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961.
主曲线是一种新的基于非线性变换的特征抽取方法,它是一种通过数据分布“中间”并满足“自相合”的光滑曲线来进行特征提取的方法。为了提高手写数字串切分的正确率,提出了一种基于笔划组合的手写数字串切分方法。该方法首先使用主曲线完成字符模板的笔划抽取,然后以字符识别器提供的置信度为依据来组合笔划,以实现手写数字串的切分过程。另外,在字符识别器设计方面,则是使用基于数字轮廓分段特征与规范化模板特征这两个单特征分类器组合。实验表明,分别基于这两个特征的分类器具有较强的互补性。由于字符识别器的置信度难以真实反映识别结果,为此需使用类条件置信变换法,通过估计分类器的后验概率来对识别器的置信度进行修正。实验结果表明,该方法对于手写数字的分割是有效的。 相似文献
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用微波前向散射法探究出血性脑中风的出血量。该法利用脑出血状态及正常大脑状态下收发天线之间传输系数的幅度S21 和相位渍S21 差值变化、以及大脑的电场分布数值的变化来检测脑中风出血位置。文中用三维人体组织电磁仿真软件Sim4Life 提供精细的大脑模型,在大脑中植入直径为10 mm、20 mm、30 mm 的血球模型,并将三个血球模型置于大脑同一位置,然后搭建模拟脑出血的实验平台进行实测,由不同规格的试管模拟不同规格的出血量,最终验证了仿真结果与实验结果一致。实验证明,大脑出血量越大对收发天线间传输系数以及电场强度的影响越大。 相似文献
966.
Tianyuan Zhang Fangyuan Li Qianhao Xu Qiyue Wang Xinchi Jiang Zeyu Liang Hongwei Liao Xianglei Kong Jianan Liu Honghui Wu Danping Zhang Changhua An Liang Dong Yang Lu Hongcui Cao Dokyoon Kim Jihong Sun Taeghwan Hyeon Jianqing Gao Daishun Ling 《Advanced functional materials》2019,29(24)
Unsatisfactory post‐stroke recovery has long been a negative factor in the prognosis of ischemic stroke due to the lack of pharmacological treatments. Mesenchymal stem cells (MSCs)‐based therapy has recently emerged as a promising strategy redefining stroke treatment; however, its effectiveness has been largely restricted by insufficient therapeutic gene expression and inadequate cell numbers in the ischemic cerebrum. Herein, a non‐viral and magnetic field‐independent gene transfection approach is reported, using magnetosome‐like ferrimagnetic iron oxide nanochains (MFIONs), to genetically engineer MSCs for highly efficient post‐stroke recovery. The 1D MFIONs show efficient cellular uptake by MSCs, which results in highly efficient genetic engineering of MSCs to overexpress brain‐derived neurotrophic factor for treating ischemic cerebrum. Moreover, the internalized MFIONs promote the homing of MSCs to the ischemic cerebrum by upregulating CXCR4. Consequently, a pronounced recovery from ischemic stroke is achieved using MFION‐engineered MSCs in a mouse model. 相似文献
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Air-writing is a new human and smart device communication approach, permits users to write inputs in a natural and relentless way. This touch-less way can prevent users from virus infection such as COVID-19. Compared with other methods, air writing is more challenging due to its unique characteristics such as redundant lifting strokes, multiplicity (different writing styles from various users), and confusion (different character types written in air are similar). Without the need of any starting trigger, a novel reverse time-ordered algorithm is proposed in this paper to efficiently filter out unnecessary lifting strokes, and thus simplifies the matching procedure. As to the second and third issues, a tiered arrangement structure is proposed by sampling the air-writing results with various sampling rates to solve the multiplicity and confusion problems. Analyzed with other recently proposed air writing algorithms, the proposed approach reaches satisfactory recognition accuracy (above 94%) without any starting triggers. 相似文献
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Yifei Lu Chao Li Qinjun Chen Peixin Liu Qin Guo Yu Zhang Xinli Chen Yujie Zhang Wenxi Zhou Donghui Liang Yiwen Zhang Tao Sun Weigen Lu Chen Jiang 《Advanced materials (Deerfield Beach, Fla.)》2019,31(21)
Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, and brain vascular impairment occur within neurovascular units, leading to microthrombus formation and ultimate neuron death. In this work, a multitarget micelle system is developed to simultaneously modulate various cell types involved in these events. Briefly, rapamycin is encapsulated in self‐assembled micelles that are consisted of reactive oxygen species (ROS)‐responsive and fibrin‐binding polymers to achieve micelle retention and controlled drug release within the ischemic lesion. Neuron survival is reinforced by the combination of micelle facilitated ROS elimination and antistress signaling pathway interference under ischemia conditions. In vivo results demonstrate an overall remodeling of neurovascular unit through micelle polarized M2 microglia repair and blood–brain barrier preservation, leading to enhanced neuroprotection and blood perfusion. This strategy gives a proof of concept that neurovascular units can serve as an integrated target for ischemic stroke treatment with nanomedicines. 相似文献