Androgen Receptor Gene Pathway Upregulation and Radiation Resistance in Oligometastatic Prostate Cancer

Stereotactic ablative body radiotherapy (SABR) is currently used as a salvage intervention for men with oligometastatic prostate cancer (PC), and increasingly so since the results of the Stereotactic Ablative Body Radiotherapy for the Comprehensive Treatment of Oligometastatic Cancers (SABR-COMET) trial reported a significant improvement in overall survival with SABR. The addition of androgen deprivation therapy (ADT) to localised prostate radiotherapy improves survival as it sensitises PC to radiotherapy-induced cell death. The importance of the androgen receptor (AR) gene pathway in the development of resistance to radiotherapy is well established. In this review paper, we will examine the data to determine how we can overcome the upregulation of the AR pathway and suggest a strategy for improving outcomes in men with oligometastatic hormone-sensitive PC.     

Presence: a unique characteristic in educational virtual environments

This article investigates the effect of presence on learning outcomes in educational virtual environments (EVEs) in a sample of 60 pupils aged between 11 and 13 years. We study the effect of personal presence, social presence and participant’s involvement on certain learning outcomes. We also investigate if the combination of the participant’s representation model in the virtual environment (VE) with the way it is presented gives a higher sense of presence that contributes to learning outcomes. Our results show that the existence of an avatar as the pupils’ representation enhanced presence and helped them to successfully perform their learning tasks. The pupils had a high sense of presence for both cases of the EVE presentation, projection on a wall and through a head mounted display (HMD). Our socialized virtual environment seems to play an important role in learning outcomes. The pupils had a higher sense of presence and completed their learning tasks more easily and successfully in the case of their egocentric representation model using the HMD.     

Positive Streamer Propagation and Breakdown in Air: the Influence of Humidity

The influence of humidity on streamer propagation at conditions from the threshold for propagation to those for streamer-induced breakdown was investigated in a uniform field in air at atmospheric pressure. Experiments were carried out in a three electrode arrangement consisting of a 12 cm long parallel-plane gap, with an auxiliary needle in the earthed anode. Positive streamers were initiated by applying at the needle electrode a pulse voltage which varied in amplitude. These propagated towards the upper plane electrode which was stressed by a negative dc voltage. Under natural atmospheric conditions, propagation and breakdown probability curves were obtained for several values of absolute humidity in the range between 5 and 22 g/m³. Thus, distributions of the electric field required for streamer propagation and breakdown were obtained and the associated velocity of propagation and time to breakdown were measured. Besides humidity, the amplitude of the voltage used for streamer initiation and the ambient electric field were considered as influencing parameters on streamer properties. Empirical equations are presented expressing the effects of the above parameters on the intrinsic streamer properties. A comparison with previous work in the literature is made and this leads to the conclusion that the influence of humidity on streamer propagation and breakdown can be placed in a sounder quantitative basis.     

Surface profile effect on streamer propagation and breakdown in air

In a uniform field arrangement, under direct voltage, positive streamer propagation and breakdown are investigated along cylindrical insulators with different profiles, inserted perpendicularly between two parallel plane electrodes. The basic properties of streamer propagation and breakdown, namely the electric field required for a stable propagation together with the associated velocity and the breakdown field together with time to breakdown, are measured as influenced by the pulse voltage amplitude used for the streamer initiation and by the insulator profile. It is shown that a strong relation between streamer propagation and breakdown exists, because the insulator profile exerts a similar influence on the breakdown and propagation fields. The effect of a shed on an insulating surface, forming an `obstruction' to streamer progress, is to increase the stability for propagation and breakdown fields, and to reduce the propagation velocity at all applied fields compared with those in the case of a smooth insulator. Along the surface of a smooth insulator, a streamer system propagates with a `surface' and an `air' component; however, a shed on an insulating surface modifies this system, resulting in only one component reaching the cathode     

Picosecond Phase Conjugation in Sodium Vapour

Abstract

Phase conjugation by degenerate four-wave mixing in sodium vapour was demonstrated using 80 ps transform-limited pulses. Values of the phase-conjugated reflectivity were measured as a function of the temperature of the vapour and the delay of the probe beam.     

Streamer propagation along room-temperature-vulcanised silicon-rubber-coated cylindrical insulators

Results concerning streamer propagation along cylindrical insulators coated with room-temperature-vulcanised silicon rubber coatings are presented. Experiments were carried out in a three-electrode arrangement consisting of a 12 cm long parallel-plane gap with an auxiliary needle in the earthed anode. Insulators could be inserted between the plane electrodes adjacent to them and almost in contact with the needle. Positive streamers were initiated by applying at the needle electrode a pulse voltage variable in amplitude and propagated over the insulators towards the upper plane electrode which was stressed by a negative DC voltage. The streamer propagation field at conditions from threshold up to the stable streamer propagation and the associated velocity were measured. The dependence of the streamer velocity on the electric field was investigated with the type of coating as parameter. Both the streamer propagation field and the associated velocity of propagation are higher, when a streamer propagates along the coated insulators, than the reference bare nylon insulator depending on the coating employed. Streamers might be used as an effective probe for studying the surface dielectric behaviour of coated insulators hence also for evaluating the various coatings used to improve the contamination performance of outdoor high-voltage insulators.     

Streamer propagation along insulating surfaces

Results concerning the propagation of streamers along insulating surfaces under uniform electric field are presented. The basic properties of streamers, namely the electric field required for a stable propagation and the propagation velocity, have been measured and compared with propagation in air alone as a reference. The results have shown that in the experimental arrangement used significant space charges due to streamer branching are absent, therefore the properties observed are considered as characteristic of a single streamer. Streamers propagate stably with an intrinsic propagation field and a characteristic velocity that depend on the nature of the insulating material. For electric fields higher than the minimum field required for a stable propagation, a streamer system propagates with a `surface' and an `air' component     

Educational virtual environments: A ten-year review of empirical research (1999–2009)

This study is a ten-year critical review of empirical research on the educational applications of Virtual Reality (VR). Results show that although the majority of the 53 reviewed articles refer to science and mathematics, researchers from social sciences also seem to appreciate the educational value of VR and incorporate their learning goals in Educational Virtual Environments (EVEs). Although VR supports multisensory interaction channels, visual representations predominate. Few are the studies that incorporate intuitive interactivity, indicating a research trend in this direction. Few are the settings that use immersive EVEs reporting positive results on users’ attitudes and learning outcomes, indicating that there is a need for further research on the capabilities of such systems. Features of VR that contribute to learning such as first order experiences, natural semantics, size, transduction, reification, autonomy and presence are exploited according to the educational context and content. Presence seems to play an important role in learning and it is a subject needing further and intensive studies. Constructivism seems to be the theoretical model the majority of the EVEs are based on. The studies present real world, authentic tasks that enable context and content dependent knowledge construction. They also provide multiple representations of reality by representing the natural complexity of the world. Findings show that collaboration and social negotiation are not only limited to the participants of an EVE, but exist between participants and avatars, offering a new dimension to computer assisted learning. Little can yet be concluded regarding the retention of the knowledge acquired in EVEs. Longitudinal studies are necessary, and we believe that the main outcome of this study is the future research perspectives it brings to light.