肺癌组织中SOX4突变蛋白三级结构的建模及分析

SOX家族与很多人类肿瘤的发生有关.对人类肺癌组织中的SOX4进行测序,发现该基因HMG-box区有突变发生并导致SOX4蛋白的107密码子发生突变.以三级结构已知的SOX2为模板,采用同源建模方法对突变和正常SOX4蛋白FMG-box进行建模.结果显示突变和正常SOX4蛋白的三级结构很相似,且突变导致107密码子位置的侧链结构不稳定.提示该位置的不稳定可能会影响突变SOX4蛋白侧链的弹性,并有可能影响相应蛋白的功能.表面静电分析显示SOX4蛋白C端有一个可能与其它小分子或蛋白质的相互作用位点的N/C腔.这些结果显示SOX4蛋白的上述空间结构可能与其活性与功能的调控有关,而SOX4突变可能与肺癌的发生和转移有关.     

烯烃催化裂解反应动力学的研究

根据脉冲微反条件下C5～C8烯烃裂解产物分布,建立烯烃裂解反应网络,通过参数估计方法确定反应网络动力学常数、反应活化能和指前因子.结果表明,随着碳数的增加,C5～C8烯烃单分子裂解反应速率加快.反应温度600℃时C5～C8正构烯烃裂解生成丙烯,其反应速率常数的比值为1:8.18:38.48:27.98,最快生成丙烯的是1-庚烯.反应温度相同,1-烯烃的主要裂解反应速率是碳数相同的2-甲基-2-烯烃的1.1～1.6倍.C5烯烃裂解为单、双分子裂化并存的反应体系,但双分子裂解反应速率远大于单分子裂解,双分子反应占优势.     

一种基于规范的可信协同系统分析设计框架

针对可信协同系统分析建模与设计问题,提出了RBN-T模型,分析了模型中的可信保障机制及策略.提出了基于RBN-T模型的可信协同系统分析建模过程,以具体的实例说明了RBN-T模型在可信协同系统分析建模与设计上的可用性.RBN-T模型把基于角色的规范管理提升到适合可信协同系统分析建模与设计的层次,从而有利于在协同系统开发的早期阶段就关注可信问题.     

试论非绘画专业的色彩教学法——高职学院的色彩课教学浅谈

要使完全没有色彩知识与造型意识的高等职业学校的学生,在不多的色彩课时计划内比较全面地了解和初步掌握色彩的基本表现技法,授课教师不但要有较深的色彩理论知识和过硬的色彩造型功底,还必须具有灵活多样的教学方法与实训指导技巧,更需要进行强化有效的实训教学手段。     

特定三维人脸建模方法综述

介绍人脸建模的研究背景、研究内容以及研究热点,总结近期三维人脸建模的常用方法及优缺点,展望今后人脸建模的研究方向。三维建模是计算机视觉和计算机图形学领域中一个基本的问题,人脸因其普遍性和特殊性,成为众多研究人员的研究目标。     

基于情境的突发公共事件应急管理系统研究

在突发公共事件的应急管理中,有效提升情境感知能力、及时确定风险级别是一个重要课题.在分析当前应急管理现状和存在问题的基础上,引入情境概念改进传统突发公共事件的应急管理机制,把情境明确、系统地集成到突发公共事件管理过程中,将预案制定和预案调用的过程情境化,重点研究了情境建模、获取和匹配等相关技术,从而为实现应急机制与情境管理的集成、提升突发公共事件应急管理系统的运转效率提供了理论支撑.     

Combined analytical solution of overland flow and sediment transport

With reference to the kinematic wave theory coupled with the hypothesis of constant linear velocity for the rating curve, rising limb analytical solutions have been calculated for overland flow, over an Hortonian-infiltrating surface, and sediment discharge. These analytical solutions are certainly easier to use than the numerical integration of the basic equations and they may be used to obtain an initial evaluation of the parameters of more complex models generally devised for complicated cases.Notation a exponent of the Horton law [T^–1] - b exponent of the rill erosion equation - B inter-rill erosion coefficient [ML^–m–2T ^m–1] - c sediment concentration [ML^–3] - c _o reference sediment concentration [ML^–3] - E _I inter-rill erosion [ML^–2T^–1] - E _R rill erosion [ML^–2T^–1] - f _c final infiltration rate of the soil [LT^–1] - f _o initial infiltration rate of the soil [LT^–1] - h flow depth [L] - h _o reference flow depth [L] - i infiltration rate [LT^–1] - k rill erosion coefficient [ML^–1–b T^–1] - K integration constant - L() Laplace transformation - m exponent of the inter-rill erosion equation - n Manning's coefficient [L^–1/3T] - p rainfall intensity [LT^–1] - q water discharge per unit width [L²T^–1] - q _s sediment discharge per unit width [ML^–1T^–1] - t time [T] - t _p ponding time [T] - x distance along the flow direction [L] Greek Letters coefficient of the stage-discharge equation [L^2–T^–1] - exponent of the stage-discharge equation - rill erosion coefficient [L^–1]     

Economic modeling of board test strategies

A long and deep recession, coupled with continuous competitive pressure to reduce costs, is forcing many companies to review their test strategies. Testing costs have become a more significant proportion of the overall manufacturing cost even though manufacturing yields have increased dramatically over the past ten or twelve years. This causes attention to be focused on testing costs as a key source of cost reduction. The increased use of DFT and the integration of design and test are very positive moves towards controlling testing costs but other methods employed can often backfire. The increased use of low priced testers is one such method. The pressure to reduce costs, higher process yields and exhortations that testing adds no value can lead the test engineering manager to take the cheap route. In reality this can often turn out to be an expensive decision. The only way to avoid expensive mistakes is to perform an economic analysis of the alternative courses of action. In most cases this is done, but not always in the right manner or with the necessary amount of detail to make the comparisons meaningful. This article discusses the need for effective cost analysis of test strategies and highlights some of the pitfalls.     

考虑电网阻抗耦合的模块化多电平换流器交直流侧阻抗通用计算方法

以模块化多电平换流器(modular multilevel converter,MMC)为技术路线的柔性直流输电技术在风电接入、电网异步互联等领域迅速发展。MMC的阻抗建模是分析柔性直流输电系统振荡起源的重要依据。文中分析MMC在交、直流侧激励下的谐波传递机制,建立一种适用于交、直流侧阻抗计算的通用方法。对一次系统频域建模关联了MMC所连接的交、直流侧网络阻抗,并考虑包含解耦双同步参考坐标系锁相环及负序内环控制在内的全部控制模块。通过求解线性方程组对MMC阻抗进行计算,并在PSCAD/EMTDC环境中对双端背靠背MMC系统在多种工况下1～5kHz频段内进行扫频,验证该方法的准确性,并详细分析网络阻抗耦合、控制链路延时、功率等级、负序内环和外环控制等因素对MMC阻抗的影响。