Evaluation of Fully-Integrated Switching Regulators for CMOS Process Technologies

This paper presents a feasible study of fully-integrated switching voltage regulators for power-optimized systems-on-chip (SoCs). In order to evaluate the power efficiency across a number of design variables, a compact macro-model of a regulator is created and validated. A key focus of the study is on the characteristics of the active and passive devices that are needed in order to maximize the efficiency of an on-chip regulator. With the macro-model, geometric programming is used to find the optimal characteristics for a given set of constraints such as load condition, process technology, and area. The achievable efficiencies for various current loads and across a range of technologies from 0.35-mum to 90-nm CMOS process are analyzed. The power efficiency is found to be strongly dependent on the inductor technology and over 70% efficiency is possible with advanced inductor technologies.     

Congenital pulmonary lymphangiectasis with chylothorax: a heterogeneous lymphatic vessel abnormality

We describe the generation of a new antipeptide antibody that binds to the centromeric region of human mitotic chromosomes. This antibody was raised against a synthetic peptide corresponding to the 481-493 amino acid sequence of the human CENP-B autoantigen. Immunofluorescence analysis revealed that this anti-CENP-B serum showed an identical pattern to the human CREST anticentromere autoantibody in both mitotic cells and interphase nuclei. Immunoblotting showed that this antibody reacts with the recombinant human CENP-B autoantigen, indicating that it is directed to the 80-kDa centromere polypeptide. We have used this serum to determine, by indirect immunofluorescence, whether CENP-B is conserved in different mammalian species. Surprisingly, the human antipeptide antibody does not react with the centromeric proteins of cultured mouse, hamster, or Indian muntjac cells. Because the CENP-B gene has been cloned in human and mouse, our results suggest that the CENP-B epitope used as an immunogen in this study is not ubiquitous in mammalian cells, and that we have most probably established a monospecific antibody to the human centromere.     

VALENCE: affective visualisation using EEG

VALENCE is an interactive visualisation controlled by live brainwave monitoring. We used a wireless EEG headset to monitor the player's alpha waves (an indicator of relaxation) and valence (an indicator of emotion or arousal). The game world is an emergent system of attractive and repulsive forces responding to EEG input.     

CD57+/CD28- T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile, ex vivo cytolytic activity and enhanced tendency to apoptosis

Protopolystoma (Monogenea, Polystomatidae) is strictly specific to the anuran amphibian genus Xenopus. The host group is characterised by a polyploid series in which chromosome numbers reflect diploid, tetraploid, octoploid and dodecaploid constitutions; the series is considered to have evolved through interspecies hybridisation and genome duplication. This study correlates information on host evolutionary relationships with patterns of parasite speciation and host specificity. Protopolystoma is restricted to one subgenus (Xenopus) with multiples of 36 chromosomes, and is absent from the subgenus Silurana (with multiples of 20 chromosomes). Molecular, biochemical and karyotype evidence distinguishes three subgroups within Xenopus. Representative species from each subgroup, Xenopus muelleri, Xenopus fraseri and Xenopus laevis, have been examined for polystomatid infection. Two species of Protopolystoma occur in each of these host species. In X. muelleri, the two Protopolystoma species reflect parasite co-speciation corresponding with the divergence of two sibling host species. Xenopus fraseri and X. laevis (both with 2n = 36 chromosomes) are implicated in the hybrid origin of two octoploid species, Xenopus wittei and Xenopus vestitus (both 2n = 72). The relationships of the Protopolystoma species in these Xenopus taxa reflect this presumed ancestry. Xenopus wittei carries two species of Protopolystoma, one shared with X. fraseri and the other shared with X. laevis. Xenopus vestitus carries a single species of Protopolystoma which is shared with X. laevis but there is no "heirloom" which reflects its hybrid origin involving X. fraseri. In addition to these shared parasite species which may reflect shared host genes, X. fraseri and X. laevis each carry separate species-specific Protopolystoma which do not occur in other Xenopus species even where there is evidence of common genetic information (as in the allopolyploid wittei and vestitus). This case study may be interpreted as indicating a powerful influence of host genetic factors on susceptibility to infection, host-specificity, and parasite speciation.     

