Anti-Inflammatory Activity of Oat Beta-Glucans in a Crohn’s Disease Model: Time- and Molar Mass-Dependent Effects

Background: The incidence of Crohn’s disease (CD) is increasing worldwide, and it has currently become a serious public health issue in society. The treatment of CD continues throughout a patient’s lifetime, and therefore, it is necessary to develop new, effective treatment methods, including dietotherapy. The present study aimed to determine the effects of consumption of oat beta-glucans with different molar mass on colon inflammation (colitis) in the early stages of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced CD in an animal model. Methods: Sprague–Dawley rats (control and TNBS-induced CD) were divided into three dietary groups and fed for 3 days (reflecting acute inflammation) or 7 days (reflecting remission) with a feed containing 1% low (βGl) or high (βGh) molar mass oat beta-glucan or a feed without this polysaccharide. The level of colon inflammatory markers and the expression of cytokines and their receptor genes were measured by ELISA and RT-PCR methods, respectively. Results: Acute inflammation or remission (3 or 7 days after TNBS administration, respectively) stages of experimentally induced CD were characterized by an increase in the level of inflammatory markers (IL-1, IL-6, IL-10, IL-12, TNF-α, CRP, MPO, COX, and PGE2) and the disruption of some cytokine signaling pathways as well as macro- and microscopic changes of colon tissue. The consumption of oat beta-glucans reduced the level of inflammatory markers and recovered the signaling pathways and histological changes, with stronger effects of βGl after 7 days of colitis. Conclusions: Dietary oat beta-glucans can reduce colitis at the molecular and organ level and accelerate CD remission.     

关注区可变的实时仿真方法与平台

交直流混合电网的实时仿真既要考虑电力电子设备的开关特性,又要保证适应较大的电网规模,在实际工程中面临诸多困难.给子网络赋予动态可变的关注标志,对关注子网络采用存储压力小的节点消去法,对非关注子网络采用计算量少的线性组合法,从而保证骨架型节点电压法的实用性.在Xilinx公司的Virtex-7 FPGA VC709开发板中,采用无缝的并行化仿真计算程序对接方式和灵活的结构参数查询方法解决了现场可编程逻辑门阵列资源的紧缺问题,设计了一种关注区可变的实时数字仿真平台.以典型的交直流混合电网为例,仿真验证了所提方法的可行性与所研发平台的有效性.     

微电网跟踪调度计划双层双时间尺度实时控制策略

为了提升微电网跟踪调度计划的能力,并降低分布式电源和负荷的功率波动对跟踪效果的影响,提出一种利用由超级电容和电池储能组成的混合储能系统跟踪调度计划的双层双时间尺度实时控制策略。上层基于模型预测控制方法建立日内滚动优化模型,结合分布式电源和负荷的超短期功率预测结果,综合考虑一段时域内的跟踪偏差及混合储能系统的功率和荷电状态对跟踪调度计划进行滚动优化;下层在上层优化结果的基础上,采用基于荷电状态的混合储能系统实时控制策略对超级电容和电池储能的实时功率进行协调分配,进一步降低分布式电源和负荷的实时功率波动对跟踪效果的影响。通过仿真算例对所提控制策略进行验证,结果表明:所提策略不但实现了良好的实时跟踪调度计划的控制效果,而且优化了超级电容和电池储能的荷电状态。     

数控系统加减速控制与程序段终点速度规划

加减速控制是CNC系统的关键技术之一。以前的加减速控制技术通常或单独采用前加减速控制，或单独采用后加减速控制。本文提出一种采用前加减速控制，同时结合运用后加减速控制算法原理的策略并且在加工前选择速度曲线模型，以提高数控系统的加工精度、实时性和通用性。同时本文进一步分析了在数控系统加工过程中，在程序段终点处存在速度无规则突跳的现象，讨论了该现象所带来的问题并提出了解决这些问题的办法。     

A machine vision approach to seam tracking in real-time in PAW of large-diameter stainless steel tube

Manual monitoring and seam tracking through watching weld pool images in real-time, by naked eyes or by industrial TV, are experience-depended, subjective, labor intensive, and sometimes biased. So it is necessary to realize the automation of computer-aided seam tracking. A PAW (plasma arc welding) seam tracking system was developed, which senses the molten pool and the seam in one frame by a vision sensor, and then detects the seam deviation to adjust the work piece motion adaptively to the seam position sensed by vision sensor. A novel molten pool area image-processing algorithm based on machine vision was proposed. The algorithm processes each image at the speed of 20 frames/second in real-time to extract three feature variables to get the seam deviation. It is proved experimentally that the algorithm is very fast and effective. Issues related to the algorithm are also discussed.     

MES在聚氯乙烯生产中的应用

介绍了MES在聚氯乙烯生产中乙炔站、氯乙烯、聚合各工序的生产平衡、实时参数及关联参数优化、辅助材料的核算等应用情况。     

硅酸根分析仪在火电厂水处理中的应用

FIA－33型自动分析仪是采用先进的流动注射技术，固体冷光源光纤技术及现代微机技术相结合的一种智能型在线水质分析仪器，成功地实现 了锅炉水（汽）硅酸根的快速在线实时监测，阐述了硅酸根自动分析仪的特点，分析流程及工作原理，并结合近几年来的现场应用实践进行分析总结。     

"偶然"流溢在现代陶艺中的艺术魅力

现代陶艺作为一种工艺美术品,是某一种生活方式和审美思想与审美情趣的载体,是创作者在自己生命旅程中的每个驿站里对情感体悟的一个表达;它是一种记忆、一种记录,更是一种镌刻在生命中的永恒。所以说现代陶艺创作是在“偶然”间捕捉感觉,而并非是在刻意地塑造感觉。     

真核表达质粒pcDNA3.1(+)-Vasostatin的构建及其在293T细胞中的表达

目的构建真核表达质粒pcDNA3.1(+)-Vasostatin并检测其在真核细胞内的表达水平。方法将带有信号肽的Vasostatin基因片段克隆至pcDNA3.1(+)真核表达载体上,经酶切鉴定及测序分析证明构建成功后,以脂质体介导法转染293T细胞,通过Westernblot法,检测其在293T细胞内的表达水平。结果所构建的真核表达质粒pcDNA3.1(+)-Va-sostatin转染293T细胞后,在其裂解的上清液中,检测到目的基因的表达。结论已成功构建了pcDNA3.1(+)-Vasostatin表达载体,并在真核细胞中表达了目的蛋白。