江苏沿海地区体育旅游资源开发研究

本文通过对江苏沿海地区体育旅游的资源优势和良好发展机遇的分析,设计了以海水、风、沙、湿地、山岳、海滨森林、海滨乡村、温泉和民族体育为基础的体育旅游产品,并提出了开发策略。     

全球主要铅锌矿业公司锌矿资源与开发利用及其对我国的启示

全球铅锌资源丰富、分布相对分散，全球主要铅锌公司通过相对集中的资源布局，掌控优质资源，配套发展铅锌冶炼-加工产产业，构建了完整的产业链资产组合，把握了行业竞争力和话语权。本文采用国际权威矿产资源专业数据库资料和国外矿业企业公开披露的数据，聚焦全球主要铅锌公司的铅锌资源状况，通过分析其主要项目的矿床类型及其分布特征，资源储量、品位及其勘探、开发利用情况等，认为国外矿业巨头均以资源保障能力掌控行业话语权与竞争力。同时通过我国矿企境外锌资源开发情况，揭示我国矿企“走出去”任重道远。笔者认为在全球实现“碳达峰、碳中和”的大背景下，环保安全整治、小矿山关停、在产矿山资源贫化等因素叠加影响下，我国矿业企业应继续积极“走出去”，在巩固国内铅锌矿山基本产量基础下，加大在境外优质资源的投资力度，提高境外权益矿产产量，实现企业大型化和国际化，为我国十四五高质量发展中国家大宗战略性矿产资源的保障能力贡献力量。     

[供应链调度]装卸一体化车辆路径问题的自适应并行遗传算法

为了同时实现总配送成本最低、车辆行驶距离最短、车辆数最小等目标,综合考虑车辆指派成本及运输路径成本,建立了装卸一体化车辆路径问题的混合整数规划模型。针对该问题搜索空间的离散性和求解算法的局部收敛性,提出了一种自适应并行遗传算法。算法以C-W节约法为基础,设计了三种基于双重需求的启发式种群初始化方法,缩小搜索空间并优化初始解;引入多样性种群和高质量种群的双种群并行策略,实现深度与广度的同步搜索;设计自适应交叉变异操作,改善高质量种群个体搜索停滞,并针对全局最优个体采用特殊变异的后优化操作以进一步提高全局优化性能。采用标准数据集作为算例进行寻优测试,验证了所提算法的可行性和有效性。     

工业涂料市场营销理念与策略

分析了工业涂料的市场特点,评述了传统营销和市场营销的理念差异,提出了市场营销的主要策略。     

一次风风量测控回路的改进方案

在大型火力发电厂一次风风量测控回路中,通过对伯努利低速能量方程的应用和推导,对流体系数的算法进行调整,得出了不同于常规采样截面的测量元件,使用该元件进行差压信号采集,成功通过了流场仿真。最后在回路的控制侧,采用了更加优化的策略,实现了一次风量的协调稳定控制。     

Ficolin-2 Plasma Level Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

Fibrosis is the strongest predictor for disease-specific mortality in non-alcoholic fatty liver diseases (NAFLD), but the need for liver biopsy limits its diagnosis. We assessed the performance of plasma ficolin-2 (FCN-2) as a biomarker of fibrosis identified by an in silico discovery strategy. Two hundred and thirty-five morbidly obese (MO) subjects with biopsy-proven NAFLD stratified by fibrosis stage (F0, n = 44; F1, n = 134; F2, n = 46; F3/F4, n = 11) and 40 cirrhotic patients were enrolled. The cohort was subdivided into discovery (n = 76) and validation groups (n = 159). The plasma level of FCN-2 and other candidate markers was determined. FCN-2 was inversely correlated with the stage of liver fibrosis (ρ = −0.49, p < 0.001) independently of steatosis (p = 0.90), inflammation (p = 0.57), and ballooning (p = 0.59). In the global cohort, FCN-2 level decreased significantly in a stepwise fashion from F0/F1 (median 4753 ng/mL) to F2–F3–F4 (2760 ng/mL) and in cirrhotic subjects (1418 ng/mL). The diagnostic performance of FCN-2 in detecting F ≥ 2 was higher than other indexes (APRI, FIB-4) (AUROC 0.82, 0.68, and 0.6, respectively). The accuracy improved when combined with APRI score and HDL values (FCNscore, AUROC 0.85). Overall, the FCN-2 plasma level can accurately discriminate liver fibrosis status (minimal vs. moderate/advanced) significantly improving the fibrosis diagnostic algorithms.     

Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from “Fear-Avoidance Belief”

It is well known that exercise produces analgesic effects (exercise-induced hypoalgesia (EIH)) in animal models and chronic pain patients, but the brain mechanisms underlying these EIH effects, especially concerning the emotional aspects of pain, are not yet fully understood. In this review, we describe drastic changes in the mesocorticolimbic system of the brain which permit the induction of EIH effects. The amygdala (Amyg) is a critical node for the regulation of emotions, such as fear and anxiety, which are closely associated with chronic pain. In our recent studies using neuropathic pain (NPP) model mice, we extensively examined the association between the Amyg and EIH effects. We found that voluntary exercise (VE) activated glutamate (Glu) neurons in the medial basal Amyg projecting to the nucleus accumbens (NAc) lateral shell, while it almost completely suppressed NPP-induced activation of GABA neurons in the central nucleus of the Amyg (CeA). Furthermore, VE significantly inhibited activation of pyramidal neurons in the ventral hippocampus-CA1 region, which play important roles in contextual fear conditioning and the retrieval of fear memory. This review describes novel information concerning the brain mechanisms underlying EIH effects as a result of overcoming the fear-avoidance belief of chronic pain.     

面向主动探测式保护的变流器正交控制策略

为避免主动探测式保护的变流器附加控制策略与原有基础控制策略之间相互干扰,提出了一种正交控制的方法。首先分析了新型电力系统中变流器的基础控制策略,针对空间矢量脉宽调制采用正序分量计算空间矢量的特点,设计了基于负序分量的附加控制策略,保证基础控制系统、附加控制系统相互解耦。其次利用基础和附加控制策略处理后的不同信号频带,引入前置滤波环节,给出了常规应用场景下的正交控制策略;然后研究了脉冲信号的生成方式,分析了附加控制策略的适用场景;最后分析了探测信号生成对一次系统和传统保护的影响。     

计及碳市场和绿证市场的配电网投资效益动态评估

随着碳排放权交易机制和绿证交易机制的持续完善,配电网投资效益评估需综合考虑电力市场与碳市场及绿证市场间的交互影响。建立电-碳-绿证市场协同运营架构,剖析碳市场、绿证市场对配电网投资决策的因果反馈关系。从发购电、碳排放权交易、绿证交易、可再生能源消纳责任权重和投资效益5个层面搭建系统动力学子模块,提出计及碳市场和绿证市场耦合关系的配电网投资效益动态评估模型。算例仿真结果表明,所提模型在提高配电网投资效益的同时可减少碳排放以及提高可再生能源消纳责任权重。     

一种使用区块链保护车联网数据隐私的方法

随着物联网的快速发展和成熟,汽车工业领域的应用正经历着从早期的车辆Ad-Hoc网络到车联网的快速转变,数以万计的车辆及其搭载的各种车载设备都将通过车联网实现车辆或驾驶数据的共享和交互,而这些海量的数据的存储以及其中的大量用户隐私和数据安全问题带来巨大的挑战,尤其是访问控制、信任和密钥托管问题.针对该问题提出了一种基于区...