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201.
202.
Fatin N. Mohd Jaya Sergio G. Garcia Francesc E. Borras Dolores Guerrero Godfrey C. F. Chan Marcella Franquesa 《International journal of molecular sciences》2021,22(9)
Regulatory B (Breg) cells are endowed with immune suppressive functions. Various human and murine Breg subtypes have been reported. While interleukin (IL)-10 intracellular staining remains the most reliable way to identify Breg cells, this technique hinders further essential functional studies. Recent findings suggest that CD9 is an effective surface marker of murine IL-10 competent Breg cells. However, the stability of CD9 and its relevance as a unique marker for human Breg cells, which have been widely characterized as CD24hiCD38hi, have not been investigated. Here, we demonstrate that CD9 expression is sensitive to in vitro B cell stimulations. CD9 expression could either be re-expressed or downregulated in purified CD9-negative B cells and CD9-positive B cells, respectively. We found no significant differences in the Breg differentiation capacity of the CD9-negative and CD9-positive B cells. Furthermore, CD9-positive B cells co-express CD40 and CD86, suggesting their nature as B cell activation or co-stimulatory molecules, rather than regulatory ones. Therefore, we report the relatively unstable CD9 as a distinct surface molecule, indicating the need for further research for a more reliable marker to purify human Breg cells. 相似文献
203.
The true stress--strain curves of TC16 alloy with a wide range of strain rates were investigated under uniaxial quasi-static tension and uniaxial dynamic compression with the lnstron 8032 test machine and the split Hopkinson bar respectively. The results indicate that the true stress increases with increasing strain rate, while decreases with increasing temperature. Under the 105 s^-1 high strain rate and temperature higher than 673 K, the true stress would even be less than that under quasi-static condition. A new method incorporating TCl6's stress strain curve developing item was proposed to determine the coefficients in J-C model easily and to avoid the estimation of the adiabatic temperature rising. The Johnson-Cook dynamic constitutive relationship for TC16 was obtained for the first time. Good agreement was obtained between the model prediction and the experimental stress--strain curves for TC16 under both quasi-static and dynamic loadings. 相似文献
204.
This paper investigates the interfacial structure in hot-wall CVD TiN/κ-Al2O3 multilayer coatings using both HREM and DFT modeling. Two multilayers with different thicknesses of the TiN layers (50 and 600 nm) separating the κ-Al2O3 layers are analyzed. The general microstructure of the two multilayers is relatively similar. The TiN layer in the thicker TiN/κ-Al2O3 coating is thick enough to be several TiN grains high. This means that epitaxial columns, which are often found in the thinner TiN/κ-Al2O3 coatings, are not present. However, the orientation relationships at the TiN/κ-Al2O3 interfaces are the same in both multilayers. The HREM investigations show that κ-Al2O3 (001) planes can grow directly on flat (111) TiN faces, without any other phases or detectable amounts of impurities, such as sulphur, present. Where the TiN layers are more curved, γ-Al2O3 can be grown, at least partly stabilized by the cube-on-cube orientation relationship between γ-Al2O3 and the underlying TiN. The DFT calculations show very similar adsorption strengths for an O monolayer positioned on Ti-terminated TiC(111) and TiN(111) surfaces, with preferred adsorption in the fcc site. O adsorption on N-terminated TiN(111) is much weaker, with preferred adsorption in the top site. Calculated elastic-energy contributions yield a higher stability for κ-Al2O3 on TiN(111) than on TiC(111) and a higher stability for κ-Al2O3 than for α-Al2O3 on both TiC and TiN. This indicates that the observed higher stability of κ-Al2O3 on TiC(111) than on TiN(111) is not due to the lattice mismatch, while the preferred epitaxial growth of κ-Al2O3 over α-Al2O3 can be partly attributed to the mismatch. 相似文献
205.
针对传统平面定位平台拓扑优化设计过程中无法预先了解输入输出位移映射矩阵的问题,基于固体各向同性材料惩罚法,采用遗传算法优化得到具有最大运动空间时的平面并联机构雅克比矩阵作为平面定位平台输入输出期望位移映射矩阵,在相同输入条件下,建立以机构实际运动与期望运动间误差最小为目标函数和以机构体积为约束函数的平面定位平台拓扑优化模型并求解。通过3D打印方式得到实验样品,实验与仿真分析表明:采用运动误差约束的平面定位平台拓扑优化设计方法,在一定偏差范围能够得到输入输出位移映射矩阵与给定期望映射矩阵相一致的平面定位平台,表明该方法对平面定位平台设计具备有效性,为其后续研究提供基础。 相似文献
206.
The technology of cold pressure welding was adopted to achieve the bonding of Al/Cu(limited soluble and forming compounds),Ag/Ni(hardly mutual soluble),and the relative state of interface was tested by HREM.The results indicate that stable interface is always corresponding to the low interfacial energy value;the stable interface is not coherent but partly-coherent because of the twisting of grain boundary caused by pressure,meanwhile existing dislocation.Namely,the interfacial match and other states under the condition of cold pressure welding are different from the situation that under the condition of thermal action.Moreover,theoretical analyses and calculation on the base of thermodynamics,crystallogeny ,solid physics etc,were discussed. 相似文献
207.
208.
原位反应自发渗透法TiC/AZ91D镁基复合材料及AZ91D镁合金的拉伸变形与断裂行为 总被引:9,自引:0,他引:9
利用原位反应自发渗透技术合成了47.5%碳化钛TiC(体积分数,下同)增强AZ91D镁基复合材料,对比研究了该复合材料与铸态镁合金AZ91D基体的室温与高温拉伸变形行为,观察了拉伸断口微观组织形貌,并分析了这两种材料的断裂特征。结果表明,TiC/Mg复合材料具有良好的高温力学性能,在拉伸变形速率为0.001s^-1以及温度为723K,时其拉伸强度可达91.1MPa,而此时相同变形条件下的铸态AZ91D镁合金拉伸断裂强度只有41.1MPa,增幅达120%。而在室温下,镁基复合材料的拉伸断裂强度仅高出基体铸态镁合金23.4%。镁基复合材料的断裂应变较低,高低温时均表现为脆性断裂;而镁合金则由室温下的脆性断裂向高温下的韧性断裂过渡。 相似文献
209.
采用真空热压工艺制备了含SiC颗粒体积分数分别为5%,15%和25%的SiC颗粒增强铝基复合材料,利用Hopkinson高速压杆冲击实验系统对其从静态到动态(应变率为3.3×10-3s-1~5.2×103s-1)的压缩破坏响应进行了研究,结合其光学显微镜分析变形组织,分析了不同体积分数SiCp/Al复合材料高应变率压缩载荷下,材料的变形和微观损伤机理.结果表明,复合材料存在应变率敏感性,SiC含量的增加导致复合材料应变率敏感性的增加,以垂直于载荷方向的增强相颗粒的剪切开裂为主要破坏模式. 相似文献
210.