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排序方式: 共有1206条查询结果,搜索用时 375 毫秒
1.
Lili Chen Nanami Fujisawa Masato Takanohashi Mazaya Najmina Koichiro Uto Mitsuhiro Ebara 《International journal of molecular sciences》2021,22(5)
This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery. 相似文献
2.
Masahiro Sato Miyu Koriyama Satoshi Watanabe Masato Ohtsuka Takayuki Sakurai Emi Inada Issei Saitoh Shingo Nakamura Kazuchika Miyoshi 《International journal of molecular sciences》2015,16(8):17838-17856
Some reports demonstrated successful genome editing in pigs by one-step zygote microinjection of mRNA of CRISPR/Cas9-related components. Given the relatively long gestation periods and the high cost of housing, the establishment of a single blastocyst-based assay for rapid optimization of the above system is required. As a proof-of-concept, we attempted to disrupt a gene (GGTA1) encoding the α-1,3-galactosyltransferase that synthesizes the α-Gal epitope using parthenogenetically activated porcine oocytes. The lack of α-Gal epitope expression can be monitored by staining with fluorescently labeled isolectin BS-I-B4 (IB4), which binds specifically to the α-Gal epitope. When oocytes were injected with guide RNA specific to GGTA1 together with enhanced green fluorescent protein (EGFP) and human Cas9 mRNAs, 65% (24/37) of the developing blastocysts exhibited green fluorescence, although almost all (96%, 23/24) showed a mosaic fluorescent pattern. Staining with IB4 revealed that the green fluorescent area often had a reduced binding activity to IB4. Of the 16 samples tested, six (five fluorescent and one non-fluorescent blastocysts) had indel mutations, suggesting a correlation between EGFP expression and mutation induction. Furthermore, it is suggested that zygote microinjection of mRNAs might lead to the production of piglets with cells harboring various mutation types. 相似文献
3.
为了使橡胶混炼设备能够适应新材料新工艺的快速发展,在现今不稳定的商业投资环境下,选择一种高度灵活性的传动系统,既能使设备保有先进性,又能很快得到投资回报,可谓为一种不可多得的投资理念,Haqqlunds公司生产的带液压电机传动系统,可使相切型密炼机的产品质量远远好于采用传统的固定速度,速比密炼机的产品质量,也可使啮合型密炼机充分利用所配置的传动功率,还可广泛用于开炼机,双螺杆压片机和压延机,业已证明,其工作可靠,维修便宜。 相似文献
4.
Masato Enomoto 《Metallurgical and Materials Transactions A》1991,22(6):1235-1245
A previously developed computer model was modified to simulate the growth of grain boundary precipitates which grow by the ledge mechanism. The ledges were assumed to be nucleated in the grain boundary region at constant, parabolically decreasing, and random rates and to grow under the control of volume diffusion of solute to or from the riser of ledges. At lower under coolings at which the motion of individual ledges is slow, late-nucleated ledges soon catch up with first-nucleated ones, and precipitates tend to extend along the grain boundary: the overall precipitate shape is essentially that of a grain boundary allotriomorph. At larger undercoolings, first-nucleated ledges move fast to form a protuberance similar to Widmanstätten sideplates, while late-nucleated ones stay near the grain boundary region. The transition of precipitate shape from one to the other occurs in a very narrow range of supersaturation. The results are compared with various characteristics of the growth of proeutectoid ferrite allotriomorphs and sideplates in Fe-C alloys documented in the literature. 相似文献
5.
Keita Ikeue Shingo Ando Tomohiro Mitsuyama Yusuke Ohta Keishi Arayama Akiko Tsutsumi Masato Machida 《Topics in Catalysis》2008,47(3-4):175-180
Lanthanide-based oxysulfides and sulfide, LnTaO3.5S0.5, Ln10OS14 (Ln = La, Pr, Nd, Sm) and La4In5S13, were successively synthesized by sulfurization in a flowing H2S. The sulfurization decreased the band-gap energies from >4 eV to <3eV, because of the formation of occupied S3p orbitals
on the top of valence band. In accordance with the small band gap, the H2 evolution from a 0.01 M Na2S and 0.01 M Na2SO3 solution system was observed under irradiation of light up to >500 nm. The rate of H2 evolution under light irradiation of >500 nm increased in the order of Ni/LaTaO3.5S0.5 < Ru/La10OS14 < Pt/La4In5S13. 相似文献
6.
