Use of a modified non-rebreathing mask during upper intestinal endoscopy

BACKGROUND AND STUDY AIMS: Recently, attention has been drawn to the significant occurrence of respiratory and other complications during upper intestinal endoscopy. This prospective study was designed to compare the incidence and severity of oxygen desaturation when two different methods of oxygen delivery were used during elective oesophagogastroduodenoscopy. PATIENTS AND METHODS: After local medical ethics committee approval and written informed consent, one hundred patients undergoing elective oesophagogastroduodenoscopy were randomly allocated to receive supplemental oxygen at either four litres per minute via nasal specular or ten litres per minute through a specially modified non-rebreathing mask. Oxygen saturations during endoscopy facilitated by midazolam sedation were recorded, and non-parametric tests were used to compare the oxygen saturations in the two groups. RESULTS: The mean oxygen saturations were significantly better during the procedure for American Society of Anesthesiology (ASA) grade 2 and 3 patients who received oxygen with the modified mask than for those who received oxygen via nasal specular (98.6% vs. 97.0%, P = 0.004 for ASA grade 2 and 98.4% vs. 95.5, P = 0.006 for ASA grade 3). CONCLUSIONS: For ASA grade 2 and 3 patients, the modified non-rebreathing mask significantly improves oxygen saturations during upper intestinal endoscopy. This technique should be more widely used for patients at moderate and high risk.     

Leakage mitigation in NW FET using negative Schottky junction drain and its process variation analysis

Journal of Computational Electronics - In this work, a Schottky junction on the drain side employing low workfunction (WF) metal is proposed as a method to suppress the OFF-state leakage in...     

Dyeing cotton with reactive dyes under neutral conditions

This paper describes a new method to dye cotton with selected reactive dyes by long-liquor – or so-called 'exhaustion'– processes under neutral conditions. Particularly promising results were obtained with reactive dyes containing free vinyl sulphone residues. Although there are dyes on the market that contain free vinyl sulphone groups, for example, the Novacron C (Huntsman) range of dyes, many of this class contain 'blocked' vinyl sulphone residues; examples include sulphatoethylsulphone or chloroethylsulphone precursor groups, and these may be preactivated to the highly reactive vinyl sulphone form simply by a mild alkali treatment. After this activation, neutral, long-liquor dyeings can be carried out at the boil in the presence of electrolyte. This new dyeing method gave very good results in terms of overall fixation efficiency values, without the need for alkali additions.     

Reproducible Enhancement of Fluorescence by Bimetal Mediated Surface Plasmon Coupled Emission for Highly Sensitive Quantitative Diagnosis of Double‐Stranded DNA

Plasmonic enhancement of fluorescence from SYBR Green I conjugated with a double‐stranded DNA (dsDNA) amplicon is demonstrated on polymerase chain reaction (PCR) products. Theoretical computation leads to use of the bimetallic (Au 2 nm–Ag 50 nm) surface plasmons due to larger local fields (higher quality factors) than monometallic (Ag or Au) ones at both dye excitation and emission wavelengths simultaneously, optimizing fluorescence enhancement with surface plasmon coupled emission (SPCE). Two kinds of reverse Kretschmann configurations are used, which favor, in signal‐to‐noise ratio, a fluorescence assay that uses optically dense buffer such as blood plasma. The fluorescence enhancement (12.9 fold at maximum) with remarkably high reproducibility (coefficient of variation (CV) < 1%) is experimentally demonstrated. This facilitates credible quantitation of enhanced fluorescence, however unlikely to obtain by localized surface plasmons. The plasmon‐induced optical gain of 46 dB due to SPCE‐active dye molecules is also estimated. The fluorescence enhancement technologies with PCR enables LOD of the dsDNA template concentration of ≈400 fg µL^?1 (CV < 1%), the lowest ever reported in DNA fluorescence assay to date. SPCE also reduces photobleaching significantly. These technologies can be extended for a highly reproducible and sufficiently sensitive fluorescence assay with small volumes of analytes in multiplexed diagnostics.     

