染料废水处理技术现状与发展

采用十二烷基三甲基氯化铵对高炉矿渣进行改性,制备一种低成本、环境友好型的吸附剂来处理染料废水,研究分析了吸附剂剂量、吸附时间、染料初始浓度和pH值因素对改性矿渣吸附活性艳蓝KN-R能力的影响以及改性矿渣表征的变化规律。结果表明：当改性矿渣用量为10 g/L,染料初始浓度为60 mg/L,pH值为2,以及吸附120 min时,改性矿渣对污水的处理后可达到较大脱色率96%,而在初始浓度为150 mg/L时为较优溶度,该浓度下脱色率与吸附量均较高。通过XRD和FTIR实验对矿渣与改性矿渣的表征特点进行对比分析,分析表明十二烷基三甲基氯化铵可以有效地对矿渣进行改性,改性后的矿渣吸附能力得到了显著提升。     

煤炭精准开采地质保障技术的发展现状及展望

为研究含水率、粒径、温度等因素对煤样吸附瓦斯特性的影响,选取黄陵二号煤矿2^#煤层煤样,通过HCA型高压瓦斯吸附仪,采用正交实验法开展不同含水率、粒径、温度作用下煤样瓦斯等温吸附实验,得到了影响瓦斯吸附性能的主控因素。研究结果表明：不同含水率、粒径、温度条件下,煤的瓦斯吸附曲线均符合Langmuir理论;各因素对吸附常数a值的敏感性依次为粒径>温度>含水率,粒径影响程度是含水率的3.126倍、温度的4.458倍;各因素对吸附常数b值、吸附饱和度X值的敏感性依次为温度>粒径>含水率,温度对吸附常数b值的影响程度是粒径的3.946倍、含水率的7.719倍,温度对吸附饱和度X值的影响程度是含水率的4.947倍、粒径的1.918倍;煤样优先吸附水分,瓦斯吸附量随含水率的增大而减小;瓦斯吸附过程会放热,当温度升高时,瓦斯吸附量会减少;粒径减小,增大了煤样的比表面积,导致瓦斯吸附量增加。

     

钻孔机器人钻进工况智能感知与自适应控制机理研究

针对煤矿井下钻孔作业场景特点,分别选取了基于煤岩图像特征和基于钻进参数反馈的识别方法。为了提高煤岩界面识别准确性,对前述的2种识别方法采用深度学习模型实现了2种异构信息的耦合识别。耦合识别模型基于神经网络模型构建,以CNN卷积神经网络为基础,扩展得到深度残差神经网络模型,其结构主要由骨干网络、颈部网络、头部网络3个部分构成。通过数据库模型训练,得到最终识别方法。通过在煤矿井下进行现场钻孔试验,验证了识别方法的准确性,其中煤岩界面识别准确率达92%。

     

我国煤矿冲击地压防治现状与难题

为提高煤矿冲击地压监测预警水平,对国家能源集团新疆能源有限责任公司下属矿井冲击地压监测预警现状进行分析,提出多参量集成监测预警平台本地化建设方案。该平台基于B/S架构并采用工业互联网平台,包含应用服务平台、物联网平台、大数据平台、运维平台4个模块,具备监测预警一张图、实时监测、综合预警、报表系统、设备管理、语音报警等功能,且融合了冲击地压多系统多参量监测预警指标体系和多参量集成预警模型。平台本地化建设实现了数据信息的监测、挖掘、融合分析和可视化呈现,可进行微震、地音、应力等监测数据的深度研判和危险预警的智能发布,多参量集成预警模型大幅度提高了预警效率和效果,为矿山冲击地压灾害防控提供了决策依据。

     

地质钻探垂钻定向纠偏控制的工程实现与实验分析

理论提出的纠偏方法需反复进行实验验证方可应用于实际工程,然而垂钻纠偏控制过程复杂,操作难度大,所需时间长、资金庞大,直接将所提方法放置现场调试是不可取的,而仅采用计算机仿真对算法进行验证也有一定局限性,因此发展和研究纠偏控制工程实现方法十分必要。本文以地质钻探钻进过程定向纠偏控制的工程实现为导向,首先分析并给出实际纠偏工艺过程以及纠偏控制的特点与目标;然后总结基于模型预测控制的纠偏控制问题与优化目标,结合笔者早期的一些纠偏控制理论研究,分别阐述不同纠偏工况下的纠偏控制方法;其次开发定向纠偏控制系统,用于集成纠偏控制算法,使得算法能够应用于实际工程;最后设计纠偏控制实验,以验证纠偏控制算法的工程适用性。实验表明,所提纠偏控制方法能够有效应用于实际纠偏过程,并应对和完成多种纠偏任务。     

Sericin-Based Poly(Vinyl) Alcohol Relieves Plaque and Epidermal Lesions in Psoriasis; a Chance for Dressing Development in a Specific Area