FAO’s AVHRR-based Agricultural Stress Index System (ASIS) for global drought monitoring

Agricultural production is highly dependent on climate variability in many parts of the world. In particular, drought may severely reduce crop yields, potentially affecting food availability at local, regional, and global scales. The Food and Agriculture Organization of the United Nations (FAO) operates the Global Early Warning System (GIEWS), which monitors global food supply and demand. One of the key challenges is to obtain synoptic information on a recurrent and timely basis about drought-affected agricultural zones. This is needed to quickly identify areas requiring immediate attention. The Agricultural Stress Index System (ASIS), based on imagery from the Advanced Very High Resolution Radiometer (AVHRR) sensors on board the National Oceanic and Atmospheric Administration (NOAA) and Meteorological Operational Satellite (METOP) satellites, was specifically developed to meet this need. The system is based on a methodology developed by Rojas, Vrieling, and Rembold over the African continent. This approach has been modified and adapted to the global scale to produce an agricultural stress index (ASI) representing, per administrative unit, the percentage of cropland (or pasture) areas affected by drought over the growing season. The vegetation health index (VHI), based on normalized difference vegetation index (NDVI) and temperature anomalies, is used as a drought indicator. A fused time series of AVHRR data from METOP and NOAA was used to produce a consistent time series of VHI at 1 km resolution. Global phenology maps, indicating the number of growing seasons and their start and end dates, were derived from a multi-annual image set of SPOT-Vegetation (1999–2011). The VHI time series and phenology maps were then combined to produce the ASI for the years 1984 to the present. This allowed evaluation of the suitability of the ASIS to identify drought using historical reports and ancillary data. As a result of this analysis, ASIS was positively evaluated to support the FAO early warning system.     

Early design stage exploration of fixed-length block structured architectures

An important challenge concerning the design of future microprocessors is that current design methodologies are becoming impractical due to long simulation runs and due to the fact that chip layout considerations are not incorporated in early design stages. In this paper, we show that statistical modeling can be used to speed up the architectural simulations and is thus viable for early design stage explorations of new microarchitectures. In addition, we argue that processor layouts should be considered in early design stages in order to tackle the growing importance of interconnects in future technologies. In order to show the applicability of our methodology which combines statistical modeling and processor layout considerations in an early design stage, we have applied our method on a novel architectural paradigm, namely a fixed-length block structured architecture. A fixed-length block structured architecture is an answer to the scalability problem of current architectures. Two important factors prevent contemporary out-of-order architectures from being scalable to higher levels of parallelism in future deep-submicron technologies: the increased complexity and the growing domination of interconnect delays. In this paper, we show by using statistical modeling and processor layout considerations, that a fixed-length block structured architecture is a viable architectural paradigm for future microprocessors in future technologies thanks to the introduction of decentralization and a reduced register file pressure.     

Molecular characterization of Escherichia coli O157 contamination routes in a cattle slaughterhouse

In a cattle slaughterhouse, sampling was performed over a 1-week period to examine the prevalence and possible contamination routes of Escherichia coli O157. Each sampling day, swab samples were collected from the slaughterhouse environment before onset of slaughter, from the slaughterline, and from 20 successively slaughtered animals. Isolation of E. coli O157 consisted of a 6-hour enrichment followed by immunomagnetic separation and selective plating. From the 394 samples taken, 84 (21%) were positive for E. coli O157. Pulsed-field gel electrophoresis (PFGE) of collected isolates produced 26 different profiles, from which 5 PFGE profiles carried two or more Stx genes. The combination of PFGE profiles and Stx types resulted in 32 different E. coli O157 types. E. coli O157 was found in the slaughterhouse environment before the onset of slaughter. The first two sampling days, feces and carcasses were found negative. On the third sampling day, five fecal samples and four carcasses from animals negative in the feces were positive. Hide of the anal region and the shoulder were found positive every sampling day. The shoulder hide was more than twice as contaminated as the anal region hide. Typing of different isolates from a sample showed that frequently different E. coli O157 types were presented. On sampling days 1 and 2, types present in the environment and on the hides of the slaughtered animals differed. On the third sampling day, two dominant types were found in the environment (even before the onset of slaughter), as well as on the hides, feces, and carcasses. Although examined animals originated from different farms, one (two on day 3) dominant E. coli O157 type was present on their hides each sampling day. These data indicated that (i) the progress of contamination can differ from day to day within a slaughterhouse and (ii) contact between animals after the departure from the farm can have a large effect on the spread of E. coli O157 hide contamination.     

Porous,Sintered Glass‐Ceramics from Inorganic Polymers Based on Fayalite Slag

The present paper deals with the synthesis of porous, sintered glass‐ceramics obtained at temperatures below 1150°C, originating from inorganic polymers based on fayalite slag. Firing led to the evaporation of water, dehydroxylation, and oxidation of Fe²⁺ above 345°C. For heating >700°C, the Si–O stretching band shifted from the 1160 and 750 cm^?1 to the 1255 and 830 cm^?1 region, due to a structural reorganization of the amorphous phase, whereas Fe–O bands appeared at 550 cm^?1. The final microstructure consisted predominantly of an amorphous phase, hematite, and franklinite. The open porosity and compressive strength decreased and increased, respectively, as the firing temperature increased. The final values suggest properties comparable to that of structural lightweight concrete, still, the materials synthesized herein, are lighter, and made primarily from secondary resources.