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1.
Tommaso Mansi Xavier Pennec Maxime Sermesant Hervé Delingette Nicholas Ayache 《International Journal of Computer Vision》2011,92(1):92-111
Tracking soft tissues in medical images using non-linear image registration algorithms requires methods that are fast and
provide spatial transformations consistent with the biological characteristics of the tissues. LogDemons algorithm is a fast
non-linear registration method that computes diffeomorphic transformations parameterised by stationary velocity fields. Although
computationally efficient, its use for tissue tracking has been limited because of its ad-hoc Gaussian regularisation, which hampers the implementation of more biologically motivated regularisations. In this work, we
improve the logDemons by integrating elasticity and incompressibility for soft-tissue tracking. To that end, a mathematical
justification of demons Gaussian regularisation is proposed. Building on this result, we replace the Gaussian smoothing by
an efficient elastic-like regulariser based on isotropic differential quadratic forms of vector fields. The registration energy
functional is finally minimised under the divergence-free constraint to get incompressible deformations. As the elastic regulariser
and the constraint are linear, the method remains computationally tractable and easy to implement. Tests on synthetic incompressible
deformations showed that our approach outperforms the original logDemons in terms of elastic incompressible deformation recovery
without reducing the image matching accuracy. As an application, we applied the proposed algorithm to estimate 3D myocardium
strain on clinical cine MRI of two adult patients. Results showed that incompressibility constraint improves the cardiac motion
recovery when compared to the ground truth provided by 3D tagged MRI. 相似文献
2.
Magat Julie Ozenne Valéry Cedilnik Nicolas Naulin Jérôme Haliot Kylian Sermesant Maxime Gilbert Stephen H. Trew Mark Haissaguerre Michel Quesson Bruno Bernus Olivier 《Magma (New York, N.Y.)》2021,34(5):741-755
Magnetic Resonance Materials in Physics, Biology and Medicine - The aim of the study is to compare structure tensor imaging (STI) with diffusion tensor imaging (DTI) of the sheep heart... 相似文献
3.
Delingette H Billet F Wong KC Sermesant M Rhode K Ginks M Rinaldi CA Razavi R Ayache N 《IEEE transactions on bio-medical engineering》2012,59(1):20-24
Personalization is a key aspect of biophysical models in order to impact clinical practice. In this paper, we propose a personalization method of electromechanical models of the heart from cine-MR images based on the adjoint method. After estimation of electrophysiological parameters, the cardiac motion is estimated based on a proactive electromechanical model. Then cardiac contractilities on two or three regions are estimated by minimizing the discrepancy between measured and simulation motion. Evaluation of the method on three patients with infarcted or dilated myocardium is provided. 相似文献
4.
Moreau-Villéger V Delingette H Sermesant M Ashikaga H McVeigh E Ayache N 《IEEE transactions on bio-medical engineering》2006,53(8):1457-1466
In this paper, we address the problem of estimating the parameters of an electrophysiological model of the heart from a set of electrical recordings. The chosen model is the reaction-diffusion model on the transmembrane potential proposed by Aliev and Panfilov. For this model of the transmembrane, we estimate a local apparent two-dimensional conductivity from a measured depolarization time distribution. First, we perform an initial adjustment including the choice of initial conditions and of a set of global parameters. We then propose a local estimation by minimizing the quadratic error between the depolarization time computed by the model and the measures. As a first step we address the problem on the epicardial surface in the case of an isotropic version of the Aliev and Panfilov model. The minimization is performed using Brent method without computing the derivative of the error. The feasibility of the approach is demonstrated on synthetic electrophysiological measurements. A proof of concept is obtained on real electrophysiological measures of normal and infarcted canine hearts. 相似文献
5.
Chinchapatnam P Rhode KS Ginks M Rinaldi CA Lambiase P Razavi R Arridge S Sermesant M 《IEEE transactions on medical imaging》2008,27(11):1631-1642
6.
Clatz O Sermesant M Bondiau PY Delingette H Warfield SK Malandain G Ayache N 《IEEE transactions on medical imaging》2005,24(10):1334-1346
We propose a new model to simulate the three-dimensional (3-D) growth of glioblastomas multiforma (GBMs), the most aggressive glial tumors. The GBM speed of growth depends on the invaded tissue: faster in white than in gray matter, it is stopped by the dura or the ventricles. These different structures are introduced into the model using an atlas matching technique. The atlas includes both the segmentations of anatomical structures and diffusion information in white matter fibers. We use the finite element method (FEM) to simulate the invasion of the GBM in the brain parenchyma and its mechanical interaction with the invaded structures (mass effect). Depending on the considered tissue, the former effect is modeled with a reaction-diffusion or a Gompertz equation, while the latter is based on a linear elastic brain constitutive equation. In addition, we propose a new coupling equation taking into account the mechanical influence of the tumor cells on the invaded tissues. The tumor growth simulation is assessed by comparing the in-silico GBM growth with the real growth observed on two magnetic resonance images (MRIs) of a patient acquired with 6 mo difference. Results show the feasibility of this new conceptual approach and justifies its further evaluation. 相似文献
7.
