Measurement of neonatal responses to painful stimuli: a research review

The measurement of neonatal responses to painful stimuli remains a significant clinical problem. Although numerous measures have been evaluated, instruments that are valid, reliable, and clinically feasible are not yet available. The purpose of this paper is to critique the studies that have been done using biochemical, physiological, and behavioral measures to evaluate neonatal responses to painful stimuli. Specific issues regarding measurement in premature and critically ill neonates are emphasized. The intent of this review and critique of the literature is to stimulate additional research into the assessment of neonatal pain.     

Prebiotic synthesis of sequential peptides on the Hadean beach by a molecular engine working with nitrogen oxides as energy sources

Addressing the still open question of the prebiotic origin of sequential macromolecules (peptides, nucleic acids) on the primitive Earth, we describe a molecular engine (the primary pump), which works at ambient temperature and continuously generates, elongates and complexifies sequential peptides. This new scenario is based on a cyclic reaction sequence, whose keystep is the activation of amino acids into their N‐carboxyanhydrides (NCA) through nitrosation by NOx. This process could have taken place on tidal beaches; it requires a buffered ocean, emerged land and a nitrosating atmosphere. With the help of geochemical studies and computer simulations of atmosphere photochemistry, we show that the primitive Earth during the Hadean may have satisfied all these requirements. © 2001 Society of Chemical Industry.     

European medical schools and tobacco

Following a survey in 19 European countries of the habits, attitudes and knowledge of medical students regarding tobacco, World Health Organisation European Office and the International Union against Tuberculosis and Lung Disease jointly circulated to the Deans of all European medical schools a summary of the results, including figures for mortality for smoking-related diseases in their countries and a brief questionnaire concerning faculty action on the tobacco problem. The response rate was just over 50%, higher in Northern Europe (66%) than in Southern (35%) or Eastern (38%). Only 8% of faculties had a specific teaching module on tobacco. In most it was either systematically (35%) or unsystematically (55%) integrated in other teaching. Teaching hospitals, teaching areas and faculty meetings were said to be smokefree by over 90%; figures were lower for other areas. Seventy-seven per cent of Deans intended to discuss our approach with their teaching staff; 72% gave the name of a staff member with a particular tobacco interest.     

Blocage par injection de modes sous- harmoniques d’un oscillateur utilisant une ligne à retard à ondes de surface

A nonlinear regeneration pulsed oscillator driven by a monochromatic source has been built. Subharmonics of the resonance carrier/modulation are measured with an accuracy of 10^-10 thanks to the use of a double beats measurement set-up. The multiscale analysis of frequency readings reveals a rich fine structure which is in agreement with the nonlinear topological approach of synchronized states.     

Correlation between He-Ne scatter and 2.7-microm pulsed laser damage at coating defects

A reported correlation between defect-initiated pulsed laser damage and local predamage scatter in multilayer infrared mirror coatings has been analyzed in detail. Examination of a much larger data base confirms the previous result on dielectric-enhanced reflectors with polished substrates over a wide range of energy densities above the damage onset. Scatter signals from individual undamaged defects were detected using a He-Ne scatter probe with a focal spot that nearly coincides with the 150-microm-diam (D1/e(2)) focal spot of the damage-probe beam. Subsequent damage frequency measurements (1-on-1) were made near normal or at 45 degrees incidence with 100-ns pulses at 2.7-microm wavelength. The correlation is characterized by an increase in damage frequency with increasing predamage scatter signal and by equivalence of the defect densities indicated by the two probes. Characteristics of the correlation are compared with a simple model based on focal spot intensity profiles. Conditions that limit correlation are discussed, including variable scatter from defects and background scatter from diamond-turned substrates. Results have implication for nondestructive defect detection and coating quality control.     

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (HCy)-lowering therapy does not affect the inflammatory state of CVD patients, and it has little influence on cardiovascular risk. The HCy degradation product hydrogen sulfide (H₂S) is a cardioprotector. Previous research proposed a positive role of H₂S in the cardiovascular system, and we discuss some recent data suggesting that HHCy worsens CVD by increasing the production of H₂S, which decreases the expression of adenosine A_2A receptors on the surface of immune and cardiovascular cells to cause inflammation and ischemia, respectively.     

