Fluoroelastomers-dependence of relaxation phenomena on composition

The dynamic-mechanical properties of some fluoroelastomers were determined as a function of composition at low frequency (≈ 1 Hz), by means of a free oscillation torsion pendulum, between −180°C and the softening point. Vinylidenefluoride (VDF)-hexafluoropropene (HFP) copolymers of molar composition 0–39% HFP and terpolymers of VDF and HFP with up to 30mol% tetrafluoroethylene (TFE) and a constant VDF to HFP molar ratio of 3.4 were considered. Two relaxation processes typical of the amorphous phase were found. The first, located at about −87°C, is related to local motions and the transition temperature was found to be independent of composition for copolymers, while it depends on TFE molar content for terpolymers. The second is related to the glass transition and the transition temperature depends on the composition. However, for semicrystalline copolymers the double glass transition phenomenon was observed. When crystallinity goes to zero at about 20 mol% HFP, only one transition is observed. It was also found that ordered structures can take place for terpolymers when TFE molar concentration exceeds 20%. The crystal disorder transition of pure PVDF (75°C) is observed also for low HFP concentrations but the transition temperature is strongly reduced. Analogies between the VDF-HFP and E-P systems are also discussed.     

Investigation of the biogenetic reaction sequence of cholesterol in rat tissues,through inhibition with AY-9944

An inhibitor of Δ⁷-reductase, AY-9944 (trans-1,4-bis(2-dichlorobenzylaminomethyl cyclohexane dihydrochloride), was used to investigate the last steps of cholesterol formation in brain and liver of adult and newborn rats. The accumulation of different sterols in the two tissues of the same animals was observed. Δ^5,7-Cholestadien-3β-ol, Δ^7,24-cholestadien-3β-ol and Δ^5,7,24-cholestatrien-3β-ol, which are not present in detectable amounts in control brains, were identified in brains of growing rats treated with AY-9944. An accumulation of Δ^5,7-cholestadien-3β-ol only was found in adult rat tissues. These differences in sterol accumulation are discussed in relation with the possible in vivo pathways of cholesterol biosynthesis.     

Real-time inverse dynamics control of parallel manipulators using general-purpose multibody software

This work deals with the problem of computing the inverse dynamics of complex constrained mechanical systems for real-time control applications. The main goal is the control of robotic systems using model-based schemes in which the inverse model itself is obtained using a general purpose multibody software, exploiting the redundant coordinate formalism. The resulting control scheme is essentially equivalent to a classical computed torque control, commonly used in robotics applications. This work proposes to use modern general-purpose multibody software to compute the inverse dynamics of complex rigid mechanisms in an efficient way, so that it suits the requirements of realistic real-time applications as well. This task can be very difficult, since it involves a higher number of equations than the relative coordinates approach. The latter is believed to be less general, and may suffer from topology limitations. The use of specialized linear algebra solvers makes this kind of control algorithms usable in real-time for mechanism models of realistic complexity. Numerical results from the simulation of practical applications are presented, consisting in a “delta” robot and a bio-mimetic 11 degrees of freedom manipulator controlled using the same software and the same algorithm.     

Changes in vitro of the electrolyte content and erythrocyte volume of the venous blood of patients with chronic pneumopathy subjected to tonometry in oxygen]

As previously observed in vivo, statistically significant variations characterized by increase in chlorine and diminution in sodium, associated with an increase in red cell volume, have been noted in vitro in samples of venous blood taken from patients undergoing tonometry under oxygen. These variations appear to be independent of the basic concentration of chlorine and do not occur if the blood samples are incubated with theophylline at the same time. These results confirm the hypothesis of a "non respiratory" plasmatic acidifying effect of oxygen therapy inhibited by the antiphosphodiesterasic action of theophylline.     

Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice

The neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been proposed to be attenuated by sequestration into intracellular vesicles by the vesicular monoamine transporter (VMAT2). The purpose of this study was to determine if mice with genetically reduced levels of VMAT2 (heterozygote knockout; VMAT2 +/-) were more vulnerable to MPTP. Striatal dopamine (DA) content, the levels of DA transporter (DAT) protein, and the expression of glial fibrillary acidic protein (GFAP) mRNA, a marker of gliosis, were assessed as markers of MPTP neurotoxicity. In all parameters measured VMAT2 +/- mice were more sensitive than their wild-type littermates (VMAT2 +/+). Administration of MPTP (7.5, 15, or 30 mg/kg, b.i.d.) resulted in dose-dependent reductions in striatal DA levels in both VMAT2 +/- and VMAT2 +/+ animals, but the neurotoxic potency of MPTP was approximately doubled in the VMAT2 +/- mice: 59 versus 23% DA loss 7 days after 7.5 mg/kg dose for VMAT2 +/- and VMAT2 +/+ mice, respectively. Dopaminergic nerve terminal integrity, as assessed by DAT protein expression, also revealed more drastic reductions in the VMAT2 +/- mice: 59 versus 35% loss at 7.5 mg/kg and 95 versus 58% loss at 15 mg/kg for VMAT2 +/- and VMAT2 +/+ mice, respectively. Expression of GFAP mRNA 2 days after MPTP was higher in the VMAT2 +/- mice than in the wild-type: 15.8- versus 7.8-fold increase at 7.5 mg/kg and 20.1- versus 9.6-fold at 15 mg/kg for VMAT2 +/- and VMAT2 +/+ mice, respectively. These observations clearly demonstrate that VMAT2 +/- mice are more susceptible to the neurotoxic effects of MPTP, suggesting that VMAT2-mediated sequestration of the neurotoxin into vesicles may play an important role in attenuating MPTP toxicity in vivo.     

Cooperative and Reliable ARQ Protocols for Energy Harvesting Wireless Sensor Nodes

One class of wireless sensor networks makes use of sensor nodes that recharge their batteries by harvesting energy from the surrounding environment. Being continuously recharged, the battery does not need to be replaced regularly and the sensor node is maintenance-free. A key module in such sensor network solutions is the data link automatic repeat request (ARQ) protocol, which must be designed to reliably deliver sensor nodes data at the minimum energy cost. With this objective in mind, two ARQ protocol classes are compared. In one class, each sensor node operates individually. In the other, the concept of cooperative communications is adopted, whereby neighboring sensor nodes help each other during the retransmission process. It is shown that the use of cooperative ARQ protocols in energy harvesting sensor networks enables sensor nodes to balance their energy consumption to match their own battery recharge rate. In turn, a balanced energy consumption-to-recharge rate ratio has the potential to improve the network throughput. Both classes of ARQ protocols are analyzed and compared. Estimated throughput gains are discussed under various network scenarios.     

Suitability of 3,4-dialkyl substitution in molecular crystal based on thiophene–fluorenone for organic field effect transistors

A new co-oligomer constituted by both a thiophene sequence bearing a 3,4-dialkyl substitution, imparting processability, and by end-capping fluorenone moieties, has been synthesised. The molecule, potentially suitable for close-packing aptness, has been characterized by means of combined optical, thermal, structural, and morphological analyses, showing that, despite the O–H intermolecular interaction favoured by fluorenone presence, the large steric hindrance specific to the dialkyl 3,4-disubstitution strongly limits the intermolecular interaction. Hence it makes such substitution pattern unsuitable for field effect transistor application, as it is confirmed by the electrical performances measured on prototype devices.     

Phase-II randomized study of pre-operative IL-2 administration in operable NSCLC

In recent years, the Th1/Th2 concept has become of prime importance in the understanding of heterogeneous responses of the immune system and implications thereof for infectious and autoimmune diseases. Originally established on the basis of different cytokines produced by T cell clones, it is now known that the Th1/Th2 concept really defines totally different immune pathways that affect most if not all cells of the immune system. Murine experimental leishmaniasis was the first model to confirm the relevance of the Th1/Th2 concept in vivo. Herein, we summarize the current knowledge on the characteristics and generation of Th1 and Th2 cells, as well as on recent advances of the application of this concept to murine cutaneous leishmaniasis.