Renal pathologies in giant toads (Bufo marinus) vary with land use

A variety of human land uses involve the release of toxins into the environment. Wildlife live alongside humans across this array of land uses and thus, are exposed to varying chemical milieus. Kidneys are the principle excretory organs for vertebrates and excessive or chronic exposure to exogenous toxins can lead to renal pathology and renal failure. Although studies have linked chemical exposure to specific renal diseases across diverse taxa, none compare renal lesions occurring in wildlife living in different types of human-modified landscapes. We identify lesions characteristic of renal stress, including toxin exposure, in 82 giant toad (Bufo marinus) males living in habitats ranging from suburban to agricultural. In a previous study [McCoy K.A., Bortnick L.J., Campbell C.M., Hamlin H.J., Guillette L.J., Jr., St. Mary C.M. Agriculture Alters Gonadal Form and Function in Bufo marinus. Environ Health Persp; in press.], these individuals were examined for gonadal abnormalities, which were significantly and positively associated with percentage of agriculture at the collection site. Thus, we hypothesized the same association for renal abnormalities. We scored gross anatomical abnormalities and used light microscopy to identify tubular and interstitial lesions that have been associated with toxicant exposure in other organisms, including humans. Renal lesions indicative of tubular disease were observed at one suburban and two agricultural sites, whereas interstitial lesions were most severe at one agricultural site. Although there was no relationship between frequency of renal disease and proportion of agriculture in the collection vicinity, the renal lesions we identify are consistent with toxin exposure and are similar to those found in human drug abusers and patients suffering medication-induced nephropathy. This is the first study to describe renal lesions in a wild amphibian species and investigate the distribution of renal lesions across human altered landscapes. Indentifying the chemicals inducing renal lesions across these landscapes, their toxicological mechanisms, and their implications on wildlife health will help us devise strategies to mitigate the impacts of toxins on humans and animals living in human-modified environments.     

Uni-REPM: validated and improved

Software products are usually developed for either a specific customer (bespoke) or a broader market (market-driven). Due to their characteristic, bespoke and market-driven development face different challenges, especially concerning requirements engineering. Many challenges are caused by an inadequate requirements engineering process, and hence there is a need for process improvement frameworks based on empirical research and industry needs. In a previous article we introduced Uni-REPM, a lightweight requirements engineering process assessment framework based on a review of empirically motivated practices in market-driven and bespoke requirements engineering literature. In this article, we validate this framework in academia as well as industry, in order to prepare Uni-REPM for widespread industry use. We conduct two validations; a static validation based on interviews with seven academic experts and a dynamic validation where Uni-REPM is applied in four industrial organisations. Uni-REPM is refined according to the feedback obtained in the validations. The study shows that Uni-REPM is a quick, simple, and cost-effective solution to assess the maturity level of the requirements engineering process of projects. Moreover, the assessment method using checklists is highly usable and applicable in various international development environments.     

CAR-Miner: An efficient algorithm for mining class-association rules

Building a high accuracy classifier for classification is a problem in real applications. One high accuracy classifier used for this purpose is based on association rules. In the past, some researches showed that classification based on association rules (or class-association rules – CARs) has higher accuracy than that of other rule-based methods such as ILA and C4.5. However, mining CARs consumes more time because it mines a complete rule set. Therefore, improving the execution time for mining CARs is one of the main problems with this method that needs to be solved. In this paper, we propose a new method for mining class-association rule. Firstly, we design a tree structure for the storage frequent itemsets of datasets. Some theorems for pruning nodes and computing information in the tree are developed after that, and then, based on the theorems, we propose an efficient algorithm for mining CARs. Experimental results show that our approach is more efficient than those used previously.     

Stable Isomers of Sila - and Germadodecahedrane. a Semiempirical (Am1) Investigation of the Structure of 4/6 and 4/5/6 Ring Containing E20 (E=SI, GE) Systems

AMI molecular orbital calculations with full geometry optimisation of 4/6, 5/5 and 4/5/6 isomers of E₂₀ (E=Si, Ge) show a clear preference of germanium to be accommodated in four membered rings and to achieve coordination numbers greater than 3 (V A). as a consequence, unlike C₂₀ or Si₂₀, the dodecahedral form of Ge₂₀ was not localised on the potential surface, instead an opened structure derived from an octagermaprismane (IV B) can be predicted. Notable kinetic stabilisation in the (SiR)₂₀ systems is suggested by the HOMO-LUMO differences.     

Time- and temperature-dependence of compressive and tensile behaviors of polypropylene fiber-reinforced cemented paste backfill

The understanding of compressive and tensile behaviors of polypropylene fiber-reinforced cemented paste backfill (FR-CPB) play crucial roles in the successful implementation of reinforcement technique in underground mine backfilling operations. However, very limited studies have been performed to gain insight into the evolution of compressive and tensile behaviors and associated mechanical properties of FR-CPB under various curing temperatures from early to advanced ages. Thus, this study aims to investigate the time (7, 28, and 90 d)- and temperature (20°C, 35°C, and 45°C)-dependence of constitutive behavior and mechanical properties of FR-CPB. The obtained results show that pre- and post-failure behaviors of FR-CPB demonstrate strongly curing temperature-dependence from early to advanced ages. Moreover, the pseudo-hardening behavior is sensitive to curing temperature, especially at early ages. Furthermore, the mechanical properties including elastic modulus, material stiffness, strengths, brittleness, cohesion, and internal friction angle of FR-CPB show increasing trends with curing temperature as curing time elapses. Additionally, a predictive model is developed to capture the strong correlation between compressive and tensile strength of FR-CPB. The findings of this study will contribute to the successful implementation of FR-CPB technology.