Modeling Effects of Rhythmic Context on Perceived Duration: A Comparison of Interval and Entrainment Approaches to Short-Interval Timing.

Relative merits of interval and entrainment conceptions of the internal clock were assessed within a common theoretical framework by 4 time-judgment experiments. The timing of tone onsets marking the beginning and ending of standard and comparison time intervals relative to a context rhythm were manipulated: onsets were on time, early, or late relative to the implied rhythm, and 2 distinct accuracy patterns emerged. A quadratic ending profile indicated best performance when the standard ended on time and worst performance when it was early or late, whereas a flat beginning profile (Experiments 1-3) indicated uniform performance for the 3 expectancy conditions. Only in Experiment 4, in which deviations from expected onset times were large, did significant effects of beginning times appear in time-discrimination thresholds and points of subjective equality. Findings are discussed in the context of theoretical assumptions about clock resetting, the representation of time, and independence of successive time intervals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sensitivity of the retinal pigment epithelium to spindle poisons

PURPOSE: The function of RPE is well known in PVR. Pharmacological agents have been extensively studied both experimentally and clinically. Few reports have detailed the interactions of antimitotic drugs on the microtubule network. The aim of this study is to visualize by indirect immunofluorescence the effects of colchicine and paclitaxel on the microtubule network of cultured pig RPE cells in interphase. METHODS: Pigs were killed at the slaughter-house, their eyes were enucleated. RPE cells were isolated and cultured. RPE cells were plated onto glass cover-slips at a density of 2,000,000 cells/ml, cultured and treated with the drugs during 4 and 24 hours at 37 degrees C at different concentrations. Immunofluorescence reaction was developped using antitubulin and fluoresceinated anti-mouse antibodies. The cytoskeletons were visualized employing a Zeiss photomicroscope equipped with epiilumination, a 63 x lens and appropriate filters for fluoresceine. RESULTS: The cytoplasmic microtubules of RPE cells were disrupted in a concentration and time-dependant manner by colchicine. Between 10 and 100 nm Veveral degrees of depolymarization of the microtubule network were observed. Paclitaxel between 1 micron and 10 microns was found to induce several degrees of microtubule "bundling" after 4 and 24 hours of incubation. Actin network was modified neither by colchicine and paclitaxel used in the same conditions. CONCLUSIONS: The results show that low doses of antimitotic drugs inhibit the microtubule network formation by depolymerization (colchicine) or stabilize it (paclitaxel). These actions inhibit cell division, which is one of the mechanisms implicated in PVR.     

Wind tunnel-based testing of a photoelectrochemical oxidative filter-based air purification unit in coronavirus and influenza aerosol removal and inactivation

Recirculating air purification technologies are employed as potential means of reducing exposure to aerosol particles and airborne viruses. Toward improved testing of recirculating air purification units, we developed and applied a medium-scale single-pass wind tunnel test to examine the size-dependent collection of particles and the collection and inactivation of viable bovine coronavirus (BCoV, a betacoronavirus), porcine respiratory coronavirus (PRCV, an alphacoronavirus), and influenza A virus (IAV), by a commercial air purification unit. The tested unit, the Molekule Air Mini, incorporates a MERV 16 filter as well as a photoelectrochemical oxidating layer. It was found to have a collection efficiency above 95.8% for all tested particle diameters and flow rates, with collection efficiencies above 99% for supermicrometer particles with the minimum collection efficiency for particles smaller than 100 nm. For all three tested viruses, the physical tracer-based log reduction was near 2.0 (99% removal). Conversely, the viable virus log reductions were found to be near 4.0 for IAV, 3.0 for BCoV, and 2.5 for PRCV, suggesting additional inactivation in a virus family- and genus-specific manner. In total, this work describes a suite of test methods which can be used to rigorously evaluate the efficacy of recirculating air purification technologies.     

Durability of CFRP cables exposed to simulated concrete environments

One of the main causes of structural deficiency in concrete bridges is the deterioration of the constituent materials. Some transportation agencies have started exploring the use of carbon fiber reinforced polymers (CFRP) as a corrosion-resistant alternative to steel prestressing materials for longer lasting concrete bridge structures. To implement CFRP in prestressed concrete bridge structures with more confidence, an understanding of the challenges pertaining to durability under in-service environmental conditions is essential. This paper explores the effects of temperature with alkaline and alkaline/chloride solutions on material properties over time, in the context of reinforced and prestressed concrete structures for transportation applications. The durability testing yielded several key findings: (1) higher temperatures accelerate degradation, (2) moisture sorption was the primary process responsible for the observed degradation, with plasticization and microcracking as the controlling mechanisms leading to fiber–matrix interfacial debonding, and (3) a relaxation-based analytical model was implemented to predict residual properties after environmental exposure, showing promising agreement with experimental data.     

Impulse Control for Planar Spring-Mass Running

In this paper, we present a novel control strategy for running which is robust to disturbances, and makes excellent use of passive dynamics for energy economy. Our strategy combines two ideas: an existing flight phase policy, and a novel stance phase impulse control policy. The state-of-the-art flight phase policy commands a leg angle trajectory that results in a consistent horizontal center-of-mass velocity from hop to hop when running over uneven terrain, thus maintaining a steady gait and avoiding falls. Our novel stance phase control policy rejects ground disturbances by matching the actuated model’s toe impulse profile to that of a passive spring-mass system hopping on flat rigid ground. This combined strategy is self-stable for changes in ground impedance or ground height, and thus does not require a ground model. Our strategy is promising for robotics applications, because there is a clear distinction between the passive dynamic behavior of the model and the active controller, it does not require sensing of the environment, and it is based on a sound theoretical background that is compatible with existing high-level controllers for ideal spring-mass models.     

The study of the influence of wear of the cutting tool with an insert of cBN-based composite material on the tool vibrations in finish turning of hardened steels

It has been found out that wear of a cutting tool with an insert of cBN-based composite material has an effect on the tool vibrations in finish turning of hardened steels with various hardness values. The influence of the tool vibrations on the machined surface roughness has been studied.     

Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review

Autophagy is a complex process involved in several cell activities, including tissue growth, differentiation, metabolic modulation, and cancer development. In prostate cancer, autophagy has a pivotal role in the regulation of apoptosis and disease progression. Several molecular pathways are involved, including PI3K/AKT/mTOR. However, depending on the cellular context, autophagy may play either a detrimental or a protective role in prostate cancer. For this purpose, current evidence has investigated how autophagy interacts within these complex interactions. In this article, we discuss novel findings about autophagic machinery in order to better understand the therapeutic response and the chemotherapy resistance of prostate cancer. Autophagic-modulation drugs have been employed in clinical trials to regulate autophagy, aiming to improve the response to chemotherapy or to anti-cancer treatments. Furthermore, the genetic signature of autophagy has been found to have a potential means to stratify prostate cancer aggressiveness. Unfortunately, stronger evidence is needed to better understand this field, and the application of these findings in clinical practice still remains poorly feasible.     

Environmental and operational stability of solution-processed 6,13-bis(triisopropyl-silylethynyl) pentacene thin film transistors

We report operational and environmental stability of solution-processed organic thin film transistors (OTFTs) using the small molecule organic semiconductor 6,13-bis(triisopropyl-silylethynyl) pentacene (TIPS-pentacene). Typical drop-cast TIPS-pentacene OTFTs show strong molecular ordering and relatively stable characteristics with air and illumination compared to vapor-deposited pentacene OTFTs. For short channel length devices, TIPS-pentacene OTFTs undergo significant degradation with bias-stress, possibly due to operation at large drive currents and large local power dissipation as well as built-in charges in the channel area.