Transgenic animals in toxicology

Recent advances have been made in the characterization of a number of transgenic animal models. These animal models have provided a powerful toxicological tool for studying in vivo chemical effects and have increased our understanding of the role of specific genetic alterations as predisposing factors for chemical carcinogenesis. The goal of this symposium was to introduce the development of transgenic animals and the utilization of transgenics in toxicology research focusing on understanding tissue-specific mutation, chemical effects, and cancer. The production of transgenic animals, including gene insertions and gene knockouts, and the utilization of transgenic technology for studying multistage carcinogenesis and tumor suppressor genes are described. Data on the application and implications of transgenics as a genetic endpoint are also discussed. The use of transgenic animals in toxicology should improve our understanding of the role of specific genetic alterations in the carcinogenic process and lead to improved estimations of human health risks.     

The Perception of Graph Properties in Graph Layouts

When looking at drawings of graphs, questions about graph density, community structures, local clustering and other graph properties may be of critical importance for analysis. While graph layout algorithms have focused on minimizing edge crossing, symmetry, and other such layout properties, there is not much known about how these algorithms relate to a user's ability to perceive graph properties for a given graph layout. In this study, we apply previously established methodologies for perceptual analysis to identify which graph drawing layout will help the user best perceive a particular graph property. We conduct a large scale (n = 588) crowdsourced experiment to investigate whether the perception of two graph properties (graph density and average local clustering coefficient) can be modeled using Weber's law. We study three graph layout algorithms from three representative classes (Force Directed ‐ FD, Circular, and Multi‐Dimensional Scaling ‐ MDS), and the results of this experiment establish the precision of judgment for these graph layouts and properties. Our findings demonstrate that the perception of graph density can be modeled with Weber's law. Furthermore, the perception of the average clustering coefficient can be modeled as an inverse of Weber's law, and the MDS layout showed a significantly different precision of judgment than the FD layout.     

A high duty-cycle,multi-channel,power amplifier for high-resolution radiofrequency encoded magnetic resonance imaging

Magnetic Resonance Materials in Physics, Biology and Medicine - A radiofrequency (RF) power amplifier is an essential component of any magnetic resonance imaging (MRI) system. Unfortunately, no...     

Defining multimedia

Multimedia is variously and often ambiguously defined. While most people might accept a mix of voice, text and graphics, they might resist calling a live lecture on a titled work of art a multimedia presentation. On the other hand, many definitions focus entirely on technology: multimedia seems to be defined by the hardware required rather than by the user's experience. For example, despite the statement that any computer application that employs a video disk, images from a CD-ROM, uses high-quality sound, or uses high-quality video images on a screen may be termed a multimedia application, the author doubts that anyone would use the term multimedia for a computer application that merely plays a piece of music. She suggests a model of media objects that does not refer to technology or interactivity, but rather concentrates on the nature of the text. This model provides a useful basis for defining multimedia communication securely and unambiguously     

Electrochemical deposition of cupric ions for the determination of mass transfer rates to a stepped rotating cylinder electrode

The stepped rotating cylinder electrode (SRCE) geometry has been developed as a simple aid to the practical study of the flow-enhanced corrosion and applied electrochemistry problems commonly observed under conditions of disturbed, turbulent flow. The electrodeposition of cupric ions from an acid sulphate plating bath has been used to characterise differential rates of mass transfer to the SRCE. The variation in thickness of electrodeposited copper films has allowed the mapping of local rates of mass transfer over the active surface of this geometry. Both optical and scanning electron microscopy were used for the examination of metallographic sections to provide a high resolution evaluation of the distribution of mass transfer coefficient. Results are also discussed using the convective-diffusion model in combination with the existing direct numerical flow simulation (DNS) data for this geometry.