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171.
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Giuseppina Emanuela Grieco Noemi Brusco Giada Licata Daniela Fignani Caterina Formichi Laura Nigi Guido Sebastiani Francesco Dotta 《International journal of molecular sciences》2021,22(2)
Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia mainly due to pancreatic β cell death and/or dysfunction, caused by several types of stress such as glucotoxicity, lipotoxicity and inflammation. Different patho-physiological mechanisms driving β cell response to these stresses are tightly regulated by microRNAs (miRNAs), a class of negative regulators of gene expression, involved in pathogenic mechanisms occurring in diabetes and in its complications. In this review, we aim to shed light on the most important miRNAs regulating the maintenance and the robustness of β cell identity, as well as on those miRNAs involved in the pathogenesis of the two main forms of diabetes mellitus, i.e., type 1 and type 2 diabetes. Additionally, we acknowledge that the understanding of miRNAs-regulated molecular mechanisms is fundamental in order to develop specific and effective strategies based on miRNAs as therapeutic targets, employing innovative molecules. 相似文献
174.
Marie Piollet Adrian Sturza Stphanie Chadet Claudie Gabillard-Lefort Lauriane Benoist Danina-Mirela Muntean Oana-Maria Aburel Denis Angoulvant Fabrice Ivanes 《International journal of molecular sciences》2021,22(2)
Vascular dysfunction in cardiovascular diseases includes vasomotor response impairments, endothelial cells (ECs) activation, and smooth muscle cells (SMCs) proliferation and migration to the intima. This results in intimal hyperplasia and vessel failure. We previously reported that activation of the P2Y11 receptor (P2Y11R) in human dendritic cells, cardiofibroblasts and cardiomyocytes was protective against hypoxia/reoxygenation (HR) lesions. In this study, we investigated the role of P2Y11R signaling in vascular dysfunction. P2Y11R activity was modulated using its pharmacological agonist NF546 and antagonist NF340. Rat aortic rings were exposed to angiotensin II (AngII) and evaluated for their vasomotor response. The P2Y11R agonist NF546 reduced AngII-induced vascular dysfunction by promoting EC-dependent vasorelaxation, through an increased nitric oxide (NO) bioavailability and reduced AngII-induced H2O2 release; these effects were prevented by the use of the P2Y11R antagonist NF340. Human vascular SMCs and ECs were subjected to AngII or H/R simulation in vitro. P2Y11R agonist modulated vasoactive factors in human ECs, that is, endothelial nitric oxide synthase (eNOS) and endothelin-1, reduced SMC proliferation and prevented the switch towards a synthetic phenotype. H/R and AngII increased ECs secretome-induced SMC proliferation, an effect prevented by P2Y11R activation. Thus, our data suggest that P2Y11R activation may protect blood vessels from HR-/AngII-induced injury and reduce vascular dysfunctions. These results open the way for new vasculoprotective interventions. 相似文献
175.
以松尾芭蕉为例,通过探讨古典俳句研究的三个新维度,即心理学维度、“大数据”维度以及“环保旅行”维度,挖掘蕉风俳句的多维度内涵和时代价值,希冀为俳句的审美、创作和价值研究开辟出一条新路。 相似文献
176.
针对一起500 kV线路故障进行分析,确定该线路分相电流差动保护跳闸位置开入异常,查出跳闸位置开入异常是由厂家配线错误导致的。本次异常处理对变电二次检修、基建验收等环节有一定的借鉴意义。 相似文献
177.
本文通过模拟地下管道阴极保护的现场,测定了地下的杂散电流及其对阴极保护效果的影响,并对相关问题进行了分析。 相似文献
178.
本文从热处理工艺设计入手,阐述了工艺设计的衡量标准以及环保的重要性,论述了热处理工艺设计的特点和工程设计人员的任务。 相似文献
179.
Thermal sprayed aluminum and zinc provide long-term (> 20 years to first maintenance) corrosion control coatings. However,
this application is usually more expensive than painting or galvanizing if thermal spraying (metallizing) is not integrated
into the design and fabrication phases of new construction and repair projects. Aluminum and zinc metallized coatings are
tough enough to withstand fabrication, transportation, and assembly operations. The improved capabilities and productivity
of metallizing equipment for aluminum and zinc spraying are a major factor in their current cost competitiveness. The net
result is that the cost difference between metallizing, paint, and galvanizing is getting closer every day. Even though the
initial application cost of metallizing may be higher, the life cycle cost (LCC) and average equivalent annual costs (AEAC)
are lower than paint coating systems. Metallizing LCCs, when properly engineered into the construction schedule, are equal
to or less than paint coating LCCs. This article summarizes some metallizing considerations for installing improved corrosion
control coating systems in new construction and in maintenance and repair of infrastructure.
Editor’s Note: The following constants have been used to convert between English and Metric dimensions: 1ft2-0.0929 m2; 1lb/ft2-4.89 kg/m2; 1 mil=0.025mm.
Presented at the 5th National Thermal Spray Conference (NTSC-93), Infrastructure Maintenance and Repair Session, 10 June 1993,
Anaheim, CA. 相似文献
180.
中国一次能源和负荷成逆向分布,新能源基地集群通过特高压直流群外送,新能源高占比电网中风电和直流耦合关系复杂。首先,建立电网分析模型,研究风电和直流在电网频率、电压方面的耦合关系。其次,根据最大频率偏差耐受能力,计算风电和直流在频率方面的耦合关系。再次,根据直流闭锁故障后风电暂态过电压总脱网量约束,推导风电并网点的暂态压升,计算暂态压升和脱网量的关系,得到直流和风电在暂态过电压方面的耦合关系。理论计算结果表明:风电和直流呈负相关性。根据2020年西北电网青豫直流和近区风电并网功率的仿真结果,验证了理论推导的正确性。 相似文献