STRONG METAL-CERAMIC JOINTS

In this paper the technology for joining metals to ceramics is reviewed. The technologies of metal powder sintering, liquid phase joining with activated brazing alloys and with ceramic frit, solid-state joining, friction welding and mechanical fixation are described. In order to put some perspective on the mechanical data given in the literature, some evaluating remarks on mechanical testing are made.     

Sequence annotation of nuclear receptor ligand-binding domains by automated homology modeling

The quality of three-dimensional homology models derived fromprotein sequences provides an independent measure of the suitabilityof a protein sequence for a certain fold. We have used automatedhomology modeling and model assessment tools to identify putativenuclear hormone receptor ligand-binding domains in the genomeof Caenorhabditis elegans. Our results indicate that the availabilityof multiple crystal structures is crucial to obtaining usefulmodels in this receptor family. The majority of annotated mammaliannuclear hormone receptors could be assigned to a ligand-bindingdomain fold by using the best model derived from any of fourtemplate structures. This strategy also assigned the ligand-bindingdomain fold to a number of C.elegans sequences without priorannotation. Interestingly, the retinoic acid receptor crystalstructure contributed most to the number of sequences that couldbe assigned to a ligand-binding domain fold. Several causesfor this can be suggested, including the high quality of thisprotein structure in terms of our assessment tools, similaritybetween the biological function or ligand of this receptor andthe modeled genes and gene duplication in C.elegans.     

The copper chaperone for superoxide dismutase

Copper is distributed to distinct localizations in the cell through diverse pathways. We demonstrate here that the delivery of copper to copper/zinc superoxide dismutase (SOD1) is mediated through a soluble factor identified as Saccharomyces cerevisiae LYS7 and human CCS (copper chaperone for SOD). This factor is specific for SOD1 and does not deliver copper to proteins in the mitochondria, nucleus, or secretory pathway. Yeast cells containing a lys7Delta null mutation have normal levels of SOD1 protein, but fail to incorporate copper into SOD1, which is therefore devoid of superoxide scavenging activity. LYS7 and CCS specifically restore the biosynthesis of holoSOD1 in vivo. Elucidation of the CCS copper delivery pathway may permit development of novel therapeutic approaches to human diseases that involve SOD1, including amyotrophic lateral sclerosis.     

Measurement of T1 and T2 relaxation times of the pancreas at 7 T using a multi-transmit system

Objective

To determine T₁ and T₂ relaxation times of healthy pancreas parenchyma at 7 T using a multi-transmit system.

Materials and methods

Twenty-six healthy subjects were scanned with a 7 T MR system using eight parallel transceiver antennas, each with two additional receive loops. A Look-Locker sequence was used to obtain images for T₁ determination, while T₂ was obtained from spin-echo images and magnetic resonance spectroscopy measurements with different echo times. T₁ and T₂ times were calculated using a mono-exponential fit of the average magnitude signal from a region of interest in the pancreas and were tested for correlation with age.

Results

The age range of the included subjects was 21–72 years. Average T₁ and T₂ relaxation times in healthy pancreas were 896 ± 149 ms, and 26.7 ± 5.3 ms, respectively. No correlation with age was found.

Conclusion

T₁ and T₂ relaxation times of the healthy pancreas were reported for 7 T, which can be used for image acquisition optimization. No significant correlations were found between age and T₁ or T₂ relaxation times of the pancreas. Considering their low standard deviation and no observable age dependence, these values may be used as a baseline to study potentially pancreatic tissue affected by disease.

     

Simulation-based evaluation of SAR and flip angle homogeneity for five transmit head arrays at 14 T

Introduction

Various research sites are pursuing 14 T MRI systems. However, both local SAR and RF transmit field inhomogeneity will increase. The aim of this simulation study is to investigate the trade-offs between peak local SAR and flip angle uniformity for five transmit coil array designs at 14 T in comparison to 7 T.

Methods

Investigated coil array designs are: 8 dipole antennas (8D), 16 dipole antennas (16D), 8 loop coils (8D), 16 loop coils (16L), 8 dipoles/8 loop coils (8D8L) and for reference 8 dipoles at 7 T. Both RF shimming and k_T-points were investigated by plotting L-curves of peak SAR levels vs flip angle homogeneity.

Results

For RF shimming, the 16L array performs best. For k_T-points, superior flip angle homogeneity is achieved at the expense of more power deposition, and the dipole arrays outperform the loop coil arrays.

Discussion and conclusion

For most arrays and regular imaging, the constraint on head SAR is reached before constraints on peak local SAR are violated. Furthermore, the different drive vectors in k_T-points alleviate strong peaks in local SAR. Flip angle inhomogeneity can be alleviated by k_T-points at the expense of larger power deposition. For k_T-points, the dipole arrays seem to outperform loop coil arrays.