Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment

The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified using double solvents in the extraction of analytes. With the modified method, some of the previously undetectable metabolites were recovered and subtle differences in the metabolic changes upon exposure to a single dose of VPA between males and female rats were identified. In male rats, changes in 2-hydroxybutyric acid, pipecolic acid, tetratriacontane and stearic acid were found between the control and treatment groups at various time points from 2.5 h up to 24 h. In contrast, such differences were not observed in female rats, which could be caused by the vast inter-individual variations in metabolite levels within the female group. Based on the measured DBS drug concentrations, clearance and apparent volume of distribution of VPA were estimated and the values were found to be comparable to those estimated previously from full blood drug concentrations. The current study indicated that DBS is a powerful tool to monitor drug levels and metabolic changes in response to drug treatment.     

WT615增压CNG电喷发动机燃烧特性数值分析

以WT615 CNG发动机为模拟研究对象,采用KIVA-3V软件建立了多维软件计算模型,并验证了模型的准确性。在此基础上研究了主要结构参数——燃烧室形状对燃烧特性和整机性能的影响。研究表明,直口形燃烧室的动力性、经济性能最好,更加适用于该天然气发动机,但排放性能有待提高;缩口形燃烧室的整机性能次之,碗形燃烧室的动力性和经济性则较差,后燃现象严重,不适用于天然气发动机。     

华能玉环电厂1000 MW机组汽缸碰撞试验定位工艺

详细介绍了华能玉环电厂1 000MW机组采用碰撞试验的方法进行汽轮机高、中、低压缸轴向、径向定位。该方法区别于传统的K 值和汽封洼窝中心定位法, 在安全和准确性方面有独到之处。     

沿空掘巷小煤柱侧防瓦斯泄漏技术

针对赵庄煤业沿空掘巷存在的小煤柱侧瓦斯泄漏隐患,制定了"柔性薄喷+注浆"治理方案,采用柔性薄喷材料替代混凝土,喷涂厚度5 mm,有效解决了材料运输和开裂问题,采用高密度浅钻孔和快凝注浆材料,避免了浆液流入采空区。效果考察表明:柔性薄喷材料挂壁性和柔韧性良好,掘巷服务期间小煤柱侧未出现明显瓦斯泄漏。     

浅析带容器法兰中压储气罐的设计

本文介绍了中压储气罐的设计过程、设计参数的确定依据以及在设计过程中应注意的事项.     

Diagnosis of TIG welding based on ultraviolet radiation

Through collecting the radiation of tungsten inert gas (TIG) welding arc, the radiation distribution in ultraviolet zone is analyzed in order to study the variation rule of ultraviolet radiation versus welding condition. The explanation for the variation is also provided bused on spectral radiation theory of arc light. Furthermore, through analysis of disturbanee factors, the integral intensity signal of radiation in ultraviolet zone is applied for diagnosis of welding process. The spectral signal of ultraviolet radiation can reflect the disturbance factors and welding conditions, which can be used for online diagnosis of welding process.     

电加热器预热在水轮机转轮焊接中的应用

介绍了450t大型转轮焊接预热技术的改进措施,在保证转轮整体加热的基础上取得了良好的效果,节约了大量的材料及能源费用。     

焦作矿区煤层瓦斯合理预抽期的研究

主要介绍了合理预抽期确定模型在焦作矿区的应用。为了减少瓦斯突出的危险性,合理地确定预抽期是瓦斯抽放的关键因素之一。     

高瓦斯自燃煤层综放工作面瓦斯综合治理

通过对高瓦斯自燃煤层综采放顶煤回采工作面的瓦斯涌出考察,及对瓦斯涌出与风量、高抽巷布置、推进速度、周期来压的关系分析,提出瓦斯综合治理措施,在实践中取得较好成效。     

抽放方法治理采煤工作面上隅角瓦斯

针对高瓦斯工作面上隅角瓦斯大,严重影响安全,制约生产的问题,采用直接抽放工作面上隅角瓦斯及顶板抽放法取得成功。实践证明顶板抽放法是解决高瓦斯采面瓦斯问题非常有效和更为安全的方法。