Flowsheet Options for Cobalt Recovery in African Copper–cobalt Hydrometallurgy Circuits

The price of cobalt has increased by some 450% in the past two years, mainly due to increasing demand for lithium–ion batteries. With an official 2017 production of 64 kt, the Democratic Republic of Congo produces more than half of the world’s cobalt. African Copperbelt operations have traditionally focused on copper production; however, it has now become imperative to also consider cobalt recovery from these ores. A plethora of processing routes is possible. Most hydrometallurgical flowsheets recover cobalt from the raffinate of the low-grade copper solvent-extraction circuit. Downstream purification processes include sequential precipitation with a variety of reagents, solvent extraction, and ion exchange. Product choices include hydroxide, carbonate, sulfate, and metal cathode. This study assesses technical and economic advantages and limitations of various approaches to the hydrometallurgical processing of cobalt in an African context.     

The extended quadratic residue code is the only (48,24,12) self-dual doubly-even code

An extremal self-dual doubly-even binary (n,k,d) code has a minimum weight d=4/spl lfloor/n/24/spl rfloor/+4. Of such codes with length divisible by 24, the Golay code is the only (24,12,8) code, the extended quadratic residue code is the only known (48,24,12) code, and there is no known (72,36,16) code. One may partition the search for a (48,24,12) self-dual doubly-even code into three cases. A previous search assuming one of the cases found only the extended quadratic residue code. We examine the remaining two cases. Separate searches assuming each of the remaining cases found no codes and thus the extended quadratic residue code is the only doubly-even self-dual (48,24,12) code.     

Non-equilibrium particle motion in the vicinity of a single blade

The motion of sand particles close to a single moving blade was investigated using Positron Emission Particle Tracking (PEPT) during the period in which the free bed surface profile was evolving to an equilibrium shape. The area affected by the blade was divided into active and inactive regions and these were analysed separately. The characteristic heart-shape of the active region in the plan view was determined. An approximately 10-particle-diameter wide velocity transition zone is found between the two regions. While the tracer particle is in the inactive region moving away from the blade, the time dependence of the axial displacement is well described by a logarithmic relationship. The probability of particle movement towards the centre of the blade was quantified using a “central tendency” index. The calculated central tendency shows maxima at each side of the blade. The separation of the two maxima, which indicates the width of the active region, increases with fill level but is independent of rotational speed.     

Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines

BACKGROUND: Topotecan (TPT) is a topoisomerase I poison that exhibits antineoplastic activity. Analysis of the cytotoxic effects of combinations of TPT and other anticancer agents has been limited. PURPOSE: We assessed the cytotoxic effects produced by combinations of TPT and other antineoplastic agents in experiments involving multiple human cancer cell lines of diverse histologic origins. METHODS: The cytotoxic effects of various antimetabolites (fluorouracil, methotrexate, or cytarabine), antimicrotubule agents (vincristine or paclitaxel [Taxol]), DNA alkylating agents (melphalan, bis[chloroethyl]nitrosourea [BCNU], or 4-hydroperoxycyclophosphamide [4HC]), and a DNA-platinating agent (cisplatin), alone and in combination with TPT, were measured in clonogenic (i.e., colony-forming) assays. HCT8 ileocecal adenocarcinoma, A549 non-small-cell lung carcinoma, NCI-H82ras(H) lung cancer, T98G glioblastoma, and MCF-7 breast cancer cell lines were used in these assays. The data were analyzed by the median effect method, primarily under the assumption that drug mechanisms of action were mutually nonexclusive (i.e., completely independent of one another). For each level of cytotoxicity (ranging from 5% to 95%), a drug combination index (CI) was calculated. A CI less than 1 indicated synergy (i.e., the effect of the combination was greater than that expected from the additive effects of the component agents), a CI equal to 1 indicated additivity, and a CI greater than 1 indicated antagonism (the effect of the combination was less than that expected from the additive effects of the component agents). RESULTS: When the mechanisms of drug action were assumed to be mutually nonexclusive, virtually all CIs for combinations of TPT and either antimetabolites or antimicrotubule agents revealed cytotoxic effects that were less than additive. The CIs calculated at low-to-intermediate levels of cytotoxicity for combinations of TPT and the DNA alkylating agents melphalan, BCNU, and 4HC also showed drug effects that were less than additive; in most cases, however, nearly additive or even synergistic effects were observed with these same drug combinations at high levels of cytotoxicity (i.e., at > or = 90% inhibition of colony formation). Results obtained with combinations of TPT and cisplatin varied according to the cell line examined. With A549 cells, less than additive effects were seen at low-to-intermediate levels of cytotoxicity, and more than additive effects were seen at high levels of cytotoxicity. With NCI-H82ras(H) cells, synergy was observed over most of the cytotoxicity range. CONCLUSIONS AND IMPLICATIONS: TPT cytotoxicity appears to be enhanced more by combination with certain DNA-damaging agents than by combination with antimetabolites or antimicrotubule agents. Interactions between TPT and other drugs can vary depending on the cell type examined. Further investigation is required to determine the basis of the observed effects and to determine whether these in vitro findings are predictive of results obtained in vivo.     