Rhode KS Sermesant M Brogan D Hegde S Hipwell J Lambiase P Rosenthal E Bucknall C Qureshi SA Gill JS Razavi R Hill DL 《IEEE transactions on medical imaging》2005,24(11):1428-1440
The hybrid magnetic resonance (MR)/X-ray suite (XMR) is a recently introduced imaging solution that provides new possibilities for guidance of cardiovascular catheterization procedures. We have previously described and validated a technique based on optical tracking to register MR and X-ray images obtained from the sliding table XMR configuration. The aim of our recent work was to extend our technique by providing an improved calibration stage, real-time guidance during cardiovascular catheterization procedures, and further off-line analysis for mapping cardiac electrical data to patient anatomy. Specially designed optical trackers and a dedicated calibration object have resulted in a single calibration step that can be efficiently checked and updated before each procedure. An X-ray distortion model has been implemented that allows for distortion correction for arbitrary c-arm orientations. During procedures, the guidance system provides a real-time combined MR/X-ray image display consisting of live X-ray images with registered recently acquired MR derived anatomy. It is also possible to reconstruct the location of catheters seen during X-ray imaging in the MR derived patient anatomy. We have applied our registration technique to 13 cardiovascular catheterization procedures. Our system has been used for the real-time guidance of ten radiofrequency ablations and one aortic stent implantation. We demonstrate the real-time guidance using two exemplar cases. In a further two cases we show how off-line analysis of registered image data, acquired during electrophysiology study procedures, has been used to map cardiac electrical measurements to patient anatomy for two different types of mapping catheters. The cardiologists that have used the guidance system suggest that real-time XMR guidance could have substantial value in difficult interventional and electrophysiological procedures, potentially reducing procedure time and delivered radiation dose. Also, the ability to map measured electrical data to patient specific anatomy provides improved visualization and a path to investigation of cardiac electromechanical models. 相似文献
8.
Pop M Sermesant M Mansi T Crystal E Ghate S Peyrat JM Lashevsky I Qiang B McVeigh E Ayache N Wright GA 《IEEE transactions on bio-medical engineering》2011,58(12):3483-3486
The aim of this paper was to compare several in-vivo electrophysiological (EP) characteristics measured in a swine model of chronic infarct, with those predicted by simple 3-D MRI-based computer models built from ex-vivo scans (voxel size <1 mm(3)). Specifically, we recorded electroanatomical voltage maps (EAVM) in six animals, and ECG waves during induction of arrhythmia in two of these cases. The infarct heterogeneities (dense scar and border zone) as well as fiber directions were estimated using diffusion weighted DW-MRI. We found a good correspondence (r = 0.9) between scar areas delineated on the EAVM and MRI maps. For theoretical predictions, we used a simple two-variable macroscopic model and computed the propagation of action potential after application of a train of stimuli, with location and timing replicating the stimulation protocol used in the in-vivo EP study. Simulation results are exemplified for two hearts: one with noninducible ventricular tachycardia (VT), and another with a macroreentrant VT (for the latter, the average predicted VT cycle length was 273 ms, compared to a recorded VT of 250 ms). 相似文献
9.
Mansi T Voigt I Leonardi B Pennec X Durrleman S Sermesant M Delingette H Taylor AM Boudjemline Y Pongiglione G Ayache N 《IEEE transactions on medical imaging》2011,30(9):1605-1616
Cardiac remodelling plays a crucial role in heart diseases. Analyzing how the heart grows and remodels over time can provide precious insights into pathological mechanisms, eventually resulting in quantitative metrics for disease evaluation and therapy planning. This study aims to quantify the regional impacts of valve regurgitation and heart growth upon the end-diastolic right ventricle (RV) in patients with tetralogy of Fallot, a severe congenital heart defect. The ultimate goal is to determine, among clinical variables, predictors for the RV shape from which a statistical model that predicts RV remodelling is built. Our approach relies on a forward model based on currents and a diffeomorphic surface registration algorithm to estimate an unbiased template. Local effects of RV regurgitation upon the RV shape were assessed with Principal Component Analysis (PCA) and cross-sectional multivariate design. A generative 3-D model of RV growth was then estimated using partial least squares (PLS) and canonical correlation analysis (CCA). Applied on a retrospective population of 49 patients, cross-effects between growth and pathology could be identified. Qualitatively, the statistical findings were found realistic by cardiologists. 10-fold cross-validation demonstrated a promising generalization and stability of the growth model. Compared to PCA regression, PLS was more compact, more precise and provided better predictions. 相似文献
10.
E. PernodM. Sermesant E. KonukogluJ. Relan H. DelingetteN. Ayache 《Computers & Graphics》2011,35(2):431-440
Virtual reality-based therapy simulation meets a growing interest from the medical community due to its potential impact for the training of medical residents and the planning of therapies. However, computer models of the human anatomy are often very computationally demanding, thus incompatible with the constraints of such interactive simulations.In this paper, we propose a fast model of the cardiac electrophysiology based on an eikonal formulation implemented with an anisotropic fast marching method. We demonstrate the use of this model in the context of a simulator of radio-frequency ablation of cardiac arrhythmia from patient-specific medical imaging data. Indeed, this therapy can be very effective for patients but still suffers from a rather low success rate. Being able to test different ablation strategies on a patient-specific model can have a great clinical impact.In our setting, thanks to a haptic 3D user interface, the user can interactively measure the local extracellular potential, pace locally the myocardium or simulate the burning of cardiac tissue as done in radio-frequency ablation interventions. 相似文献