Reliability Modeling for Ultrathin Gate Oxides Subject to Logistic Degradation Processes with Random Onset Time

With device dimension downscaling, the oxide thickness reduction less than 3 nm in a metal–oxide–semiconductor structure has led to important changes in degradation mechanisms and failure modes. After the first breakdown event of ultrathin gate oxides, the leakage current presents a less dramatic and noisy continuous breakdown mode called progressive breakdown. In this article, we characterize the overall breakdown process of ultrathin gate oxides as a randomized logistic degradation process with a random onset time. The explicit result of the lifetime distribution is derived on the basis of this logistic degradation model. A numerical example is provided to calculate the lifetime distribution. The simulated lifetime data of our model fits lognormal distribution better than the Weibull distribution, which agrees with the experimental work in literature. Copyright © 2012 John Wiley & Sons, Ltd.     

一种改进的气动弹性时域推进方法

针对气动弹性控制方程,结构项采用标准龙格库塔方法推进,广义气动力项采用时间上的插值技术,发展了一种在每一时间步内只用计算一次非定常气动力的近似四阶龙格库塔推进方法。通过计算非线性Bernoulli方程和某一超音速翼面的气动弹性响应,证明该方法的时间准确度远高于采用气动力冻结技术的四阶龙格库塔方法。其准确度与标准龙格库塔方法相差不大,而其调用非定常气动力求解器的次数仅为其四分之一,大大提高了气动弹性数值模拟的效率。对于一般的气动弹性响应而言,该时间推进方法只用保证每个周期内的时间步在20～30个左右就能满足较高的准确度要求。     

A Method for Automatically Establishing a Mathematical Model of Kinematic Analysis to a Planar Mechanism with a Multiple Joint and Prismatic Pair

A method for automatically establishing a mathematical model of kinematic analysis to a planar mechanism with multiple joint and prismatic pair is presented.The breadth(or depth) first search spanning tree can be obtained based on an adjacency matrix of the mechanism.Then the kinematic chain(or mechanism)’s basic loops can be obtained.On the basis of these basic loops,a mathematical model of kinematic analysis can be established and solved automatically.In the sense of a calculative mechanism,structural analysis of the kinematic chain relates to the kinematic analysis of a mechanism.Thus,an effective way is supplied to the given mechanism’s kinematic analysis for automatic modeling and solving,and a method is supplied to the structural type to optimize kinematic synthesis.     

丁腈橡胶在燃气介质中的老化性能测试研究

基于烘箱热空气老化试验方法,建立了一种能让试验样品处于流通气氛冲刷的闭合试验装置,对橡胶材料进行燃气环境中老化性能测试。选用丁腈橡胶为试样,测试其在不同温度、不同气氛下的老化性能,预测其使用时间。测试结果显示,采用空气气氛方法进行丁腈橡胶加速老化试验,预测的使用时间结果与实际使用时间的偏差在80%以上;燃气气氛冲刷环境下,丁腈橡胶在老化速率是热空气老化的2倍左右,且燃气气氛下的加速老化使用时间的预测结果与实际的偏差在±20%之内。     

SURFACE ROUGHNESS OF SPUTTERED SILICON. II. MODEL VERIFICATION

Experimental verification of the mathematical surface roughness model for sputtered silicon was performed. The beam shape and its significant level of intensity were determined first by measuring the topography of craters sputtered by focused ion beam (FIB). Then the beam function was generated for various combinations of beam parameters. The material function was developed both by theoretical and experimental analysis. These two functions were then used in the model to calculate the theoretical surface roughness. Microsurface analysis was formed by FIB sputtering of a (100) silicon wafer. The surface roughness at the bottom of the sputtered features was then measured using an atomic force microscope. The theoretical surface roughness was found to be within ±1 and ±5 nm of the measured surface roughness with the measurement uncertainty (standard deviation) of about ±0.36 and ±0.85 nm for R_a and R_t, respectively.     

Alpha-Synuclein Autoimmune Decline in Prodromal Multiple System Atrophy and Parkinson’s Disease

Multiple-system trophy (MSA) and Parkinson’s Disease (PD) are both progressive, neurodegenerative diseases characterized by neuropathological deposition of aggregated alpha-synuclein (αSyn). The causes behind this aggregation are still unknown. We have reported aberrancies in MSA and PD patients in naturally occurring autoantibodies (nAbs) against αSyn (anti-αSyn-nAbs), which are important partakers in anti-aggregatory processes, immune-mediated clearance, and anti-inflammatory functions. To elaborate further on the timeline of autoimmune aberrancies towards αSyn, we investigated here the Immunoglobulin (Ig) affinity profile and subclass composition (IgG-total, IgG1-4 and IgM) of anti-αSyn-nAbs in serum samples from prodromal (p) phases of MSA and PD. Using an electrochemiluminescence competition immunoassay, we confirmed that the repertoire of high-affinity anti-αSyn-nAbs is significantly reduced in pMSA and pPD. Further, we demonstrated that pPD had increased anti-αSyn IgG-total levels compared to pMSA and controls, concordant with increased anti-αSyn IgG1 levels in pPD. Anti-αSyn IgG2 and IgG4 levels were reduced in pMSA and pPD compared with controls, whereas anti-αSyn IgG3 levels were reduced in pMSA compared to pPD and controls. The results indicate that the impaired reactivity towards αSyn occurs prior to disease onset. The apparent lack of high-affinity anti-αSyn nAbs may result in reduced clearance of αSyn, leading to aggregation of the protein. Thus, this study provides novel insights into possible causes behind the pathogenesis in synucleinopathies such as MSA and PD.     

The mTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data

This article recapitulates the evidence on the role of mammalian targets of rapamycin (mTOR) complex pathways in multiple sclerosis (MS). Key biological processes that intersect with mTOR signaling cascades include autophagy, inflammasome activation, innate (e.g., microglial) and adaptive (B and T cell) immune responses, and axonal and neuronal toxicity/degeneration. There is robust evidence that mTOR inhibitors, such as rapamycin, ameliorate the clinical course of the animal model of MS, experimental autoimmune encephalomyelitis (EAE). New, evolving data unravel mechanisms underlying the therapeutic effect on EAE, which include balance among T-effector and T-regulatory cells, and mTOR effects on myeloid cell function, polarization, and antigen presentation, with relevance to MS pathogenesis. Radiologic and preliminary clinical data from a phase 2 randomized, controlled trial of temsirolimus (a rapamycin analogue) in MS show moderate efficacy, with significant adverse effects. Large clinical trials of indirect mTOR inhibitors (metformin) in MS are lacking; however, a smaller prospective, non-randomized study shows some potentially promising radiological results in combination with ex vivo beneficial effects on immune cells that might warrant further investigation. Importantly, the study of mTOR pathway contributions to autoimmune inflammatory demyelination and multiple sclerosis illustrates the difficulties in the clinical application of animal model results. Nevertheless, it is not inconceivable that targeting metabolism in the future with cell-selective mTOR inhibitors (compared to the broad inhibitors tried to date) could be developed to improve efficacy and reduce side effects.     

经济评价方法中内部收益率的分析与研究

内部收益率是经济评价中的一项重要指标,反映项目收回投资时间的快慢,可用试差法计算,也可近似等于偿还期的倒数.     

基于GPCA的中部省际农村居民生活水平动态分析

文章首先构建评价农村居民生活水平的指标体系,之后运用全局主成分分析法（GPCA）,实证研究了我国中部各省农村居民从2001年－2006年生活水平的时间演变,并对结果进行了比较分析。