Feature extraction of the first difference of EMG time series for EMG pattern recognition

This paper demonstrates the utility of a differencing technique to transform surface EMG signals measured during both static and dynamic contractions such that they become more stationary. The technique was evaluated by three stationarity tests consisting of the variation of two statistical properties, i.e., mean and standard deviation, and the reverse arrangements test. As a result of the proposed technique, the first difference of EMG time series became more stationary compared to the original measured signal. Based on this finding, the performance of time-domain features extracted from raw and transformed EMG was investigated via an EMG classification problem (i.e., eight dynamic motions and four EMG channels) on data from 18 subjects. The results show that the classification accuracies of all features extracted from the transformed signals were higher than features extracted from the original signals for six different classifiers including quadratic discriminant analysis. On average, the proposed differencing technique improved classification accuracies by 2–8%.     

The problem of correction for ohmic potential drop in linear potential sweep experiments and the derivation of s0 values for electrode surface processes

Rate constants or exchange current densities of electrode surface processes involving adatom arrays are conveniently evaluated by determining that sweep rate, s₀ (the reversibility parameter), in a linear potential sweep (LPS) experiment, below which the process just remains kinetically reversible, ie its overpotential is sensibly zero. Transition to irreversibility is characterized by peak potentials, E_p, becoming linear in the log of the sweep rate, s, following a region of independence of s for < s₀. A suitable extrapolation procedure enables s₀ to be evaluated. However, if s₀ is large and/or the resistivity of the solution is appreciable, the IR_u drop associated with uncompensated resistance in the measurement system can be comparable with the increase of E_p with log s, when s > s₀, rendering evaluation of s₀ inaccurate. While compensation or empirical correction for this may be made, it is desirable that the nature of the IR_u effect of the LPS I vs E profiles be understood in a more fundamental way. It is the purpose of this communication to provide such a treatment of this effect through evaluation of the actual time-dependent potential that becomes applied to the electrode, and to propose criteria based on the product of s₀, R_u and the reaction pseudocapacitance, C_φ for indicating the anticipated extent of the IR_u effect in the evaluation of s₀. While the transition in the E_p vs log s plot may be due to IR_u effects as well as to kinetic irreversibility, when the former are appreciable, it is shown that the corresponding transition in the value of C_φ with increasing log s can usually allow spurious IR_u and significant irreversibility effects to be distinguished.     

Ontology-based feature mapping and verification between CAD systems

Data interoperability between computer-aided design (CAD) systems remains a major obstacle in the information integration and exchange in a collaborative engineering environment. The use of CAD data exchange standards causes the loss of design intent such as construction history, features, parameters, and constraints, whereas existing research on feature-based data exchange only focuses on class-level feature definitions and does not support instance-level verification, which causes ambiguity in data exchange. In this paper, a hybrid ontology approach is proposed to allow for the full exchange of both feature definition semantics and geometric construction data. A shared base ontology is used to convey the most fundamental elements of CAD systems for geometry and topology, which is to both maximize flexibility and minimize information loss. A three-branch hybrid CAD feature model that includes feature operation information at the boundary representation level is constructed. Instance-level feature information in the form of the base ontology is then translated to local ontologies of individual CAD systems during the rule-based mapping and verification process. A combination of the Ontology Web Language (OWL) and Semantic Web Rule Language (SWRL) is used to represent feature classes and properties and automatically classify them by a reasoner in the target system, which requires no knowledge about the source system.     

A particle‐based moving interface method (PMIM) for modeling the large deformation of boundaries in soft matter systems

The mechanics of the interaction between a fluid and a soft interface undergoing large deformations appear in many places, such as in biological systems or industrial processes. We present an Eulerian approach that describes the mechanics of an interface and its interactions with a surrounding fluid via the so‐called Navier boundary condition. The interface is modeled as a curvilinear surface with arbitrary mechanical properties across which discontinuities in pressure and tangential fluid velocity can be accounted for using a modified version of the extended finite element method. The coupling between the interface and the fluid is enforced through the use of Lagrange multipliers. The tracking and evolution of the interface are then handled in a Lagrangian step with the grid‐based particle method. We show that this method is ideal to describe large membrane deformations and Navier boundary conditions on the interface with velocity/pressure discontinuities. The validity of the model is assessed by evaluating the numerical convergence for a axisymmetrical flow past a spherical capsule with various surface properties. We show the effect of slip length on the shear flow past a two‐dimensional capsule and simulate the compression of an elastic membrane lying on a viscous fluid substrate. Copyright © 2015 John Wiley & Sons, Ltd.