The noncontagious immune-mediated skin disease known as psoriasis is regarded as a chronic skin condition with a 0.09–11.4% global prevalence. The main obstacle to the eradication of the disease continues to be insufficient treatment options. Sericin, a natural biopolymer from Bombyx mori cocoons, can improve skin conditions via its immunomodulatory effect. Many external therapeutic methods are currently used to treat psoriasis, but sericin-based hydrogel is not yet used to treat plaques of eczema. Through the use of an imiquimod rat model, this study sought to identify the physical and chemical characteristics of a silk sericin-based poly(vinyl) alcohol (SS/PVA) hydrogel and assess both its therapeutic and toxic effects on psoriasis. The cytokines, chemokines, and genes involved in the pathogenesis of psoriasis were investigated, focusing on the immuno-pathological relationships. We discovered that the SS/PVA had a stable fabrication and proper release. Additionally, the anti-inflammatory, antioxidant, and anti-apoptotic properties of SS/PVA reduced the severity of psoriasis in both gross and microscopic skin lesions. This was demonstrated by a decrease in the epidermal histopathology score, upregulation of nuclear factor erythroid 2-related factor 2 and interleukin (IL)-10, and a decrease in the expression of tumor necrosis factor (TNF)-α and IL-20. Moreover, the genes S100a7a and S100a14 were downregulated. Additionally, in rats given the SS/PVA treatment, blood urea nitrogen, creatinine, and serum glutamic oxaloacetic transaminase levels were within normal limits. Our findings indicate that SS/PVA is safe and may be potentiated to treat psoriasis in a variety of forms and locations of plaque because of its physical, chemical, and biological characteristics.     

Tumor-Microenvironment Characterization of the MB49 Non-Muscle-Invasive Bladder-Cancer Orthotopic Model towards New Therapeutic Strategies

Bacillus Calmette-Guérin (BCG) instillations for the treatment of non-muscle-invasive bladder cancer patients can result in significant side effects and treatment failure. Immune checkpoint blockade and/or decreasing tumor-infiltrating myeloid suppressor cells may be alternative or complementary treatments. Here, we have characterized immune cell infiltration and chemoattractant molecules in mouse orthotopic MB49 bladder tumors. Our data show a 100-fold increase in CD45⁺ immune cells from day 5 to day 9 tumors including T cells and mainly myeloid cells. Both monocytic myeloid-derived suppressor-cells (M-MDSC) and polymorphonuclear (PMN)-MDSC were strongly increased in day 9 tumors, with PMN-MDSC representing ca. 70% of the myeloid cells in day 12 tumors, while tumor associated macrophages (TAM) were only modestly increased. The kinetic of PD-L1 tumor expression correlated with published data from patients with PD-L1 expressing bladder tumors and with efficacy of anti-PD-1 treatment, further validating the orthotopic MB49 bladder-tumor model as suitable for designing novel therapeutic strategies. Comparison of chemoattractants expression during MB49 bladder tumors grow highlighted CCL8 and CCL12 (CCR2-ligands), CCL9 and CCL6 (CCR-1-ligands), CXCL2 and CXCL5 (CXCR2-ligands), CXCL12 (CXCR4-ligand) and antagonist of C5/C5a as potential targets to decrease myeloid suppressive cells. Data obtained with a single CCR2 inhibitor however showed that the complex chemokine crosstalk would require targeting multiple chemokines for anti-tumor efficacy.     

Parameter inference in a computational model of haemodynamics in pulmonary hypertension

Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) greater than 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary arterial compliance. There are few measurable biomarkers of PH progression, but a conclusive diagnosis of the disease requires invasive right heart catheterization (RHC). Patient-specific cardiovascular systems-level computational models provide a potential non-invasive tool for determining additional indicators of disease severity. Using computational modelling, this study quantifies physiological parameters indicative of disease severity in nine PH patients. The model includes all four heart chambers, the pulmonary and systemic circulations. We consider two sets of calibration data: static (systolic and diastolic values) RHC data and a combination of static and continuous, time-series waveform data. We determine a subset of identifiable parameters for model calibration using sensitivity analyses and multi-start inference and perform posterior uncertainty quantification. Results show that additional waveform data enables accurate calibration of the right atrial reservoir and pump function across the PH cohort. Model outcomes, including stroke work and pulmonary resistance-compliance relations, reflect typical right heart dynamics in PH phenotypes. Lastly, we show that estimated parameters agree with previous, non-modelling studies, supporting this type of analysis in translational PH research.     

SQL Server 2000触发器运行机制的逻辑分析

对初学者来说,触发器运行机制还是很复杂和抽象的。为SQL Server2000的触发器运行过程建立一个直观易于理解的逻辑上的模型,能够粗浅的解释触发器的运行机制,从而使触发器运行机制学习变得更加容易。     

CFRP约束高温后混凝土力学性能试验研究

以混凝土经历的最高温度和CFRP布层数为参数进行了CFRP约束高温后混凝土力学性能试验研究。通过实测应力-应变曲线,研究温度和CFRP布层数对CFRP约束高温后混凝土抗压强度、极限应变和初始刚度等力学性能指标的影响规律。试验结果表明,CFRP约束显著影响了高温后混凝土受压破坏形态,并大幅度提高了高温后混凝土强度,说明CFRP约束可作为火灾后混凝土结构的一种有效的抢修与加固措施。同时,综合分析温度软化效应和CFRP约束强化效应对混凝土抗压强度的影响,CFRP约束强化效应处于主导地位。此外,在现有模型的基础上,提出了评估CFRP约束高温后混凝土力学性能的简化模型,经试验结果验证,该简化模型具有良好的精确性与实用性。