A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)‐boron dipyrromethene amphiphile (PEG‐F₅₄‐BODIPY) with 54 fluorine‐19 (¹⁹F) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG‐F₅₄‐BODIPY). The as‐prepared PFH@PEG‐F₅₄‐BODIPY can perform architecture‐dependent fluorescence/photoacoustic/¹⁹F magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self‐quenching of BODIPY molecules. More interestingly, PFH@PEG‐F₅₄‐BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single‐dose intravenous injection. The “all‐in‐one” photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.     

Novel high-energy ionic molecules deriving from new monovalent and divalent 4-oxyl-3,5-dinitropyrazolate moieties

ABSTRACT

In recent years, the exploration of a practical strategy for novel energetic molecules with high energy and low sensitivity is very desirable but highly challenging. Novel ionic energetic molecules have attracted much attention in this area due to their prominent advantages including low sensitivities, high thermal stability, and excellent energy performances. Herein, five different ionic energetic molecules based on new monovalent and divalent 4-oxyl-3,5-dinitropyrazolate moieties with enhanced oxygen balance have been synthesized, characterized and evaluated as potential high-energy materials. Thermal stability, sensitivities and energy output test were measured and studied in detail. The heats of formation and energetic parameters were calculated by using Gaussian 09 suite of programs and EXPLO 5 code. The results suggest that all as-prepared new molecules exhibit good thermal stability with high decomposition temperature (3, 231°C; 5, 160°C; 6, 185°C; 7, 180°C; 8, 213°C), and relative low sensitivity (IS > 20 J, FS = 324 N). Inheriting the significant oxygen content of monovalent and divalent 4-oxyl-3,5-dinitropyrazolate moieties, they also possess good energy properties (v _D = 8238 ~ 9208 m s^?1, P = 26.8 ~ 36.7 GPa, V _o = 481.8 ~ 959.4 L kg^?1), which make them competitive high-energy materials.     

Effects of Agaricus bisporus on gel properties of chicken myofibrillar protein

The gel-forming ability of myofibrillar protein (MP) is highly correlated with the characteristics of emulsified meat products. Incorporation of Agaricus bisporus (Ab) powder into MP gels may enhance its gel properties to facilitate the development of a novel and safe meat product. Therefore, this study investigated the effects of Ab powder on gel strength, water holding capacity (WHC), texture, rheological behaviour, LF-NMR spin–spin relaxation (T₂), microstructure and protein secondary structure of the MP gel system. The results indicated that the gel strength, WHC, G' value and G" value were significantly improved when the addition of Ab powder increased from 0% to 6% (P < 0.05). Meanwhile, the T₂ relaxation time was shortened, and free water was transformed into immobilised water. The texture of the gel was improved when 1%–4% Ab powder was added compared to the control. Furthermore, Ab filled in the gel network and promoted the unfolding of MP α-helix and the formation of MP β-sheet during the thermal denaturation of MP, leading to a dense aggregated network structure. The study suggested that Ab could be a promising ingredient in improving chicken MP's gel properties and developing fat-reduced meat products.     

低应变配合静载测试在基桩检测中的应用

结合工程实例，论述了低应变检测配合静载测试的必要性及应注意的问题，着重介绍了对缺陷桩承载力的检测过程及分析思路。     

铜山铜矿床探采对比分析

选取铜山铜矿具有代表性的铜山矿段1号矿体、前山矿段4号矿体、前山南矿段30号矿体，将地质勘探资料与回采后地质资料所确定的矿体的形态、厚度、底板位移、资源储量等参数进行对比。分析了矿体勘、采资料误差的原因，探讨了合理的生产勘探方法及勘探网度，分析并划分了合理的勘探类型，为类似矿床的勘探、开发提供借鉴。     

动筛跳汰机及其应用

动筛跳汰机是近年来研制的用于分选25(13)~400mm粒级原煤的块煤分选设备,按驱动装置分为液压驱动式和机械驱动式两大类,处理量为50~350t/h,是目前国内选煤行业的最新产品之一。笔者认为,该设备在今后的煤炭洗选加工中具有广阔的应用和推广前景。     

煤炭企业发展循环经济的路径研究

我国煤炭企业传统的“大量生产、大量消费、大量废弃”的模式,存在着许多严重问题,如环境污染、煤炭资源的产出率低、利用率低、回收率低等。长此以往,煤炭企业将面临资源枯竭、无煤可采的局面,将无法满足我国经济又好又快的发展需求。因此,煤炭企业发展循环经济是大势所趋,势在必行。文章主要分析了煤炭企业发展循环经济的必要性,并对煤炭企业发展循环经济的路径问题进行了较深入地探讨。     

回归方程在煤灰成分分析数理统计中的应用

在煤灰成分分析检测项目中有一些通常采用光电比色法进行检验.为了提高数据处理的准确度,采用一元线性回归方程对数据进行数理统计的方法,建立简单的数学模型,可快速、准确地获得计算结果.     

可控变流器的谐波抑制与MATLAB仿真

电力电子装置产生的谐波已成为电力系统的主要谐波污染源。对带直流电动机负载的可控变流器进行谐波分析,得出结论:三相桥式相控整流电路相当于一个包含高次谐波的电流谐波源。提出了相应的谐波抑制策略。用Matlab/Simulink软件包建立仿真模型,给出实验结果。仿真结果表明措施是可行的。     

金堆城低品位辉钼矿的可浸性

采用细菌和化学浸出方法研究金堆城低品位辉钼矿的可浸性。结果表明，酸性（硫酸）介质下的细菌氧化浸出和化学氧化浸出，钼易与一些金属离子（如Fe，Ca，Al）生成不溶性的化合物，钼浸出率很低。低浓度次氯酸钠（NaClO）氧化浸出工艺回收低品位辉钼矿的钼是可行的。保持浸液pH=9～11，有效氯浓度15g／L的NaClO能有效浸出钼.