Monolithic integration of spot-size converters with 1.3-μmlasers and 1.55-μm polarization insensitive semiconductor opticalamplifiers

To reduce packaging costs, it is necessary to use passive alignment between the laser diodes and optical fiber. Such an alignment requires low-coupling loss and large positional alignment tolerances. This is achievable with integrated spot-size converters, which permit to match the near field of a laser to that of a flat-end single-mode fiber (SMF). In this paper, we first review briefly the different technological approaches to realize spot-size converters. Then, we focus on the double-core structure developed both for 1.3-μm Fabry-Perot lasers and 1.55-μm semiconductor optical amplifiers (SOAs). The spot-size expansion is simulated using a two-dimensional (2-D) beam propagation method analysis. Short spot-size converters (100 μm) integrated with 1.3-μm lasers and 1.55-μm SOAs exhibit beam divergences as low as 12°×12° and 12°×15°, respectively. The performances of devices with integrated spot-size converters are reported and discussed. A 2-in wafer process is used thanks to the versatility of the double-core structure and its compatibility with buried ridge stripe technology     

Biological parameters in major depression: effects of paroxetine, viloxazine, moclobemide, and electroconvulsive therapy. Relation to early clinical outcome

Mammography, whilst remaining the first line imaging investigation of suspected primary breast cancer, can be difficult to interpret in patients with fibrous or dense breasts. Radionuclide imaging of the breast (scintimammography) has been suggested as an additional test. The aim of this study was to perform prospectively a comparison of the two techniques in a population with suspected breast cancer. Seventy such patients, mean age 54 years (range 57 years, 28-85) with 74 suspicious breast lesions were studied. They were imaged 5-10 min after intravenous injection of 740 MBq of Tc-99m sestamibi. Prone lateral and anterior supine views with and without markers were performed. All patients had histological confirmation of the nature of the breast lesions by limited incisional biopsy or definitive wide local excision, or cytological confirmation on fine needle aspiration. All patients had X-ray mammography. There were 53 malignant breast tumours and 21 benign lesions. Scintimammography correctly diagnosed 47 breast cancers, and yielded true-negative results in 12 benign breast lesions. There were six cases of false-negative results and nine false-positive results. Four scans were reported as equivocal. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 89%, 52%, 84% and 67%, respectively. X-ray mammography diagnosed correctly 37 malignant tumours, and in 12 benign lesions the results were true negatives. Ten studies were reported as equivocal. The sensitivity, specificity, PPV and NPV were 70%, 57%, 80% and 43%, respectively. The accuracy of Tc-99m sestamibi scintimammography was better than X-ray mammography though this was not significant (McNemar's test). Fewer equivocal results were obtained with scintimammography. Scintimammography may therefore have a role in the diagnosis of primary breast cancer when X-ray mammography is equivocal or unhelpful.     

Design rules for a low-chirp integrated DFB laser with an electroabsorption modulator

Feedback from the front facet of an integrated DFB laser with an electroabsorption modulator generates additional chirp to the single modulator. The reduction of the sensitivity to that feedback is in tradeoff relation with the external differential quantum efficiency and the single-mode yield. We introduce a figure-of-merit for the feedback sensitivity. It is obtained from the modeling of the small signal frequency modulation (FM). It indicates design rules for low-chirp and high-efficiency devices.