Human sweat odour conjugates in human milk,colostrum and amniotic fluid

Using ultra performance liquid chromatography–mass spectrometry we identified for the first time glutamine-N-α-conjugates of the fatty acids (E)/(Z)-3-methylhex-2-enoic acid and (R)/(S)-3-hydroxy-3-methylhexanoic acid as well as cysteinylglycine-S-conjugates of (R)/(S)-3-methyl-3-sulphanylhexan-1-ol and (R)/(S)-3-sulphanylhexan-1-ol as constituents of human milk and colostrum. The glutamine-N-α-conjugates were detected also in human amniotic fluids. The mean values of glutamine-N-α-conjugate of (R)/(S)-3-hydroxy-3-methylhexanoic acid were highest in colostrums with a range of <0.1–382 μg/kg, followed by the mature human milk with values from <0.1 to 39.6 μg/kg for defatted milk, and 0.8–7.0 μg/kg in amniotic fluids. The cysteinylglycine-S-conjugate of (R)/(S)-3-methyl-3-sulphanylhexan-1-ol were detected in the range of 2–24 ng/kg in human milk, and 7–101 ng/kg in colostrums. Our data demonstrate that concentrations in human milk vary between individuals, and with lactation period as the mean concentrations of the glutamine conjugates in colostrums were elevated in comparison to mature milk and the concentrations of acid precursors were close to 10 times higher. Further, these precursors were not detected in cow milk.     

A Single Photon Avalanche Diode Implemented in 130-nm CMOS Technology

We report on the first implementation of a single photon avalanche diode (SPAD) in 130 nm complementary metal-oxide-semiconductor (CMOS) technology. The SPAD is fabricated as p+/n-well junction with octagonal shape. A guard ring of p-well around the p+ anode is used to prevent premature discharge. To investigate the dynamics of the new device, both active and passive quenching methods have been used. Single photon detection is achieved by sensing the avalanche using a fast comparator. The SPAD exhibits a maximum photon detection probability of 41% and a typical dark count rate of 100 kHz at room temperature. Thanks to its timing resolution of 144 ps full-width at half-maximum (FWHM), the SPAD has several uses in disparate disciplines, including medical imaging, 3D vision, biophotonics, low-light illumination imaging, etc.     

Toward a 3-D camera based on single photon avalanche diodes

A three-dimensional (3-D) imager is presented, capable of computing the depth map as well as the intensity scale of a given scene. The heart of the system is a two-dimensional array of single photon avalanche diodes fabricated in standard CMOS technology. The diodes exhibit low-noise equivalent-power high-dynamic range, and superior linearity. The 3-D imager achieves submillimetric precision at a depth-of-field of a few meters. This precision was achieved by averaging over 10 000 measurements. The imager operates using a standard laser source pulsed at 50 MHz with 40-mW peak power and requires no mechanical scanning mechanisms or expensive optical equipment.     

Design and characterization of a CMOS 3-D image sensor based on single photon avalanche diodes

The design and characterization of an imaging system is presented for depth information capture of arbitrary three-dimensional (3-D) objects. The core of the system is an array of 32 /spl times/ 32 rangefinding pixels that independently measure the time-of-flight of a ray of light as it is reflected back from the objects in a scene. A single cone of pulsed laser light illuminates the scene, thus no complex mechanical scanning or expensive optical equipment are needed. Millimetric depth accuracies can be reached thanks to the rangefinder's optical detectors that enable picosecond time discrimination. The detectors, based on a single photon avalanche diode operating in Geiger mode, utilize avalanche multiplication to enhance light detection. On-pixel high-speed electrical amplification can therefore be eliminated, thus greatly simplifying the array and potentially reducing its power dissipation. Optical power requirements on the light source can also be significantly relaxed, due to the array's sensitivity to single photon events. A number of standard performance measurements, conducted on the imager, are discussed in the paper. The 3-D imaging system was also tested on real 3-D subjects, including human facial models, demonstrating the suitability of the approach.