Application of Proteomics in Pancreatic Ductal Adenocarcinoma Biomarker Investigations: A Review

Pancreatic ductal adenocarcinoma (PDAC), a highly aggressive malignancy with a poor prognosis is usually detected at the advanced stage of the disease. The only US Food and Drug Administration-approved biomarker that is available for PDAC, CA 19-9, is most useful in monitoring treatment response among PDAC patients rather than for early detection. Moreover, when CA 19-9 is solely used for diagnostic purposes, it has only a recorded sensitivity of 79% and specificity of 82% in symptomatic individuals. Therefore, there is an urgent need to identify reliable biomarkers for diagnosis (specifically for the early diagnosis), ascertain prognosis as well as to monitor treatment response and tumour recurrence of PDAC. In recent years, proteomic technologies are growing exponentially at an accelerated rate for a wide range of applications in cancer research. In this review, we discussed the current status of biomarker research for PDAC using various proteomic technologies. This review will explore the potential perspective for understanding and identifying the unique alterations in protein expressions that could prove beneficial in discovering new robust biomarkers to detect PDAC at an early stage, ascertain prognosis of patients with the disease in addition to monitoring treatment response and tumour recurrence of patients.     

Banach空间中非线性混合型脉冲积分-微分方程初值问题的解

研究了Banach空间中非线性脉冲积分-微分方程初值问题解的存在性。在比较宽松的紧性条件下,利用Mnch不动点定理,通过引进等价范数,递归法和拟幂零算子,建立了新的存在性定理,推广和改进了于立新和刘立山在2003所建立的相关结果。     

基于C#和AutoCAD的Delaunay三角剖分算法的实现

本文是在.net平台下AutoCAD二次开发方面的文章,是对Delaunay三角剖分算法的总结。在算法的编程实现过程中,作者提出了许多新颖的设想,并最终获得了正确的计算结果和理想的时间效率。针对算法实现的整体框架和步骤,几个算法关键点以及算法的时间复杂度方面,文中提供了比较详细的论述。     

建筑供热负荷模型结构的辨识

本文以一栋5029m~2的公共建筑21周实测数据为依据,提出了一种关于严寒地区建筑采暖负荷的CARMA 系统辨识模型.由此,可以根据室外温度的预报值及室内温度的期望值估计建筑采暖系统供热量.分析结果表明,实测值与预测值间的平均相对误差为6.45,从而说明了该种方法的有效性.这种方法也同样适用于城市小区供热量及小供热锅炉房的供热量预报.     

直立多层介质地面点源电场的递推公式

令电位边界条件的两个方程式相除并等于电阻率转换函数,由此得出两组求电位积分表达式中待定系数的递推公式。将已知层参数逐步代入第一组速推公式,求得电源点所在层的待定系数,然后用第二组递推公式得到其他层的待定系数。     

平行四边形网格上的递归曲面

文中利用直积的方法给出了平行四边形网格上递归曲面的定义，并由此引入了Ｌ曲面和Ｗ曲面，得到了Ｌ曲面的求导公式、基底表示、包络定理和把Ｌ曲面表示为等价的Ｂｅｚｉｅｒ曲面的表示公式．最后证明了平行四边形域上Ｗ曲面具有保凸性．     

信号快速变化且PRF未知时比幅单脉冲接收机的中放AGC系统

针对通常比幅单脉冲接收机中中放自动增益控制系统在信号强度快速变化及脉冲重复频率可变情况下遇到的困难,本文给出了一种新的中放自动增益控制系统.文中首先简要回顾了从时域性能出发进行AGC设计的概念,随后详细介绍了和、差中放与AGC电路的电路实现方法及相应的设计考虑,最后并给出了若干主要指标的测试结果及外场试验的一些结果.     

Cardiomyopathy associated with clozapine.

Clozapine is an atypical antipsychotic agent that is more effective than the standard neuroleptics currently used for treating refractory schizophrenia. In addition, clozapine is a drug with few extrapyramidal side effects. However, clozapine is also associated with potentially serious adverse effects, such as cardiac complications as well as agranulocytosis. Clozapine-related cardiomyopathy has not been previously reported in East Asia. This report describes a 31-year-old Korean male patient with schizophrenia who developed dilated cardiomyopathy on treatment with clozapine. The removal of clozapine caused subsequent physical improvement. However, the readministration of clozapine for managing relapse of psychosis caused a recurrence of dilated cardiomyopathy in this patient. Therefore, this is the 1st report showing that the 2nd trial of clozapine caused recurrence of cardiomyopathy associated with clozapine. Thus, this report adds important support for a causal relation between clozapine and cardiac complications. In conclusion, this report attempts to raise awareness of clozapine-related cardiomyopathy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

模糊聚类和边缘检测结合的彩色图像分割算法

提出模糊聚类和边缘检测结合的彩色图像分割方法,以色彩图像直方图中自适应搜索到的峰值作为聚类中心,对图像进行模糊聚类。然后对模糊聚类后的图像进行边缘检测,检测出面积较大的区域的边缘,首先在区域内部进行融合,然后在区域边界和面积较小色彩相似的区域融合。实验表明,本方法不需预先确定聚类数目、聚类中心初始化,在区域融合后,可得到较好的分割效果。     

分水岭算法在重叠细胞图象分割中的应用

分水岭算法是一种广泛使用的分割方法,将其用于细胞图象分割可以克服由于细胞交叠造成的图象分析困难,但缺陷在于它的过分割结果。本文给出一种针对分水岭过分割问题的解决方案,引入灰度差值图的概念,提出一种基于灰度差值图和距离图的变换,将变换结果作为分水岭算法的输入图象;最后对需要存在过分割的区域根据区域灰度性质合并过分割区域。