K. Fujii J. Fujimoto H. Hayashii R. Kajikawa Y. Masatani H. Ozaki A. Sugiyama R. Suzaki S. Suzuki T.Y. Tsukamoto T.F. Tsukamoto S. Uno S. Iwata 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》1985,236(1):55-63
We constructed and tested a prototype gas sampling electromagnetic calorimeter of the Pb-proportional tube sandwich type. The calorimeter uses conductive plastic tubes and cathode pad readout with a tower structure which resulted in reasonable energy and spatial resolutions for electrons in the momentum range 0.5–4.0 GeV/c; /c). This paper describes the test and the performance studied under various conditions. 相似文献
7.
Masato Tanaka 《加拿大化工杂志》1985,63(5):723-727
The local variation of droplet diameter in a stirred tank was measured in the vicinity of the impeller and at another region. The degree of difference in droplet diameter between regions increases with the impeller speed. A correlation equation between the local difference in droplet diameter and the frequencies of coalescence and circulation of the droplet was derived according to the circulation interaction model. The degree of local difference in droplet diameter was found to be controlled strongly by the ratio of coalescence to circulation frequency. 相似文献
8.
An advanced learning system for interactive simulation of patient cases (ISP) is described. The system was designed to meet specific pedagogical needs where student activation and problem orientation were two of the key issues. The system includes features such as video based illness history-taking function using free text input, highly interactive physiological examination procedures, extensive laboratory tests and detailed user feedback. The system was constructed mainly in Authorware Professional, starting more than 10 years ago, and it is now available in refined versions in different languages. Twelve pedagogical and three technical features were initially defined for the project. All of these aims were fulfilled. The ISP system has been successfully used in education, and in international collaboration, including three applicability field tests. The system is also a powerful research tool for studying for instance medical decision-making. 相似文献
9.
Miao Wang Xinluo Zhao Masato Ohkohchi Yoshinori Ando 《Fullerenes, Nanotubes and Carbon Nanostructures》1996,4(5):1027-1039
Carbon nanotubes prepared by de arc discharge of graphite electrodes in He and CH4 gas took markedly different morphology. Thick nanotubes embellished with many carbon nanoparticles were obtained by evaporation under high CH4 gas pressure and high arc current. Thin and long carbon nanotubes were obtained under a CH4 gas pressure of 50Torr and an arc current of 20A for the anode with a diameter of 6mm. 相似文献
10.
Masato Miyauchi Atsuko Miyake Yukio Nakanishi Yasuyuki Sagara 《Drying Technology》1995,13(8):1741-1761
An experimental study has been carried out on the characteristics of binary adsorption isotherms of water and volatile flavor for typical materials used in a box of a tobacco product or cigarettes. Ethyl acetate chosen as a model for water-soluble volatile flavor. Binary adsorption isotherms for the tobacco, papers, filters, and activated carbons were measured with a flow-type multi-component adsorption system under the canstant conditions of temperature a t 303 K and vapor pressure of water a t 2.5 kPain the vapor pressure range of ethyl acetate from 0 to 4.2 kPa. A linear equation was applied to express the binary adsorption isotherms for the tobacco, papers and filters, while a Dubinin-Astakhov equation was applied for the activated carbons. The binary adsorption was characterized into three groups, depending on the selectivity as well as the mechanism of adsorption; i.e.(l) for tobacco and papers, water was adsorbed much greater rather than ethyl acetate, (2) for filters, ethyl acetate was adsorbed on the surface as great as water, (3) for activated carbons, ethyl acetate was adsorbed much greater onto their micropores rather than water. The results showed that ethyl 相似文献