functionalization of magnetite nanoparticles with hyaluronic acid (HA). HA, an extracellular matrix component, can target various CD44-overexpressing tumors and mediate the adhesion and migration of multiple types of immune cells. Thus, HA-functionalized magnetite nanoparticles (HA-PDA@Fe₃O₄) can highly efficiently accumulate in breast cancer and penetrate deep into the tumor parenchyma. Consequently, high intratumoral concentration of HA, serving as a “guidepost,” can directly recruit lymphocytes and elicit more chemokine production through cascading amplification effects, turning the immune “cold” tumor into a “hot” one. More importantly, HA-PDA@Fe₃O₄ can effectively remodel the diversity, origin, and activation of tumor-associated macrophages by recruiting and activating infiltrating macrophages, while simultaneously reducing the M2-maintained tissue-resident macrophages. Thus, HA-PDA@Fe₃O₄ synergistically improves T cell- and macrophage-based immunotherapies as well as interferes with the formation of premetastatic niches in the lung. By redistributing the localization of HA in tumors by using magnetite nanoparticles, this study provides a unique strategy to modulate the tumor immune microenvironment and potentiate tumor immunotherapies by using biocompatible nanomaterials without any therapeutic drug.     

关于现代工程项目进度管理的探讨

简述了几种国际上具有代表性的项目管理学科体系,引入"5+3"工程项目管理模式框架。从承包商的角度,探讨了基于"5+3"工程项目管理模式框架下,项目进度管理与控制的原理和方法,供同行借鉴和参考。     

The α-factor in the Taylor flow-stress law in monotonic,cyclic and quasi-stationary deformations: Dependence on slip mode,dislocation arrangement and density

The aim of the present work is to assess in a formal manner “effective” values of the geometrical factor α which takes into account the arrangement of the dislocation pattern in the classical Taylor flow-stress law. For this purpose, selected experimentally well-documented cases of unidirectional and cyclic plastic deformation were analyzed. It is shown that, in both monotonic and cyclic deformation, the α-factor depends on the mode of deformation (single slip versus multiple slip). For examples of dominant primary slip interaction, a value α ≈ 0.1 is found. However, more frequently, α ≈ 0.3–0.4, typical of forest interaction, obtains. As deformation proceeds, the dislocation pattern frequently becomes more heterogeneous (cell formation) and approaches a state of lower energy, with increasing lattice misorientations which arise from an increasing density of geometrically necessary dislocations (GNDs). In these cases, α is generally lowered, for example from an initial value of 0.35 down to values around 0.2. This behaviour is explicable in terms of the composite model in which the heterogeneity is explicitly taken into account. Very similar developments of the dislocation arrangement, accompanied by a decrease of the α-value, are also noted during so-called “steady-state” cyclic and high-temperature creep deformations. In both cases, deformation is shown to be only quasi-stationary due to the fact that well-documented small but non-negligible microstructural changes, associated with a mild increase of the density of the GNDs, persist during deformation. The overall behaviour is readily described in an empirical manner in a unified picture. From the results obtained follows the requirement for a more general flow-stress model which considers explicitly the interaction of different slip systems and the heterogeneity of the dislocation pattern.