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1.
Dr. Omer K. Rasheed Cassandra Buhl Dr. Jay T. Evans Dr. Kendal T. Ryter 《ChemMedChem》2021,16(8):1246-1251
Mincle agonists have been shown to induce inflammatory cytokine production, such as tumor necrosis factor-alpha (TNF) and promote the development of a Th1/Th17 immune response that might be crucial to development of effective vaccination against pathogens such as Mycobacterium tuberculosis. As an expansion of our previous work, a library of 6,6′-amide and sulfonamide α,α-d -trehalose compounds with various substituents on the aromatic ring was synthesized efficiently in good to excellent yields. These compounds were evaluated for their ability to activate the human C-type lectin receptor Mincle by the induction of cytokines from human peripheral blood mononuclear cells. A preliminary structure–activity relationship (SAR) of these novel trehalose diamides and sulfonamides revealed that aryl amide-linked trehalose compounds demonstrated improved activity and relatively high potency cytokine production compared to the Mincle ligand trehalose dibehenate adjuvant (TDB) and the natural ligand trehalose dimycolate (TDM) inducing dose-dependent and human-Mincle-specific stimulation in a HEK reporter cell line. 相似文献
2.
The morphological evolution of hillocks at the unpassivated sidewalls of single-crystal metallic thin film interconnects is investigated via computer simulations using the free-moving boundary value problem. The effect of drift-diffusion anisotropy on the development of surface topographical scenarios is fully explored under the action of electromigration and capillary forces, utilizing numerous combinations of the surface texture, the drift-diffusion anisotropy and the direction of the applied electric field. The simulation studies yield analytical relationships for the velocity of the surface solitary waves and the drift velocity of electromigration-induced internal voids as a function of the applied current densities, which contain intrinsic and structural properties of the single-crystal thin films. The threshold value of the applied current density, above which electromigration-induced internal voids can be formed and may cause the catastrophic failure of interconnects by breaching, also appears explicitly in this relationship. 相似文献
3.
We show how to construct pseudo-random permutations that satisfy a certain cycle restriction, for example that the permutation
be cyclic (consisting of one cycle containing all the elements) or an involution (a self-inverse permutation) with no fixed
points. The construction can be based on any (unrestricted) pseudo-random permutation. The resulting permutations are defined
succinctly and their evaluation at a given point is efficient. Furthermore, they enjoy a fast forward property, i.e. it is possible to iterate them at a very small cost.
Received 10 August 2000 and revised 30 September 2000 Online publication 9 April 2001 相似文献
4.
The Journal of Supercomputing - This research presents the detection and mitigation of distributed denial of service (DDoS) in software defined networks (SDN). The proposed method consists of three... 相似文献
5.
Given an array ofn input numbers, therange-maxima problem is that of preprocessing the data so that queries of the type what is the maximum value in subarray [i..j] can be answered quickly using one processor. We present a randomized preprocessing algorithm that runs inO(log*
n) time with high probability, using an optimal number of processors on a CRCW PRAM; each query can be processed in constant time by one processor. We also present a randomized algorithm for a parallel comparison model. Using an optimal number of processors, the preprocessing algorithm runs inO( (n)) time with high probability; each query can be processed inO ( (n)) time by one processor. (As is standard, (n) is the inverse of Ackermann function.) A constant time query can be achieved by some slowdown in the performance of the preprocessing stage. 相似文献
6.
Gert Roebben Omer Van der Biest Diletta Sciti Alida Bellosi Corneliu Sarbu Tom Lauwagie 《Journal of the American Ceramic Society》2005,88(8):2152-2158
Detailed stiffness and internal friction ( Q −1 ) versus temperature curves were obtained for liquid-phase-sintered silicon carbides using advanced resonant beam analysis up to 1400°C. As-sintered materials display a stable Q −1 -peak near 1100°C, superimposed on an increasing background. The change of stiffness associated with the damping peak is quantitatively related to the amount of matter in pockets of the amorphous intergranular phase in which the refractory SiC matrix grains are embedded. The successful removal of the amorphous pockets by annealing at 1900°C is deduced from the disappearance of the damping peak and confirmed with transmission electron microscopy. 相似文献
7.
Sudip Adhikari Sunil Adhikary Ashraf M.M. Omer Mohamad Rusop Hideo Uchida Tetsuo Soga Masayoshi Umeno 《Diamond and Related Materials》2005,14(11-12):1824
Nitrogenated diamond-like (DLC:N) carbon thin films have been deposited by microwave surface wave plasma chemical vapor deposition on silicon and quartz substrates, using argon gas, camphor dissolved in ethyl alcohol composition and nitrogen as plasma source. The deposited DLC:N films were characterized for their chemical, optical, structural and electrical properties through X-ray photoelectron spectroscopy, UV/VIS/NIR spectroscopy, Raman spectroscopy, atomic force microscope and current–voltage characteristics. Optical band gap decreased (2.7 to 2.4 eV) with increasing Ar gas flow rate. The photovoltaic measurements of DLC:N / p-Si structure show that the open-circuit voltage (Voc) of 168.8 mV and a short-circuit current density (Jsc) of 8.4 μA/cm2 under light illumination (AM 1.5 100 mW/cm2). The energy conversion efficiency and fill factor were found to be 3.4 × 10− 4% and 0.238 respectively. 相似文献
8.
Magnetic Resonance Materials in Physics, Biology and Medicine - The success of parallel Magnetic Resonance Imaging algorithms like SENSitivity Encoding (SENSE) depends on an accurate estimation of... 相似文献
9.
A k-query locally decodable code (LDC) allows to probabilistically decode any bit of an encoded message by probing only k bits of its corrupted encoding. A stronger and desirable property is that of self-correction, allowing to efficiently recover not only bits of the message but also arbitrary bits of its encoding. In contrast to the
initial constructions of LDCs, the recent and most efficient constructions are not known to be self-correctable. The existence
of self-correctable codes of comparable efficiency remains open. 相似文献
10.
Problems about the uncertainty in raw material compositions are a critical issue for the blending problems. It is feared that uncertainty in raw material compositions would often cause percent values of the actual blend to go out of specification limits. In this paper, the aleatory and epistemic uncertainties have been handled simultaneously in a blending optimization problem for brass casting. The aleatory and epistemic uncertainties are modeled by using probability and possibility theories respectively. However, the probabilistic and the possibilistic uncertainties are different from the each other. Therefore to solve the mathematical model, including these uncertainties, a transformation of any type of uncertainty to the other is needed. In this study, probabilistic uncertainties are transformed to the possibilistic uncertainties by considering Rong and Lahdelma’s (2008) and the Dubois, Prade, and Sandri (1993) and Dubois, Foulloy, Mauris, and Prade (2004) transformation approaches. This transformation process converts the former model to a possibilistic model. Then the possibilistic models, obtained from each transformation, are solved by using α cuts approach. The solutions of the two possibilistic models have shown that the model, which uses Dubois’s transformation, prepares blends with lower cost than the other model, which uses Rong and Lahdelma’s transformation. 相似文献