Protein interaction networks: centrality,modularity, dynamics,and applications

In the post-genomic era, proteomics has achieved significant theoretical and practical advances with the development of high-throughput technologies. Especially the rapid accumulation of protein-protein interactions (PPIs) provides a foundation for constructing protein interaction networks (PINs), which can furnish a new perspective for understanding cellular organizations, processes, and functions at network level. In this paper, we present a comprehensive survey on three main characteristics of PINs: centrality, modularity, and dynamics. 1) Different centrality measures, which are used to calculate the importance of proteins, are summarized based on the structural characteristics of PINs or on the basis of its integrated biological information; 2) Different modularity definitions and various clustering algorithms for predicting protein complexes or identifying functional modules are introduced; 3) The dynamics of proteins, PPIs and sub-networks are discussed, respectively. Finally, the main applications of PINs in the complex diseases are reviewed, and the challenges and future research directions are also discussed.     

基于MRIO与SNA的中国水资源空间转移网络分析

基于2002年、2007年和2012年的多区域投入产出表的相关数据,利用多区域投入产出(MRIO)模型和社会网络分析法(SNA)分析了中国水资源流动网络的空间关联性和结构特征。结果表明:网络中的链接数量没有随水足迹贸易值的增加而增加,链接路径上的流量不断增加,网络的韧性不够,空间关联渠道有待拓展,存在一定的等级差异,稳定性需要加强;网络中一些省份链接的增加,会削弱其他省份的链接数目,这种可塑性特征有利于在全国范围内合理配置水资源;将网络划分为4个板块,板块间的溢出关系主要是以板块内部为主,且少数板块之间没有任何的溢出关系。     

Fuzzy adaptive networks in machining process modeling: surface roughness prediction for turning operations

Due to the complexity of the machine tool structure and the cutting process, the dynamics of machining processes are still not completely understood. This is especially true due to the demand of high-speed machining to increase productivity. In order to model and control these complex processes, new approaches, which can represent complex phenomenon combined with learning ability, are needed. The combined neural–fuzzy approach appears to be ideally suited for this purpose. In this paper, the recently developed fuzzy adaptive network (FAN) is used to model surface roughness in turning operations. The FAN network has both the learning ability of neural network and linguistic representation of complex, not well-understood, vague phenomenon. Furthermore, it can continuously improve the initially obtained rough model based on the daily operating data. To illustrate this approach, a model representing the influences of machining parameters on surface roughness is established and then the model is verified by the use of the results of pilot experiments. Finally, a comparison with the results based on statistical regression is provided.     

Modeling of tool wear in drilling by statistical analysis and artificial neural network

The useful life of a cutting tool and its operating conditions largely control the economics of the machining operations. Hence, it is imperative that the condition of the cutting tool, particularly some indication as to when it requires changing, to be monitored. The drilling operation is frequently used as a preliminary step for many operations like boring, reaming and tapping, however, the operation itself is complex and demanding.

Back propagation neural networks were used for detection of drill wear. The neural network consisted of three layers input, hidden and output. Drill size, feed, spindle speed, torque, machining time and thrust force are given as inputs to the ANN and the flank wear was estimated. Drilling experiments with 8 mm drill size were performed by changing the cutting speed and feed at two different levels. The number of neurons in the hidden layer were selected from 1, 2, 3, …, 20. The learning rate was selected as 0.01 and no smoothing factor was used. The estimated values of tool wear were obtained by statistical analysis and by various neural network structures. Comparative analysis has been done between statistical analysis, neural network structures and the actual values of tool wear obtained by experimentation.     

移动定位技术的现状与发展趋势

基于位置服务为人们的日常生活带来了极大的方便,同时也推动了移动定位技术行业的快速发展。针对移动定位技术发展状况,分析目前主流定位技术的优劣,并对取得的突破作简单的总结归纳。     

接收方预约信道的水声传感器网络MAC协议

为了获得更高的网络吞吐量,更低的端到端时延,设计出了一种适用于分簇网络的水声传感器网络MAC协议,该协议采用接收方建立握手机制,有效的获取邻居节点通信时的状态,动态分配发送时隙,实现数据包以报文序列方式无冲突的到达接收端.仿真结果表明,与同类MAC协议(FERI, RIPT)相比,该协议提高了网络吞吐量,降低了数据丢失率和端到端时延.     

一种面向空地一体化组网的体系架构

空间网络是空地一体化组网中地面网络延伸的重要组成部分。针对空间网络为移动星座的场景,传统的空地一体化组网模型将空间网络视为独立自治域,利用边界网关协议将空间网络与地面自治域互联起来,最大化同地面网络保持兼容。然而,传统组网模型存在边界网关面临频繁会话中断或大量路由更新等问题。通过重新审视空间网络的角色定位和边界划定问题,提出一种面向空地一体化组网的体系架构Slink。Slink的核心思想是空间网络为地面网络提供互联通道,利用星地网关隔离空地两网间的路由更新。实验仿真表明,Slink体系架构能够有效减小对空间路由器的路由存储空间需求,降低星地网络间的带宽消耗。     

Performance comparison of reduced models for leak detection in water distribution networks

This paper presents a methodology for comparing the performance of model-reduction strategies to be used with a diagnostic methodology for leak detection in water distribution networks. The goal is to find reduction strategies that are suitable for error-domain model falsification, a model based data interpretation methodology. Twelve reduction strategies are derived from five strategy categories. Categories differ according to the manner in which nodes are selected for deletion. A node is selected for deletion according to: (1) the diameter of the pipes; (2) the number of pipes linked to a node; (3) the angle of the pipes in the case of two-pipe nodes; (4) the distribution of the water demand; and, (5) a pair-wise combination of some categories.The methodology is illustrated using part of a real network. Performance is evaluated first by judging the equivalency of the reduced network with the initial network (before the application of any reduction procedure) and secondly, by assessing the compatibility with the diagnostic methodology. The results show that for each reduction strategy the equivalency of networks is verified. Computational time can be reduced to less than 20% of the non-reduced network in the best case. Results of diagnostic performance show that the performance decreases when using reduced networks. The reduction strategy with the best diagnostic performance is that based on the angle of two-pipe nodes, with an angle threshold of 165°. In addition, the sensitivity of the performance of the reduced networks to variation in leak intensity is evaluated. Results show that the reduction strategies where the number of nodes is significantly reduced are the most sensitive.Finally this paper describes a Pareto analysis that is used to select the reduction strategy that is a good compromise between reduction of computational time and performance of the diagnosis. In this context, the extension strategy is the most attractive.     

基于改进FAHP的电力通信网可靠性评估方法研究

论文阐述了可靠性的一般评估方法,在借鉴TMN管理模型的基础上,对电力通信网可靠性进行了分层,构建了可靠性综合评估指标体系.为减少指标体系权重的主观性,提高评估结果的客观性和可信性,提出了一种改进的FAHP综合可靠性评估方法.该方法基于对数最小二乘法(LLSM)进行模糊权重计算,利用限位系数法来实现评估结果的解模糊过程,实例评估验证了该方法的有效性和可行性.最后对电力通信网可靠性的研究方向给出了建议.