企业专网号码的合理编制

号码是一种有限的资源,虽然企业专网的号码资源比较丰富,但也不能毫无规律随意编制,否则会为将来发展带来意想不到的麻烦,本文叙述了号码编制必须遵循的一些原则,希望对专网的管理人员有一些帮助。     

If Virchow and Ehrlich Had Dreamt Together: What the Future Holds for KRAS-Mutant Lung Cancer

Non-small-cell lung cancer (NSCLC) with Kirsten rat sarcoma (KRAS) mutations has notoriously challenged oncologists and researchers for three notable reasons: (1) the historical assumption that KRAS is “undruggable”, (2) the disease heterogeneity and (3) the shaping of the tumor microenvironment by KRAS downstream effector functions. Better insights into KRAS structural biochemistry allowed researchers to develop direct KRAS(G12C) inhibitors, which have shown early signs of clinical activity in NSCLC patients and have recently led to an FDA breakthrough designation for AMG-510. Following the approval of immune checkpoint inhibitors for PDL1-positive NSCLC, this could fuel yet another major paradigm shift in the treatment of advanced lung cancer. Here, we review advances in our understanding of the biology of direct KRAS inhibition and project future opportunities and challenges of dual KRAS and immune checkpoint inhibition. This strategy is supported by preclinical models which show that KRAS(G12C) inhibitors can turn some immunologically “cold” tumors into “hot” ones and therefore could benefit patients whose tumors harbor subtype-defining STK11/LKB1 co-mutations. Forty years after the discovery of KRAS as a transforming oncogene, we are on the verge of approval of the first KRAS-targeted drug combinations, thus therapeutically unifying Paul Ehrlich’s century-old “magic bullet” vision with Rudolf Virchow’s cancer inflammation theory.     

Figure of merit for environmental SEM and its implications

A recently introduced figure of merit for environmental and low vacuum scanning electron microscopes has now been computed in the full operational pressure range for one commercial instrument. The direct simulation Monte Carlo method has been used in lieu of experimental measurements. The theory of this figure of merit is further consolidated. It is shown that a thin pressure limiting aperture can indeed be used as an optimum reference system for all instruments employing differential pumping in the transfer of an electron beam from high vacuum to high pressure. The implications of the results obtained are discussed both in relation to existing commercial instruments and associated literature to pave the way for future progress in the field.     

Territorial targeting in EU private law

In a series of rulings given in the last few years, the Court of Justice of the European Union (EU) has made use of the concept of targeting by a trader of a particular territorial market as a device for determining the scope of European legislation on private law. The concept is of particular importance in the context of trading activities conducted by means of the Internet, though its significance is not confined to such activities. In particular, the European Court has used the concept of targeting for the purpose of restricting the substantive ambit of intellectual property rights created or harmonised by EU legislation. On the other hand, it has avoided use of the concept of targeting in the context of EU legislation allocating jurisdiction between the courts of the Member States, even in respect of disputes involving intellectual property, except where a legislative text specifically invokes such a concept. The instant paper endeavours to review the position as currently established by the European case-law, and to predict the likely further developments.     

信息处理用维语词汇标注标记集的确定

介绍了研究和制定信息处理用维语标注标记集的研究进展。讨论了研究与制订“维语标注标记集”必要性,说明了只靠语法角度提出的词汇一级“维语标注标记集”的有限性,论述国内外英语、汉语层次分析研究的最新成果,结合维语的本身特点研究维语语义分类体系迫切性,给出了“维语标注标记集”的工作思路、标记集制定的原则和语法语义词汇一级词性标记集的内容,比较了标记集两个版本的特点,展望了其发展。     

基于3D-Zernike的三维弹痕特征提取技术

本文首次针对三维弹痕数据的三维拓扑结构特性的描述问题,提出基于3D-Zernike的三维特征提取方法。充分利用3D-Zernike描述子的平移,尺度,旋转不变性,信息表达的高效性,面向真实三维弹痕数据进行分析和比较。实验验证了该特征对于三维弹痕数据描述的有效性,3D-Zernike描述子对弹痕的次棱数据的描述表现出很好的同一性和差异性。     

基于开关磁阻电机消除织机开车痕的控制系统

根据织机的负载情况,设计了一套开关磁阻电机的控制系统,并选用3.5 kW电机进行转矩过载倍数的核算.经试验和分析,开关磁阻电机以其较大的起动转矩,可以有效解决织机因第一纬打纬力不足造成的开车痕问题.     

新型基因枪微弹材料可行性初步研究-Ⅰ

基因枪在未来临床基因转导中很有前途,但目前所用微弹材料金、钨都属于重金属,其长期存在于人体的安全性尚无法估计。提出用羟基磷灰石(HAP)微粒来代替金或钨微粒,从理论上推导了这种取代的可行性,并报告了一种HAP微粒的制备及其负载DNA的研究结果。理论推导完全按照物理学方法进行。实验部分的方法:将稳定剂H以一定速度和比例滴入一定浓度的Ca(H2PO4)2溶液中,再按照一定的速度和比例滴入Ca(OH)2饱和溶液,期间或完成后超声处理一定时间,将所得HAP微粒溶液与亚精胺和DNA以一定比例和浓度在一定pH条件下混合。结论:所得HAP粒径值符合要求,并且能够高效负载DNA。     

利用CCD实测数据恢复弹形的方法

根据线阵CCD的工作特性,通过对弹丸CCD试验数据进行分析,提出了一种完整的弹丸图像恢复方法,包括阈值法提取数据、二维自适应除噪滤波、样条函数曲线拟合、微分边缘识别等。应用表明该方法具有简单、稳定、可靠、精度高的特点,在弹形恢复中取得了满意的结果,为测定弹丸飞行参数奠定了基础。     

Damage Detection Utilizing the Damage Index Method to a Benchmark Structure

This paper addresses the first generation benchmark problem on structural health monitoring developed by the ASCE Task Group on Structural Health Monitoring. The focus of the problem is a four-story model of an existing physical model at the University of British Columbia where simulated data are used for the system identification. Modal parameters were extracted using the frequency domain decomposition method. Rather than relying on data from the undamaged structure, a new proposed methodology based on ratios between stiffness and mass values from the eigenvalue problem is presented to identify the undamaged state of the structure. Once the structural identification is complete, the damage index method is used to detect the location and severity of damage. By not relying on undamaged structure information, this approach may be applicable to existing structures that may already incorporate some amount of damage.