Human and guinea pig Hageman factors have been subjected to the action of pseudomonal elastase and serratial E15 proteinase. The pseudomonal elastase cleaved 22-24% of the human molecule at Arg353-Val354, and the remainder at Gly357-Leu358 resulting in the generation of about 20% of potential activity as activated Hageman factor, compared with trypsin activation, while it hydrolyzed Arg340-Ile341 bond in guinea pig molecule and generated about 75% of activity as activated Hageman factor. The serratial proteinase did not hydrolyze the essential cleavage site (Arg353-Val354) of the human zymogen but Gly356-Gly357 (30%) and Gly357-Leu358 (70%) bonds. Both products showed no activity. The guinea pig zymogen, in contrast, was cleaved mostly at Arg340-Ile341 (70%) and less abundantly at Gly344-Leu345 (30%), generating about 85% of the whole potential activity as activated Hageman factor. From the high correspondence between the proportions of activation and of hydrolysis at the essential cleavage site in activation, it was concluded that hydrolysis of the bonds different from the essential bond did not cause activation, even when the spatial separation was only 3 or 4 residues. Considering the amino acid differences between human and guinea pig Hageman factors, -Met351-Thr-Arg-Val-Val-Gly-Gly-Leu-Val-Ala360- and -Leu338-Ser-Arg-Ile-Val-Gly-Gly-Leu-Val-Ala347-, respectively, it was realized that even the minor amino acid substitutions caused the cleavage site shift which resulted in significant differences in activation efficiency of the proteinase zymogens. 相似文献
The Earth Simulator (ES), developed under the Japanese government’s initiative “Earth Simulator project”, is a highly parallel vector supercomputer system. In this paper, an overview of ES, its architectural features, hardware technology and the result of performance evaluation are described.
In May 2002, the ES was acknowledged to be the most powerful computer in the world: 35.86 teraflop/s for the LINPACK HPC benchmark and 26.58 teraflop/s for an atmospheric general circulation code (AFES). Such a remarkable performance may be attributed to the following three architectural features; vector processor, shared-memory and high-bandwidth non-blocking interconnection crossbar network.
The ES consists of 640 processor nodes (PN) and an interconnection network (IN), which are housed in 320 PN cabinets and 65 IN cabinets. The ES is installed in a specially designed building, 65 m long, 50 m wide and 17 m high. In order to accomplish this advanced system, many kinds of hardware technologies have been developed, such as a high-density and high-frequency LSI, a high-frequency signal transmission, a high-density packaging, and a high-efficiency cooling and power supply system with low noise so as to reduce whole volume of the ES and total power consumption.
For highly parallel processing, a special synchronization means connecting all nodes, Global Barrier Counter (GBC), has been introduced. 相似文献
The effect of nonuniform magnetic field on the linear and nonlinear wave propagation phenomena in two-phase pipe flow of magnetic fluid is investigated theoretically to realize the effective energy conversion system using boiling two-phase flow of magnetic fluid. Firstly, the governing equations of two-phase flow based on the unsteady thermal nonequilibrium two-fluid model are presented and the linear void wave propagation phenomena in boiling two-phase flow are numerically analyzed by using the finite volume method. Next, the nonlinear pressure wave propagation in gas-liquid two-phase flow is numerically analyzed by using the finite different method. According to these theoretical studies on the wave propagation phenomena in two-phase flow of magnetic fluid, it seems to be a reasonable proposal that the precise control of the wave propagation in two-phase flow is possible by effective use of the magnetic force. 相似文献
Cobalt-, praseodymium-added zinc oxide varistor was prepared through a wet chemical method followed by sintering with or without
calcination. Changes in grain size, compact density, additives distribution, and voltagecurrent/ capacitance-voltage relations
were investigated for the characterization of the samples sintered at temperatures from 1473 to 1573 K without calcination
or with calcination at 773 K for 2 h. The electrical properties were compared with nhose of samples prepared by two types
of ball mill methods. The wet chemical method provided almost the same additives-distribution profile and less impurities
in comparison with the ball grinding method carried out for 10–100 h. The donor concentration and the potential-barrier height
for the samples were evaluated by Double Schottky Barrier Model. Addition of small amount of both cobalt and praseodymium
in preparation by the wet chemical method was effective for a better nonlinearity relation between voltage and current, which
has potential for a smaller sized varistor. 相似文献
Mechanisms for plastic deformation in the newly developed Ti-24 at. pct (Ta + Nb + V)-(Zr,Hf)-O alloys (Gum Metal) were investigated
in relation to their unique properties. Transmission electron microscopy revealed that the microstructure after deformation
was characterized by highly distorted crystal images, which are accompanied by numerous “giant faults.” Such plastic behavior
implies that a large amount of elastic stain energy was stored discretely and hierarchically during cold working. Calculated
elastic constants of the Ti-X (Nb,Ta,Mo,V) binary systems predicted that Young’s modulus in 〈001〉 and shear moduli along some
directions including slip systems in a bcc crystal were extraordinary small. The low modulus not only well explains the highly
distorted microstructure observed in the cold-worked specimens, but also signifies that ideal shear strength of the developed
alloys is a very small value, which is close to the practical strength required for plastic deformation in the alloy. This
implies that the giant faults observed in the deformed specimen were formed without the aid of dislocation glide. 相似文献
The recent increase in the demand for power in urban areas has caused changes in the way power is supplied. Underground distribution systems have been introduced for convenience in urban areas and to prevent injuries in case of a crisis. As a result, many new types of power cables are being used. One type, XPLE cables (also called CV cables) have been rapidly taking the place of conventional cables such as OF or SL cables since the 1960s because of their relatively easy installation and maintainability. However, distribution cables used under severe environmental conditions deteriorate rapidly (due mainly to water treeing), and some cables experience insulation breakdown. Therefore, many diagnostic methods have been developed, though they have not been very effective. By combining methods, a high reliability can be achieved in comparison to the use of a single method. However, processing the data is difficult for on-site personnel, so many experts are required. But there is a lack of qualified experts, hence we have turned to the development of expert systems. 相似文献
Skeletal form of KnbO3 crystals growing in Li2B4O7 solvent was in-situ observed at 900℃ and it was found that shallow depression started to develop on the surface of KnbO3 crystals when the crystal size exceeded several micron,typically 7 micron.Based on the quantitative criterion derived by Chernov,the estimated critical size of KNbO3 crystals was 1 micron,which was consistent with the experimental measurement.The kinetic coefficients,Kcorner and Kcr,in the criterion were experimentally obtained in the diffusive-convective and diffusive-advective flow states respectively. 相似文献
Advanced glycosylation end products (AGEs) accumulate on long-lived extracellular matrix proteins and have been implicated in the micro- and macrovascular complications of diabetes mellitus. Within the arterial wall, AGE-modified proteins increase vascular permeability, inactivate nitric oxide activity, and induce the release of growth-promoting cytokines. Recently developed anti-AGE antibodies were used in an immunohistochemical analysis of coronary arteries obtained from type II diabetic and nondiabetic patients. High levels of AGE reactivity were observed within the atherosclerotic plaque present in vessels from selected patients with diabetes. Considered together with the pathological effects of AGEs on vascular wall homeostasis, these data support the role of advanced glycosylation in the rapidly progressive atherosclerosis associated with diabetes mellitus. 相似文献