Men, medicine and machines

PURPOSE: To examine the management and possible causes of primary valve malfunction of the Krupin eye valve with disk. METHODS: The authors reviewed the results of 113 patients undergoing implantation of the Krupin eye valve with disk and identified eight patients with primary valve malfunction requiring surgical revision. RESULTS: Valve revision involved manipulation (n = 1 case), explantation of the malfunctioning valve and implantation of a new valve (n = 2), and amputation of the valve (n = 5). Six of eight patients had final intraocular pressures of < 21 mmHg on one or no medications at a mean interval of 15.9 months (range 5-36) after surgical revision. Transient postoperative hypotony was noted in three patients and chronic hypotony with loss of light perception in one patient. One explanted valve was examined and found to have partially fused leaflets. CONCLUSIONS: Surgical revision in cases of primary valve malfunction of the Krupin eye valve with disk may be accomplished relatively safely with an acceptable level of postoperative complications. The etiology of primary valve malfunction may be related to the sterilization process and prolonged storage before implantation.     

Diffusion bonding of ferritic oxide dispersion strengthened alloys to austenitic superalloys

The superior high temperature mechanical strength and oxidation resistance of ferritic oxide dispersion strengthened (ODS) tubular alloys are compromised by the difficulties encountered in joining. Conventional fusion welding techniques generate a weld fusion zone which is devoid of the mechanical strength exhibited by the base material. Therefore, more sophisticated solid state joining techniques, such as diffusion bonding, must be employed when joining ODS materials. This paper describes a series of solid state diffusion bonding experiments carried out between two tubular ferritic ODS alloys and two high temperature austenitic alloys. Careful control of bonding conditions produced pressure retaining joints between one of the tubular ODS alloys and both austenitic alloys. The successful joint design was incorporated into the manufacture of a tubular creep component, which enabled a series of internally pressurized creep tests to be carried out. The microstructure developed at the bond interface of each of the four separate material couples is described and the high temperature performance of the pressure retaining joints is discussed.     

Role of Ponded Turbidity Currents in Reservoir Trap Efficiency

The capacity to store water in a reservoir declines as it traps sediment. A river entering a reservoir forms a prograding delta. Coarse sediment (e.g., sand) deposits in the fluvial topset and avalanching foreset of the delta, and is typically trapped with an efficiency near 100%. The trap efficiency of fine sediment (e.g., mud), on the other hand, may be below 100%, because some of this sediment may pass out of the reservoir without settling out. Here, a model of trap efficiency of mud is developed in terms of the mechanics of a turbidity current that plunges on the foreset. The dam causes a sustained turbidity current to reflect and form a muddy pond bounded upstream by a hydraulic jump. If the interface of this muddy pond rises above any vent or overflow point at the dam, the trap efficiency of mud drops below 100%. A model of the coevolution of topset, foreset, and bottomset in a reservoir that captures the dynamics of the internal muddy pond is presented. Numerical implementation, comparison against an experiment, and application to a field-scale case provide the basis for a physical understanding of the processes that determine reservoir trap efficiency.     

An extended panel of hamster-human hybrids for chromosome 2q

A hamster-human hybrid containing only the q arm of chromosome 2 has been used to construct a panel of hybrids bearing reduced regions of chromosome 2 using the technique of irradiation fusion gene transfer. The human chromosome 2 carried the Ecogpt gene and all hybrids were selected using this marker. The integrated Ecogpt gene was localized to the region 2q33-34, resulting in the selective retention of this region in the hybrids. These data were combined with another previously constructed panel of hybrids containing regions of 2q, which were enriched for the region 2q36-37. The combined hybrid panel is useful for the mapping of new markers to defined regions of chromosome 2 and for the cloning of genes located on 2q by a positional strategy.